What is sotalol? Sotalol is a beta-blocker that affects the heart and circulation within the atrium and ventricles (the upper and lower chambers of the heart that allow blood to flow into and out of the heart). Sotalol is used to help keep the heart beating normally in people with certain heart rhythm disorders, such as atrial fibrillation, atrial flutter, ventricular tachycardia, and ventricular fibrillation. Sotalol may also be used for purposes not listed in this medication guide. Warnings You should not use sotalol if you have asthma, low potassium, or a serious heart condition such as severe heart failure, long QT syndrome, slow heartbeats that have caused you to faint, "sick sinus syndrome" or "AV block" (unless you have a pacemaker). You will receive your first few doses of sotalol in a hospital setting where your heart can be monitored in case the medicine causes serious side effects. Before taking this medicine You should not use sotalol if you are allergic to it, or if you have: a serious heart condition such as "sick sinus syndrome" or "AV block" (unless you have a pacemaker); long QT syndrome (in you or a family member); severe heart failure; slow heartbeats that have caused you to faint; asthma or other breathing disorder; very low levels of potassium in your blood; or (if you take sotalol for atrial fibrillation or atrial flutter) severe kidney disease; Do not give sotalol to a child without medical advice. Tell your doctor if you have ever had: kidney disease (or if you are on dialysis); an electrolyte imbalance (such as low levels of potassium or magnesium in your blood); congestive heart failure; coronary artery disease (hardened arteries); breathing problems such as bronchitis or emphysema; a thyroid disorder; diabetes (using sotalol can make it harder for you to tell when you have low blood sugar); a severe allergic reaction. Tell your doctor if you are pregnant. You should not breastfeed while using sotalol. How should I take sotalol? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Sotalol oral is taken by mouth. Sotalol injection is given as an infusion into a vein. A healthcare provider will give you this injection if you are unable to take the medicine by mouth. You will receive your first few doses of sotalol in a hospital setting where your heart can be monitored in case the medicine causes serious side effects. If you already take heart rhythm medication, you may need to stop taking it when you start using sotalol. Carefully follow your doctor's instructions. Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon). Sotalol doses are based on age and body surface area (height and weight) in children. Your child's dose needs may change if the child gains or loses weight, or is still growing. Call your doctor if you are sick with vomiting or diarrhea, or if you have increased thirst, decreased appetite, or are sweating more than usual. You can easily become dehydrated while taking sotalol. This can lead to very low blood pressure, a serious electrolyte imbalance, or kidney failure. You will need frequent medical tests. Your heart function may need to be checked using an electrocardiograph or ECG (sometimes called an EKG). You may also need heart function tests for 1 to 2 weeks after your last dose. Keep using this medicine as directed, even if you feel well. You may need to take sotalol for the rest of your life. Do not skip doses or stop using sotalol without your doctor's advice. Stopping suddenly may make your condition worse. Follow your doctor's instructions about tapering your dose. If you need surgery, tell your surgeon you currently use this medicine. Store at room temperature away from moisture and heat. Do not allow liquid medicine to freeze. Your pharmacist may prepare an oral suspension (liquid) form of sotalol. Keep the suspension at room temperature and throw away suspension any left over after 3 months of use.   What happens if I miss a dose? Skip the missed dose and use your next dose at the regular time. Do not use two doses at one time. Try not to miss any doses. Get your prescription refilled before you run out of medicine completely. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of sotalol can be fatal. What should I avoid while taking sotalol? Avoid taking an antacid within 2 hours before or 2 hours after you take sotalol. Some antacids can make it harder for your body to absorb sotalol. Sotalol side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: chest pain; fast or pounding heartbeats, fluttering in your chest; sudden dizziness (like you might pass out); slow heartbeats (especially if you feel light-headed); swelling, rapid weight gain; or feeling short of breath. Common side effects may include: slow heartbeats; trouble breathing; dizziness; or feeling weak or tired. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect sotalol? Tell your doctor about all your other medicines, especially: other heart medications; blood pressure medication; or insulin or oral diabetes medicine. This list is not complete. Other drugs may affect sotalol, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is spironolactone? Spironolactone is a potassium-sparing diuretic (water pill) that prevents your body from absorbing too much salt and keeps your potassium levels from getting too low. Spironolactone is used to treat heart failure, high blood pressure (hypertension), or hypokalemia (low potassium levels in the blood). Spironolactone also treats fluid retention (edema) in people with congestive heart failure, cirrhosis of the liver, or a kidney disorder called nephrotic syndrome. Spironolactone is also used to diagnose or treat a condition in which you have too much aldosterone in your body. Aldosterone is a hormone produced by your adrenal glands to help regulate the salt and water balance in your body. Warnings You should use spironolactone with caution if you have kidney problems, high levels of potassium in your blood, Addison's disease, if you are unable to urinate, or if you are also taking eplerenone. Spironolactone has caused tumors in animals but it is not known whether this could occur in people. Do not use this medicine for any condition that has not been checked by your doctor. Before taking this medicine You should not use spironolactone if you are allergic to it, or if you have: Addison's disease (an adrenal gland disorder); high levels of potassium in your blood (hyperkalemia); if you are unable to urinate; or if you are also taking eplerenone. To make sure spironolactone is safe for you, tell your doctor if you have: an electrolyte imbalance (such as low levels of calcium, magnesium, or sodium in your blood); kidney disease; liver disease; or heart disease. Tell your doctor if you are pregnant or plan to become pregnant. Having congestive heart failure, cirrhosis, or uncontrolled high blood pressure during pregnancy may lead to medical problems in the mother or the baby. Your doctor should decide whether you take spironolactone if you are pregnant. It may not be safe to breastfeed while using spironolactone. Ask your doctor about any risk. How should I take spironolactone? Take spironolactone exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Do not share this medicine with another person, even if they have the same symptoms you have. You may take spironolactone with or without food, but take it the same way each time. You will need frequent medical tests. This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using spironolactone. If you need surgery, tell your surgeon you currently use this medicine. You may need to stop for a short time. If you are being treated for high blood pressure, keep using this medication even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life. Store at room temperature away from heat, light, and moisture. Dosing information Usual Adult Dose for Edema: 25 to 200 mg orally per day in single or divided doses Duration of therapy: When given as the sole diuretic, continue the initial dose for at least 5 days, after which the initial dose may be adjusted to an optimal maintenance dose.Comments:-A second diuretic that acts more proximally at the renal tubule may be added if adequate diuresis has not been achieved after 5 days. The dose of this drug should remain unchanged if a second diuretic is added.Uses:-Treatment of edematous conditions in patients with congestive heart failure who are only partially responsive to or intolerant of other therapeutic measures or who are taking digitalis when other therapies are considered inappropriate.-Treatment of edematous conditions in patients with liver cirrhosis accompanied by edema and/or ascites. -Treatment of edematous conditions in patients with nephrotic syndrome when treatment of the underlying disease, restriction of fluid and sodium intake, and the use of other diuretics do not provide an adequate response. Usual Adult Dose for Hypertension: Initial dose: 50 to 100 mg orally per day in single or divided doses Duration of therapy: Treatment should be continued for at least 2 weeks to achieve a maximum response. Subsequently, the dose may be adjusted according to patient response. Usual Adult Dose for Congestive Heart Failure: Initial dose: 25 mg orally once a day assuming serum potassium is less than or equal to 5 mEq/L and serum creatinine is less than or equal to 2.5 mg/dL Maintenance dose:-Patients tolerant of initial dose: May increase to 50 mg orally once a day as clinically indicated-Patients intolerant of initial dose: May decrease to 25 mg orally every other dayUse: To increase survival and reduce the need for hospitalization of severe heart failure patients (New York Heart Association [NYHA] class III to IV) when used in addition to standard therapy. Usual Adult Dose for Primary Hyperaldosteronism: Diagnostic dose: -Long test: 400 mg orally per day for 3 to 4 weeks-Short test: 400 mg orally per day for 4 daysMaintenance dose: 100 to 400 mg orally per day until surgery; may be used long-term at the lowest effective dose in patients deemed unsuitable for surgery.Comments:-For the long test, correction of hypokalemia and hypertension provides presumptive evidence of primary hyperaldosteronism.-For the short test, increased serum potassium with this drug and a decrease upon discontinuation provide presumptive evidence of primary hyperaldosteronism.Uses:-Initial diagnostic measure to provide presumptive evidence of primary hyperaldosteronism while patients are on normal diets.-Short-term preoperative treatment of patients with primary hyperaldosteronism.-Long-term maintenance therapy for patients deemed unsuitable for surgery or those with idiopathic hyperaldosteronism. Usual Adult Dose for Hypokalemia: 25 to 100 mg orally per day Uses:-Treatment of patients with hypokalemia when other measures are considered inappropriate or inadequate.-Prophylaxis of hypokalemia in patients taking digitalis when other measures are considered inadequate or inappropriate. Detailed Spironolactone dosage information What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What to avoid Drinking alcohol can increase certain side effects. Do not use potassium supplements or salt substitutes, unless your doctor has told you to. Avoid a diet high in salt. Too much salt will cause your body to retain water and can make this medication less effective. Avoid driving or hazardous activity until you know how spironolactone will affect you. Your reactions could be impaired. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Spironolactone side effects Get emergency medical help if you have signs of an allergic reaction to spironolactone: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: a light-headed feeling, like you might pass out; little or no urination; high potassium level - nausea, weakness, tingly feeling, chest pain, irregular heartbeats, loss of movement; o signs of other electrolyte imbalances - increased thirst or urination, confusion, vomiting, muscle pain, slurred speech, severe weakness, numbness, loss of coordination, feeling unsteady. Common spironolactone side effects may include: breast swelling or tenderness. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect spironolactone? Using spironolactone with other drugs that make you dizzy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety, depression, or seizures. Tell your doctor about all your other medicines, especially: colchicine; digoxin; lithium; loperamide; trimethoprim; heart or blood pressure medicine (especially another diuretic); medicine to prevent a blood clot; or NSAIDs (nonsteroidal anti-inflammatory drugs) - aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others. This list is not complete. Other drugs may interact with spironolactone, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is hydrochlorothiazide and spironolactone? Hydrochlorothiazide is a thiazide diuretic (water pill). Spironolactone is a potassium-sparing diuretic. Hydrochlorothiazide and spironolactone is a combination medicine used to treat fluid retention (edema) in people with congestive heart failure, cirrhosis of the liver, or a kidney disorder called nephrotic syndrome. hydrochlorothiazide and spironolactone also treats high blood pressure (hypertension), or low potassium levels (hypokalemia) caused by using a diuretic. Do not use this medicine for any condition that has not been checked by your doctor. Hydrochlorothiazide and spironolactone may also be used for purposes not listed in this medication guide. Warnings You should not use this medicine if you have kidney problems, Addison's disease, high blood levels of calcium or potassium, an allergy to sulfa drugs, or if you are unable to urinate. Before taking this medicine You should not use hydrochlorothiazide and spironolactone if you are allergic to hydrochlorothiazide or spironolactone, or if you have: kidney disease or urination problems; liver disease; high levels of calcium or potassium in your blood; an allergy to sulfa drugs; or Addison's disease (an adrenal gland disorder). Tell your doctor if you have ever had: cirrhosis or other liver disease; severe kidney disease; asthma or allergies; glaucoma; gout; diabetes; or lupus. In animal studies, spironolactone caused certain types of tumors. It is not known whether tumors could occur in people using this medicine. Ask your doctor about your risk. It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. You should not breastfeed while using this medicine. This medicine is not approved for use by anyone younger than 18 years old. How should I take hydrochlorothiazide and spironolactone? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Do not share this medicine with another person, even if they have the same symptoms you have. You may need frequent medical tests. This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using hydrochlorothiazide and spironolactone. If you need surgery, tell the surgeon ahead of time that you are using hydrochlorothiazide and spironolactone. You may need to stop using the medicine for a short time. If you have high blood pressure, keep using this medicine even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life. Store at room temperature away from moisture and heat. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include confusion, skin rash, nausea, vomiting, diarrhea, dizziness, and drowsiness. What should I avoid while taking hydrochlorothiazide and spironolactone? Hydrochlorothiazide may increase your risk of skin cancer. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors. Your doctor may want you to have skin examinations on a regular basis. Drinking alcohol with hydrochlorothiazide and spironolactone can cause side effects. Do not use potassium supplements or salt substitutes, unless your doctor has told you to. Avoid a diet high in salt. Too much salt will cause your body to retain water and can make this medication less effective. Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired. Hydrochlorothiazide and spironolactone side effects Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling). Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes. Call your doctor at once if you have: a light-headed feeling, like you might pass out; blurred vision, tunnel vision, eye pain, or seeing halos around lights; breast swelling and tenderness; low blood cell counts--easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath; high potassium level--nausea, weakness, tingly feeling, chest pain, irregular heartbeats, loss of movement; low potassium level--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling; or low sodium level --headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady. Common side effects may include: drowsiness, dizziness, lack of energy; leg cramps; weakness; feeling like you might pass out; severe pain in your upper stomach spreading to your back, nausea and vomiting; or electrolyte imbalance. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Hydrochlorothiazide and spironolactone dosing information Usual Adult Dose for Hypertension: Hydrochlorothiazide 50 to 100 mg-Spironolactone 50 to 100 mg orally daily in 1 to 2 divided doses Uses: -Treatment of essential hypertension when other measures are considered inadequate or inappropriate. -Treatment of diuretic-induced hypokalemia in hypertensive patients when other measures are considered inappropriate. -Treatment of hypertension. Usual Adult Dose for Edema: Hydrochlorothiazide 25 to 200 mg-Spironolactone 25 to 200 mg orally daily in 1 to 2 divided doses Usual Adult Dose for Congestive Heart Failure: Hydrochlorothiazide 25 to 200 mg-Spironolactone 25 to 200 mg orally daily in 1 to 2 divided doses Uses: -Management of edema and sodium retention when the patient is only partially responsive to, or is intolerant of, other therapeutic measures. -Treatment of diuretic-induced hypokalemia in patients with congestive heart failure (CHF) when other measures are considered inappropriate. -Treatment of patients with CHF taking digitalis when other therapies are considered inadequate or inappropriate. Usual Adult Dose for Ascites: Hydrochlorothiazide 25 to 200 mg-Spironolactone 25 to 200 mg orally daily in 1 to 2 divided doses Use: Maintenance therapy together with bed rest and fluid and sodium restriction for cirrhosis of the liver accompanied by edema and/or ascites. Usual Adult Dose for Nephrotic Syndrome: Hydrochlorothiazide 25 to 200 mg-Spironolactone 25 to 200 mg orally daily in 1 to 2 divided doses Use: For nephrotic patients when treatment of the underlying disease, restriction of fluid and sodium intake, and the use of other diuretics do not provide an adequate response.   What other drugs will affect hydrochlorothiazide and spironolactone? Using hydrochlorothiazide and spironolactone with other drugs that make you drowsy or lower your blood pressure can worsen these effects. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures. Tell your doctor about all your other medicines, especially: cholestyramine; digoxin; lithium; heart or blood pressure medicine, especially another diuretic; insulin or oral diabetes medicine; medicine to prevent a blood clot; NSAIDs (nonsteroidal anti-inflammatory drugs)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others; or steroid medicine--dexamethasone, prednisone, or others. This list is not complete. Other drugs may affect hydrochlorothiazide and spironolactone, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is Sprintec? Sprintec is a combination birth control pill containing female hormones that prevent ovulation (the release of an egg from an ovary). Sprintec also causes changes in your cervical mucus and uterine lining, making it harder for sperm to reach the uterus and harder for a fertilized egg to attach to the uterus. Sprintec is used as contraception to prevent pregnancy. There are many available brands of this medicine. Not all brands are listed on this leaflet. Sprintec may also be used for purposes not listed in this medication guide. Warnings Do not use birth control pills if you are pregnant or if you have recently had a baby. You should not use birth control pills if you have: uncontrolled high blood pressure, heart disease, coronary artery disease, circulation problems (especially with diabetes), undiagnosed vaginal bleeding, liver disease or liver cancer, severe migraine headaches, if you also take certain hepatitis C medication, if you will have major surgery, if you smoke and are over 35, or if you have ever had a heart attack, a stroke, a blood clot, jaundice caused by pregnancy or birth control pills, or cancer of the breast, uterus/cervix, or vagina. Taking birth control pills can increase your risk of blood clots, stroke, or heart attack. Smoking can greatly increase your risk of blood clots, stroke, or heart attack. You should not take birth control pills if you smoke and are over 35 years old. Before taking this medicine Taking birth control pills can increase your risk of blood clots, stroke, or heart attack. You are even more at risk if you have high blood pressure, diabetes, high cholesterol, or if you are overweight. Your risk of stroke or blood clot is highest during your first year of taking birth control pills. Your risk is also high when you restart birth control pills after not taking them for 4 weeks or longer. Smoking can greatly increase your risk of blood clots, stroke, or heart attack. Your risk increases the older you are and the more you smoke. You should not take combination birth control pills if you smoke and are over 35 years old. Do not use if you are pregnant. Stop using Sprintec and tell your doctor right away if you become pregnant, or if you miss two menstrual periods in a row. If you have recently had a baby, wait at least 4 weeks before taking birth control pills. You should not take birth control pills if you have: untreated or uncontrolled high blood pressure; heart disease (chest pain, coronary artery disease, history of heart attack, stroke, or blood clot); an increased risk of having blood clots due to a heart problem or a hereditary blood disorder; circulation problems (especially if caused by diabetes); a history of hormone-related cancer, or cancer of the breast, uterus/cervix, or vagina; unusual vaginal bleeding that has not been checked by a doctor; liver disease or liver cancer; severe migraine headaches (aura, numbness, vision changes), especially if you are older than 35; or if you take any hepatitis C medication containing ombitasvir/paritaprevir/ritonavir (Technivie). Tell your doctor if you have ever had: heart problems, high blood pressure, or if you are prone to having blood clots; high cholesterol or triglycerides, or if you are overweight; depression; a seizure or migraine headache; diabetes, gallbladder disease, underactive thyroid; liver or kidney disease; jaundice caused by pregnancy or birth control pills; irregular menstrual cycles; or fibrocystic breast disease, lumps, nodules, or an abnormal mammogram. This medicine can slow breast milk production. Tell your doctor if you are breast-feeding. How should I take birth control pills? Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. You may need to use back-up birth control, such as condoms with spermicide, when you first start using this medicine. Follow your doctor's instructions. Take one pill every day, no more than 24 hours apart. When the pills run out, start a new pack the following day. You may get pregnant if you do not take one pill daily. Some birth control packs contain "reminder" pills to keep you on your regular cycle. Your period will usually begin while you are using these reminder pills. You may have breakthrough bleeding, especially during the first 3 months. Tell your doctor if this bleeding continues or is very heavy. Use a back-up birth control if you are sick with severe vomiting or diarrhea. If you need major surgery or will be on long-term bed rest, you may need to stop using this medicine for a short time. Any doctor or surgeon who treats you should know that you are using estradiol and levonorgestrel. While taking birth control pills, you will need to visit your doctor regularly. Store this medicine at room temperature away from moisture and heat.   What happens if I miss a dose? Follow the instructions provided with your medicine. Missing a pill increases your risk of becoming pregnant. If you miss 1 active pill, take 2 pills on the day you remember. Then take 1 pill per day for the rest of the pack. If you miss 2 active pills in a row in Week 1 or 2, take 2 pills per day for 2 days in a row. Then take 1 pill per day for the rest of the pack. Use back-up birth control for at least 7 days following the missed pills. If you miss 2 active pills in a row in Week 3, throw out the pack and start a new pack the same day if you are a Day 1 starter. If you are a Sunday starter, keep taking a pill every day until Sunday. On Sunday, throw out the rest of the pack and start a new pack that day. If you miss 3 active pills in a row in Week 1, 2, or 3, throw out the pack and start a new pack on the same day if you are a Day 1 starter. If you are a Sunday starter, keep taking a pill every day until Sunday. On Sunday, throw out the rest of the pack and start a new pack that day. If you miss 2 or more pills, you may not have a period during the month. If you miss a period for 2 months in a row, call your doctor because you might be pregnant. If you miss a reminder pill, throw it away and keep taking one reminder pill per day until the pack is empty. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking birth control pills? Do not smoke while taking birth control pills, especially if you are older than 35 years of age. Birth control pills will not protect you from sexually transmitted diseases, including HIV and AIDS. Using a condom is the only way to protect yourself from these diseases. Birth control pills side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using birth control pills and call your doctor at once if you have: signs of a stroke--sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance; signs of a blood clot--sudden vision loss, stabbing chest pain, feeling short of breath, coughing up blood, pain or warmth in one or both legs; heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating; liver problems--loss of appetite, upper stomach pain, tiredness, fever, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); severe headache, pounding in your neck or ears; swelling in your hands, ankles, or feet; changes in the pattern or severity of migraine headaches; a breast lump; or symptoms of depression--sleep problems, weakness, tired feeling, mood changes. Common side effects may include: stomach pain, gas, nausea, vomiting; breast tenderness; acne, darkening of facial skin; headache, nervousness, mood changes; problems with contact lenses; changes in weight; breakthrough bleeding; vaginal itching or discharge; or rash. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect birth control pills? Other drugs may affect birth control pills, including prescription and over-the-counter medicines, vitamins, and herbal products. Some drugs can make birth control pills less effective, which may result in pregnancy. Tell your doctor about all your current medicines and any medicine you start or stop using.

What is Sprintec? Sprintec is a combination birth control pill containing female hormones that prevent ovulation (the release of an egg from an ovary). Sprintec also causes changes in your cervical mucus and uterine lining, making it harder for sperm to reach the uterus and harder for a fertilized egg to attach to the uterus. Sprintec is used as contraception to prevent pregnancy. There are many available brands of this medicine. Not all brands are listed on this leaflet. Sprintec may also be used for purposes not listed in this medication guide. Warnings Do not use birth control pills if you are pregnant or if you have recently had a baby. You should not use birth control pills if you have: uncontrolled high blood pressure, heart disease, coronary artery disease, circulation problems (especially with diabetes), undiagnosed vaginal bleeding, liver disease or liver cancer, severe migraine headaches, if you also take certain hepatitis C medication, if you will have major surgery, if you smoke and are over 35, or if you have ever had a heart attack, a stroke, a blood clot, jaundice caused by pregnancy or birth control pills, or cancer of the breast, uterus/cervix, or vagina. Taking birth control pills can increase your risk of blood clots, stroke, or heart attack. Smoking can greatly increase your risk of blood clots, stroke, or heart attack. You should not take birth control pills if you smoke and are over 35 years old. Before taking this medicine Taking birth control pills can increase your risk of blood clots, stroke, or heart attack. You are even more at risk if you have high blood pressure, diabetes, high cholesterol, or if you are overweight. Your risk of stroke or blood clot is highest during your first year of taking birth control pills. Your risk is also high when you restart birth control pills after not taking them for 4 weeks or longer. Smoking can greatly increase your risk of blood clots, stroke, or heart attack. Your risk increases the older you are and the more you smoke. You should not take combination birth control pills if you smoke and are over 35 years old. Do not use if you are pregnant. Stop using Sprintec and tell your doctor right away if you become pregnant, or if you miss two menstrual periods in a row. If you have recently had a baby, wait at least 4 weeks before taking birth control pills. You should not take birth control pills if you have: untreated or uncontrolled high blood pressure; heart disease (chest pain, coronary artery disease, history of heart attack, stroke, or blood clot); an increased risk of having blood clots due to a heart problem or a hereditary blood disorder; circulation problems (especially if caused by diabetes); a history of hormone-related cancer, or cancer of the breast, uterus/cervix, or vagina; unusual vaginal bleeding that has not been checked by a doctor; liver disease or liver cancer; severe migraine headaches (aura, numbness, vision changes), especially if you are older than 35; or if you take any hepatitis C medication containing ombitasvir/paritaprevir/ritonavir (Technivie). Tell your doctor if you have ever had: heart problems, high blood pressure, or if you are prone to having blood clots; high cholesterol or triglycerides, or if you are overweight; depression; a seizure or migraine headache; diabetes, gallbladder disease, underactive thyroid; liver or kidney disease; jaundice caused by pregnancy or birth control pills; irregular menstrual cycles; or fibrocystic breast disease, lumps, nodules, or an abnormal mammogram. This medicine can slow breast milk production. Tell your doctor if you are breast-feeding. How should I take birth control pills? Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. You may need to use back-up birth control, such as condoms with spermicide, when you first start using this medicine. Follow your doctor's instructions. Take one pill every day, no more than 24 hours apart. When the pills run out, start a new pack the following day. You may get pregnant if you do not take one pill daily. Some birth control packs contain "reminder" pills to keep you on your regular cycle. Your period will usually begin while you are using these reminder pills. You may have breakthrough bleeding, especially during the first 3 months. Tell your doctor if this bleeding continues or is very heavy. Use a back-up birth control if you are sick with severe vomiting or diarrhea. If you need major surgery or will be on long-term bed rest, you may need to stop using this medicine for a short time. Any doctor or surgeon who treats you should know that you are using estradiol and levonorgestrel. While taking birth control pills, you will need to visit your doctor regularly. Store this medicine at room temperature away from moisture and heat. Detailed Sprintec dosage information What happens if I miss a dose? Follow the instructions provided with your medicine. Missing a pill increases your risk of becoming pregnant. If you miss 1 active pill, take 2 pills on the day you remember. Then take 1 pill per day for the rest of the pack. If you miss 2 active pills in a row in Week 1 or 2, take 2 pills per day for 2 days in a row. Then take 1 pill per day for the rest of the pack. Use back-up birth control for at least 7 days following the missed pills. If you miss 2 active pills in a row in Week 3, throw out the pack and start a new pack the same day if you are a Day 1 starter. If you are a Sunday starter, keep taking a pill every day until Sunday. On Sunday, throw out the rest of the pack and start a new pack that day. If you miss 3 active pills in a row in Week 1, 2, or 3, throw out the pack and start a new pack on the same day if you are a Day 1 starter. If you are a Sunday starter, keep taking a pill every day until Sunday. On Sunday, throw out the rest of the pack and start a new pack that day. If you miss 2 or more pills, you may not have a period during the month. If you miss a period for 2 months in a row, call your doctor because you might be pregnant. If you miss a reminder pill, throw it away and keep taking one reminder pill per day until the pack is empty. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking birth control pills? Do not smoke while taking birth control pills, especially if you are older than 35 years of age. Birth control pills will not protect you from sexually transmitted diseases, including HIV and AIDS. Using a condom is the only way to protect yourself from these diseases. Birth control pills side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using birth control pills and call your doctor at once if you have: signs of a stroke--sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance; signs of a blood clot--sudden vision loss, stabbing chest pain, feeling short of breath, coughing up blood, pain or warmth in one or both legs; heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating; liver problems--loss of appetite, upper stomach pain, tiredness, fever, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); severe headache, pounding in your neck or ears; swelling in your hands, ankles, or feet; changes in the pattern or severity of migraine headaches; a breast lump; or symptoms of depression--sleep problems, weakness, tired feeling, mood changes. Common side effects may include: stomach pain, gas, nausea, vomiting; breast tenderness; acne, darkening of facial skin; headache, nervousness, mood changes; problems with contact lenses; changes in weight; breakthrough bleeding; vaginal itching or discharge; or rash. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Sprintec side effects (more detail) What other drugs will affect birth control pills? Other drugs may affect birth control pills, including prescription and over-the-counter medicines, vitamins, and herbal products. Some drugs can make birth control pills less effective, which may result in pregnancy. Tell your doctor about all your current medicines and any medicine you start or stop using.

What is sucralfate? Sucralfate is used short-term (up to 8 weeks) to treat an active duodenal ulcer. Sucralfate works mainly in the lining of the stomach and is not highly absorbed into the body. sucralfate adheres to ulcer sites and protects them from acids, enzymes, and bile salts. Sucralfate can heal an active ulcer, but it will not prevent future ulcers from occurring. Sucralfate may also be used for purposes not listed in this medication guide. Warnings The liquid form of sucralfate should never be injected through a needle into the body, or death may occur. Before taking this medicine You should not use sucralfate if you are allergic to it. Tell your doctor if you have ever had: diabetes; kidney disease (or if you are on dialysis); or trouble swallowing tablets. Older adults may be more sensitive to the effects of sucralfate. Tell your doctor if you are pregnant or breastfeeding. Do not give this medicine to a child without medical advice. How should I take sucralfate? Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. Take sucralfate on an empty stomach. Shake the oral suspension (liquid) before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon). If you are diabetic, check your blood sugar regularly. Your doctor may adjust your dose based on your blood sugar levels. The liquid from of this medicine should never be injected through a needle into the body, or death may occur. Sucralfate oral suspension is to be taken only by mouth. It may take 2 to 8 weeks before you receive the full benefit of taking sucralfate. Use this medicine for the full prescribed length of time, even if your symptoms quickly improve. Your doctor may want you to keep taking sucralfate at a lower dose once your active ulcer has healed. Follow your doctor's dosing instructions very carefully. Store at room temperature away from moisture and heat. Do not allow the liquid medicine to freeze. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking sucralfate? Avoid taking any other medications within 2 hours before or after you take sucralfate. Sucralfate can make it harder for your body to absorb other medications you take by mouth. Ask your doctor before using an antacid, and use only the type your doctor recommends. Some antacids can make it harder for sucralfate to work in your stomach. Avoid taking an antacid within 30 minutes before or after taking sucralfate. Sucralfate side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Common side effects may include: constipation, diarrhea; nausea, vomiting, gas, indigestion; itching, rash; dizziness, drowsiness; sleep problems (insomnia); headache; or back pain. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Sucralfate dosing information Usual Adult Dose for Duodenal Ulcer: 1 g orally 4 times a day -Duration of therapy: 4 to 8 weeks Comments: -Each dose should be taken on an empty stomach. -For most patients, treatment should continue for 4 to 8 weeks; however, treatment may be stopped early if healing is demonstrated on x-ray/endoscopic tests. -Antacids may be given, but use should be separated by at least 30 minutes. Use: Short-term treatment of active duodenal ulcers Usual Adult Dose for Duodenal Ulcer Prophylaxis: Oral Tablets: 1 g orally 2 times a day -Duration of therapy: Up to 1 year Comments: -Each dose should be taken on an empty stomach. -Controlled studies did not extend beyond 12 months. Use: Maintenance therapy for patients after healing of acute duodenal ulcers   What other drugs will affect sucralfate? Other drugs may affect sucralfate, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

What is sulfamethoxazole and trimethoprim? Sulfamethoxazole and trimethoprim is a combination antibiotic used to treat ear infections, urinary tract infections, bronchitis, traveler's diarrhea, shigellosis, and Pneumocystis jiroveci pneumonia. Sulfamethoxazole and trimethoprim may also be used for purposes not listed in this medication guide. Warnings Use only as directed. Tell your doctor if you use other medicines or have other medical conditions or allergies. Before taking this medicine You should not use sulfamethoxazole and trimethoprim if you are allergic to sulfamethoxazole or trimethoprim, or if you have: severe liver disease; kidney disease that is not being treated or monitored; anemia (low red blood cells) caused by folic acid deficiency; a history of low blood platelets after taking trimethoprim or any sulfa drug; or if you take dofetilide. May cause birth defects. Do not use if you are pregnant. Tell your doctor if you become pregnant. Do not breastfeed. This medicine should not be given to a child younger than 2 months old. Tell your doctor if you have ever had: kidney or liver disease; a folate (folic acid) deficiency; asthma or severe allergies; HIV or AIDS; a thyroid disorder; malnourishment; alcoholism; an electrolyte imbalance (such as low blood sodium or high potassium); porphyria, or glucose-6-phosphate dehydrogenase (G6PD) deficiency; or if you use a blood thinner (such as warfarin) and you have routine "INR" or prothrombin time tests. How should I use sulfamethoxazole and trimethoprim? Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. Sulfamethoxazole and trimethoprim oral is taken by mouth. Shake the oral suspension (liquid). Measure a dose with the supplied measuring device (not a kitchen spoon). Sulfamethoxazole and trimethoprim injection is given in a vein. Be sure you understand how to properly mix this medicine with a liquid (diluent) and how to store the mixture. Ask your doctor or pharmacist if you don't understand how to use an injection. Prepare an injection only when you are ready to give it. Call your pharmacist if the medicine looks cloudy, has changed colors, or has particles in it. Mixed medicine must be used within 2 to 6 hours depending on the amount of diluent in the mixture. Follow your doctor's instructions. Do not refrigerate mixed medicine. Do not reuse a needle or syringe. Place them in a puncture-proof "sharps" container and dispose of it following state or local laws. Keep out of the reach of children and pets. Drink plenty of fluids to prevent kidney stones. Antibiotic medicines can cause diarrhea. Tell your doctor if you have diarrhea that is watery or bloody. Keep using this medicine even if your symptoms quickly improve. Skipping doses could make your infection resistant to medication. Sulfamethoxazole and trimethoprim will not treat a viral infection (flu or a common cold). You may need blood and urine tests, and this medicine may be stopped based on the results. Store at room temperature away from moisture, heat, and light. Do not refrigerate.   What happens if I miss a dose? Use the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include loss of appetite, vomiting, fever, blood in your urine, yellowing of your skin or eyes, confusion, or loss of consciousness. What should I avoid while using sulfamethoxazole and trimethoprim? If you use the injection form of sulfamethoxazole and trimethoprim, do not eat or drink anything that contains propylene glycol (an ingredient in many processed foods, soft drinks, and medicines). Dangerous effects could occur. Sulfamethoxazole and trimethoprim could make you sunburn more easily. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors. Sulfamethoxazole and trimethoprim side effects Get emergency medical help if you have signs of an allergic reaction (hives, cough, chest pain, shortness of breath, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling). Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, joint pain, muscle aches, severe weakness, pale skin, unusual bruising, or yellowing of your skin or eyes. Call your doctor at once if you have: severe stomach pain, diarrhea that is watery or bloody (even if it occurs months after your last dose); any skin rash, no matter how mild; yellowing of your skin or eyes; a seizure; new or unusual joint pain; increased or decreased urination; swelling, bruising, or irritation around the IV needle; increased thirst, dry mouth, fruity breath odor; new or worsening cough, fever, trouble breathing; high blood potassium--nausea, weakness, tingly feeling, chest pain, irregular heartbeats, loss of movement; low blood sodium--headache, confusion, problems with thinking or memory, weakness, feeling unsteady; or low blood cell counts--fever, chills, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath. Common side effects may include: nausea, vomiting, loss of appetite; or skin rash. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is sulfasalazine? Sulfasalazine is used to treat ulcerative colitis (UC), and to decrease the frequency of UC attacks. Sulfasalazine will not cure ulcerative colitis, but it can reduce the number of attacks you have. Sulfasalazine is also used to treat rheumatoid arthritis in children and adults who have used other arthritis medicines that did not work or have stopped working. Sulfasalazine may also be used for purposes not listed in this medication guide. Warnings You should not use sulfasalazine if you have porphyria, a blockage in your bladder or intestines, or if you are allergic to sulfa drugs, aspirin, or similar medicines called salicylates. Before taking this medicine You should not use sulfasalazine if you are allergic to it, or if you have: a blockage in your bladder or intestines; porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system); an allergy to sulfa drugs; or an allergy to aspirin or other salicylates (such as Nuprin Backache Caplet, Kaopectate, KneeRelief, Pamprin Cramp Formula, Pepto-Bismol, Tricosal, Trilisate, and others). Tell your doctor if you have ever had: frequent infections; asthma; low blood cell counts; or liver or kidney disease. Tell your doctor if you are pregnant. Taking sulfasalazine can make it harder for your body to absorb folic acid, and folic acid helps prevent major birth defects of the baby's brain or spine. You may need to take folic acid supplements if you take sulfasalazine during pregnancy. Follow your doctor's instructions. Sulfasalazine can pass into breast milk and may cause diarrhea or bloody stools in a nursing baby. Tell your doctor if you are breast-feeding. Sulfasalazine is not approved for use by anyone younger than 2 years old. How should I take sulfasalazine? Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. Take sulfasalazine after a meal. Swallow the tablet whole and do not crush, chew, or break it. You will need frequent medical tests. Drink plenty of liquids to keep your kidneys working properly while you are taking sulfasalazine. Sulfasalazine can affect the results of certain medical tests. Tell any doctor who treats you that you are using sulfasalazine. Sulfasalazine may cause your skin or urine to appear orange-yellow in color. Call your doctor if you also have yellowing of your eyes, brown urine, or stomach pain. These may be signs of liver problems. If you are treating arthritis, do not stop using any of your other arthritis medicines until your doctor tells you to. Sulfasalazine may not improve your symptoms right away, and you may still need your other medicines for awhile. Sulfasalazine is only part of a complete treatment for rheumatoid arthritis that may also include rest and physical therapy. Follow your doctor's instructions very closely. Store at room temperature away from moisture and heat.   What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include vomiting, stomach pain, drowsiness, or seizure. What should I avoid while taking sulfasalazine? Follow your doctor's instructions about any restrictions on food, beverages, or activity. Sulfasalazine side effects Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling). Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes. You may get infections more easily, even serious or fatal infections. Call your doctor right away if you have signs of infection such as: fever, chills, sore throat; mouth sores, red or swollen gums; pale skin, easy bruising, unusual bleeding; or chest discomfort, wheezing, dry cough or hack, rapid weight loss. Also call your doctor at once if you have: fever with headache, rash, and vomiting; a skin rash, no matter how mild; severe nausea or vomiting when you first start taking sulfasalazine; little or no urination, urine that looks foamy; puffy eyes, swelling in your ankles or feet, weight gain; or liver problems--loss of appetite, stomach pain (upper right side), dark urine, jaundice (yellowing of the skin or eyes). Common side effects may include: nausea, vomiting, upset stomach, loss of appetite; headache; rash; or low sperm count in men. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect sulfasalazine? Other drugs may affect sulfasalazine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

What is sulfasalazine? Sulfasalazine is used to treat ulcerative colitis (UC), and to decrease the frequency of UC attacks. Sulfasalazine will not cure ulcerative colitis, but it can reduce the number of attacks you have. Sulfasalazine is also used to treat rheumatoid arthritis in children and adults who have used other arthritis medicines that did not work or have stopped working. Sulfasalazine may also be used for purposes not listed in this medication guide. Warnings You should not use sulfasalazine if you have porphyria, a blockage in your bladder or intestines, or if you are allergic to sulfa drugs, aspirin, or similar medicines called salicylates. Before taking this medicine You should not use sulfasalazine if you are allergic to it, or if you have: a blockage in your bladder or intestines; porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system); an allergy to sulfa drugs; or an allergy to aspirin or other salicylates (such as Nuprin Backache Caplet, Kaopectate, KneeRelief, Pamprin Cramp Formula, Pepto-Bismol, Tricosal, Trilisate, and others). Tell your doctor if you have ever had: frequent infections; asthma; low blood cell counts; or liver or kidney disease. Tell your doctor if you are pregnant. Taking sulfasalazine can make it harder for your body to absorb folic acid, and folic acid helps prevent major birth defects of the baby's brain or spine. You may need to take folic acid supplements if you take sulfasalazine during pregnancy. Follow your doctor's instructions. Sulfasalazine can pass into breast milk and may cause diarrhea or bloody stools in a nursing baby. Tell your doctor if you are breast-feeding. Sulfasalazine is not approved for use by anyone younger than 2 years old. How should I take sulfasalazine? Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. Take sulfasalazine after a meal. Swallow the tablet whole and do not crush, chew, or break it. You will need frequent medical tests. Drink plenty of liquids to keep your kidneys working properly while you are taking sulfasalazine. Sulfasalazine can affect the results of certain medical tests. Tell any doctor who treats you that you are using sulfasalazine. Sulfasalazine may cause your skin or urine to appear orange-yellow in color. Call your doctor if you also have yellowing of your eyes, brown urine, or stomach pain. These may be signs of liver problems. If you are treating arthritis, do not stop using any of your other arthritis medicines until your doctor tells you to. Sulfasalazine may not improve your symptoms right away, and you may still need your other medicines for awhile. Sulfasalazine is only part of a complete treatment for rheumatoid arthritis that may also include rest and physical therapy. Follow your doctor's instructions very closely. Store at room temperature away from moisture and heat.   What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include vomiting, stomach pain, drowsiness, or seizure. What should I avoid while taking sulfasalazine? Follow your doctor's instructions about any restrictions on food, beverages, or activity. Sulfasalazine side effects Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling). Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes. You may get infections more easily, even serious or fatal infections. Call your doctor right away if you have signs of infection such as: fever, chills, sore throat; mouth sores, red or swollen gums; pale skin, easy bruising, unusual bleeding; or chest discomfort, wheezing, dry cough or hack, rapid weight loss. Also call your doctor at once if you have: fever with headache, rash, and vomiting; a skin rash, no matter how mild; severe nausea or vomiting when you first start taking sulfasalazine; little or no urination, urine that looks foamy; puffy eyes, swelling in your ankles or feet, weight gain; or liver problems--loss of appetite, stomach pain (upper right side), dark urine, jaundice (yellowing of the skin or eyes). Common side effects may include: nausea, vomiting, upset stomach, loss of appetite; headache; rash; or low sperm count in men. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect sulfasalazine? Other drugs may affect sulfasalazine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

What is sumatriptan injection? Sumatriptan is a headache medicine that narrows blood vessels around the brain. Sumatriptan also reduces substances in the body that can trigger headache pain, nausea, sensitivity to light and sound, and other migraine symptoms. Sumatriptan is used to treat migraines and cluster headaches in adults. Sumatriptan will only treat a headache. sumatriptan will not prevent headaches or reduce the number of attacks. Sumatriptan should not be used to treat a common tension headache, or a headache that causes loss of movement on one side of your body. Use this medicine only if your condition has been confirmed by a doctor as migraine headaches. Sumatriptan may also be used for purposes not listed in this medication guide. Warnings You should not use sumatriptan if you have ever had heart disease, coronary artery disease, blood circulation problems, Wolff-Parkinson-White syndrome, uncontrolled high blood pressure, severe liver disease, a heart attack or stroke, or if your headache seems to be different from your usual migraine headaches. Do not use this medicine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine. Do not use sumatriptan within 24 hours before or after using another migraine headache medicine. Before taking this medicine You should not use sumatriptan if you are allergic to it, if you have a headache that seems different from your usual migraine headaches, or if you have ever had: heart problems, or a stroke (including "mini-stroke"); coronary artery disease, angina (chest pain), blood circulation problems, lack of blood supply to the heart; circulation problems affecting your legs, arms, stomach, intestines, or kidneys; a heart disorder called Wolff-Parkinson-White syndrome; uncontrolled high blood pressure; or severe liver disease. Do not use sumatriptan if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others. Tell your doctor if you have ever had: liver or kidney disease; epilepsy or other seizure disorder; high blood pressure, a heart rhythm disorder; or risk factors for coronary artery disease (such as diabetes, menopause, smoking, being overweight, having high blood pressure or high cholesterol, having a family history of coronary artery disease, or being older than 40 and a man). It is not known whether sumatriptan will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. Sumatriptan can pass into breast milk. Do not breast-feed within 12 hours after using sumatriptan. If you use a breast pump during this time, throw out any milk you collect. Do not feed it to your baby. Sumatriptan injection is not approved for use by anyone younger than 18 years old. How should I use sumatriptan injection? Use sumatriptan as soon as you notice headache symptoms. Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. Never use more than your recommended dose. Overuse of migraine headache medicine can make headaches worse. Tell your doctor if the medicine seems to stop working as well in treating your migraine attacks. Sumatriptan is injected under the skin. A healthcare provider may teach you how to properly use the medication by yourself. This medicine comes in a vial (bottle), a needle-free injector device, or a prefilled cartridge for an auto-injector syringe. Each type is for one use only. Read and carefully follow any Instructions for Use provided with your medicine. Do not use sumatriptan if you don't understand all instructions for proper use. Ask your doctor or pharmacist if you have questions. Prepare your injection only when you are ready to give it. Do not use a vial if the medicine looks cloudy, has changed colors, or has particles in it. Call your pharmacist for new medicine. After an injection: If your headache does not completely go away, call your doctor before using a second injection. If your headache goes away and then comes back, use a second injection if it has been at least 1 hour since your first injection. Do not use more than 2 injections in 24 hours. Call your doctor if your symptoms do not improve. Store at room temperature away from moisture, heat, and light. Throw away any unused medicine after the expiration date on the label has passed. Use a needle and syringe only once and then place them in a puncture-proof "sharps" container. Follow state or local laws about how to dispose of this container. Keep it out of the reach of children and pets.   What happens if I miss a dose? Since sumatriptan is used when needed, it does not have a daily dosing schedule. Call your doctor if your symptoms do not improve after using sumatriptan. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include tremors, skin redness in your arms or legs, weakness, loss of coordination, breathing problems, blue-colored lips or fingernails, vision problems, or a seizure (convulsions). What should I avoid while using sumatriptan injection? Do not use sumatriptan within 24 hours before or after using another migraine headache medicine, including: sumatriptan tablets or nasal spray, almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, zolmitriptan; or ergot medicine such as dihydroergotamine, ergotamine, ergonovine, or methylergonovine. Avoid driving or hazardous activity until you know how sumatriptan will affect you. Your reactions could be impaired. Sumatriptan injection side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using sumatriptan and call your doctor at once if you have: sudden and severe stomach pain and bloody diarrhea; severe chest pain, shortness of breath, irregular heartbeats; a seizure (convulsions); blood circulation problems in your legs or feet--cramps, tight or heavy feeling, numbness or tingling, muscle weakness, burning pain, cold feeling, color changes (pale or blue), hip pain; heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating; high levels of serotonin in the body--agitation, hallucinations, fever, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, fainting; increased blood pressure--severe headache, blurred vision, pounding in your neck or ears, anxiety, nosebleed; or signs of a stroke--sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance. Common side effects may include: numbness, tingling, warmth, redness, or burning sensation; pressure or heavy feeling in any part of your body; dizziness, drowsiness, feeling weak or tired; neck pain or stiffness; or pain or redness where the medicine was injected. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect sumatriptan injection? Using sumatriptan while you are using certain other medicines can cause high levels of serotonin to build up in your body, a condition called "serotonin syndrome," which can be fatal. Tell your doctor if you also use: medicine to treat depression or a psychiatric disorder; medicine for Parkinson's disease; medicine for serious infections; herbal products; stimulant medicine; opioid medicine; or medicine to prevent nausea and vomiting. This list is not complete. Other drugs may affect sumatriptan, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is tacrolimus? Tacrolimus is used together with other medicines in people who have had a heart, kidney, liver, or lung transplant. Tacrolimus weakens your immune system to prevent your body from "rejecting" the transplanted organ. Tacrolimus may also be used for purposes not listed in this medication guide. Warnings Tacrolimus may increase your risk of developing a serious infection, skin cancer, or lymphoma. Talk with your doctor about the risks and benefits of using tacrolimus. Call your doctor right away if you have any signs of infection such as fever, chills, flu symptoms, cough, sweating, painful skin sores, skin warmth or redness, or muscle aches. Before taking this medicine You should not use this medicine if you are allergic to tacrolimus or hydrogenated castor oil, or if you have used cyclosporine (Neoral, Sandimmune, Gengraf) within the past 24 hours. Using tacrolimus may increase your risk of developing serious infections or certain types of cancer, such as lymphoma or skin cancer. Your risk may be higher if you are treated over long periods of time with drugs that weaken the immune system. Ask your doctor about this risk and about symptoms to watch for. Some people taking tacrolimus after a kidney transplant have developed diabetes. This effect has been seen most commonly in people who are Hispanic or African-American. Tell your doctor if you have ever had: problems with your liver, kidney, or heart that are not related to your transplant; long QT syndrome (in you or a family member); or if you are scheduled to receive a vaccine; Tell your doctor if you plan to get pregnant. Tacrolimus may harm an unborn baby, and can worsen conditions such as diabetes or high blood pressure in the mother. Use effective birth control before and during treatment with tacrolimus. If you are pregnant, your name may be listed on a pregnancy registry to track the effects of tacrolimus on the baby. If you are a man, use birth control before and during treatment with tacrolimus if your sex partner is able to get pregnant. Pregnancy may be less likely to occur while the mother or the father is using this medicine. Both men and women should still use birth control to prevent pregnancy because the medicine can harm an unborn baby. Ask a doctor if it is safe to breastfeed while using this medicine. How should I take tacrolimus? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. You may receive an injection of tacrolimus shortly after your transplant. Tacrolimus injection is given until you are ready to take the pill form of tacrolimus. Take oral tacrolimus at the same time each day, with a full glass of water. Swallow the tablet or capsule whole and do not crush, chew, break, or open it. Mix tacrolimus oral granules with water right before you take them. Do not save this mixture for later use. Do not get the powder or mixture on your skin or in your eyes. If this happens, wash your skin with soap and water or rinse your eyes with water. Take Astragraf XL or Envarsus XR in the morning on an empty stomach, at least 1 hour before or 2 hours after a meal. You may take Prograf with or without food, but take it the same way each time. Your dose needs may change if you switch to a different brand, strength, or form of tacrolimus. All forms of tacrolimus are not equivalent and may not have the same dose or schedule. Avoid medication errors by using only the form and strength your doctor prescribes. You will need frequent medical tests, and your blood pressure will need to be checked often. Store at room temperature away from moisture and heat.   What happens if I miss a dose? For Prograf: Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. For Astragraf XL: Take the medicine as soon as you can, but skip the missed dose if you are more than 14 hours late for the dose. For Envarsus XR: Take the medicine as soon as you can, but skip the missed dose if you are more than 15 hours late for the dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking tacrolimus? Avoid receiving a "live" vaccine. The vaccine may not work as well while you are using tacrolimus. Live vaccines include measles, mumps, rubella (MMR), rotavirus, typhoid, yellow fever, varicella (chickenpox), and zoster (shingles). Grapefruit may interact with tacrolimus and cause side effects. Avoid consuming grapefruit products. Tacrolimus side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. You may get infections more easily, even serious or fatal infections. Call your doctor right away if you have signs of infection such as: fever, chills, flu symptoms, cough, sweating, painful skin sores, skin warmth or redness, or muscle aches. Also call your doctor at once if you have: general ill feeling, pain or swelling near your transplanted organ; headaches, vision changes, pounding in your neck or ears; confusion, behavior changes; tremors, a seizure; fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness (like you might pass out); chest pain, cough, trouble breathing (even while lying down); high blood sugar--increased thirst, increased urination, hunger, fruity breath odor, nausea, loss of appetite, drowsiness, confusion; high potassium level--nausea, weakness, chest pain, irregular heartbeats, loss of movement; kidney problems--swelling, urinating less, feeling tired or short of breath; low magnesium or phosphate--bone pain, jerky muscle movements, muscle weakness or limp feeling, slow reflexes; or low blood cell counts--fever, flu symptoms, tiredness, pale skin, cold hands and feet. Common side effects may include: low blood cell counts, infections; fever; nausea, diarrhea, constipation, stomach pain; weakness, pain; fluid around your heart; tremors; headache; cough, breathing problems; high blood sugar, high potassium levels, high cholesterol or triglycerides levels; low levels of magnesium or phosphate; numbness or tingling in your hands and feet; sleep problems (insomnia); or swelling in your hands, legs, ankles, or feet. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect tacrolimus? Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective. Tacrolimus can harm your kidneys, especially if you also use certain medicines for infections, cancer, osteoporosis, organ transplant rejection, bowel disorders, high blood pressure, or pain or arthritis (including Advil, Motrin, and Aleve). Tell your doctor about all your current medicines. Many drugs can affect tacrolimus, especially: amiodarone; cisplatin; cyclosporine; sirolimus; antibiotic, antifungal, or antiviral medicines; or heart or blood pressure medication, such as a diuretic or "water pill." This list is not complete and many other drugs may affect tacrolimus. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is tadalafil? Tadalafil relaxes muscles of the blood vessels and increases blood flow to particular areas of the body. Tadalafil under the name of Cialis is used to treat erectile dysfunction (impotence) and symptoms of benign prostatic hypertrophy (enlarged prostate). Another brand of tadalafil is Adcirca, which is used to treat pulmonary arterial hypertension and improve exercise capacity in men and women. Warnings Do not take tadalafil if you are also using a nitrate drug for chest pain or heart problems, including nitroglycerin, isosorbide dinitrate, isosorbide mononitrate, and some recreational drugs such as "poppers". Taking tadalafil with a nitrate medicine can cause a sudden and serious decrease in blood pressure. Some medicines can cause unwanted or dangerous effects when used with tadalafil. Tell your doctor about all your current medicines, especially riociguat (Adempas). Contact your doctor or seek emergency medical attention if your erection is painful or lasts longer than 4 hours. A prolonged erection (priapism) can damage the penis. Get medical help at once if you have nausea, chest pain, or dizziness during sex. Stop using tadalafil and get emergency medical help if you have sudden vision loss. Before taking this medicine You should not take tadalafil if you are allergic to it. Taking tadalafil with certain other medicines can cause a sudden and serious decrease in blood pressure. Do not take this medicine if you also use: riociguat (to treat pulmonary arterial hypertension); or a nitrate drug (for chest pain or heart problems) such as nitroglycerin, isosorbide dinitrate, isosorbide mononitrate, or recreational drugs such as amyl nitrate or nitrite "poppers". Some tadalafil can remain in your bloodstream for 2 or more days after each dose you take (longer if you have liver or kidney disease). Avoid nitrate use during this time. To make sure this medicine is safe for you, tell your doctor if you have ever had: heart disease or heart rhythm problems; a heart attack or stroke; angina (chest pain), high or low blood pressure; pulmonary hypertension (unless you are taking tadalafil for this); a condition called pulmonary veno-occlusive disease (narrowing of the veins that carry blood from the lungs to the heart); liver or kidney disease (or if you are on dialysis); vision loss, or retinitis pigmentosa (an inherited condition of the eye); a bleeding disorder; a blood cell disorder such as sickle cell anemia, multiple myeloma, or leukemia; a physical deformity of the penis (such as Peyronie's disease), or an erection lasting longer than 4 hours; a stomach ulcer; or health problems that make sexual activity unsafe. Sudden vision loss has occurred in a small number of people taking medicines like tadalafil (Viagra or others). Most of these people already had certain eye problems or risk factors for blood vessel disorders (heart disease, diabetes, high blood pressure, high cholesterol, coronary artery disease, smoking, or being over 50 years old). It is not clear whether the medicine was the actual cause of vision loss. Sudden hearing loss has also been reported with tadalafil. Stop tadalafil and call your doctor immediately for any hearing loss, decrease in hearing, or ringing in the ears. Do not start or stop taking tadalafil during pregnancy without your doctor's advice. Having pulmonary arterial hypertension (PAH) during pregnancy may cause heart failure, stroke, or other medical problems in both mother and baby. Tell your doctor right away if you become pregnant. It may not be safe to breastfeed while using tadalafil. Ask your doctor about any risk. Cialis is not for use in women. Tadalafil is not approved for use by anyone younger than 18 years old. How should I take tadalafil? Tadalafil is usually taken only once per day. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. Tadalafil can be taken with or without food. Do not break or split a Cialis tablet. Swallow it whole. For erectile dysfunction, take Cialis just before sexual activity but not more than once per day. It can be used up to 36 hours before sexual activity. Cialis can help achieve an erection when sexual stimulation occurs. An erection will not occur just by taking a pill. Follow your doctor's instructions. Do not take Cialis for erectile dysfunction if you are taking Adcirca for pulmonary arterial hypertension. Store at room temperature away from moisture and heat.   What happens if I miss a dose? If tadalafil is used as needed, you are not likely to be on a dosing schedule. If you take tadalafil every day and you miss a dose, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What to avoid Drinking alcohol with this medicine can cause a drop in blood pressure, leading to dizziness or fainting. Grapefruit and grapefruit juice may interact with tadalafil and lead to unwanted side effects. Avoid the use of grapefruit products while taking this medicine. Tadalafil side effects Get emergency medical help if you have signs of an allergic reaction to tadalafil: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop and get medical help at once if you have nausea, chest pain, or dizziness during sex. You could be having a life-threatening side effect. Stop using tadalafil and call your doctor at once if you have: a light-headed feeling, like you might pass out; an erection is painful or lasts longer than 4 hours (prolonged erection can damage the penis); vision changes or sudden vision loss; ringing in your ears or sudden hearing loss; or heart attack symptoms - chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating. Common tadalafil side effects may include: headache; flushing (warmth, redness, or tingly feeling); nausea, upset stomach; stuffy nose; or muscle pain, back pain, pain in your arms, legs, or back. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect tadalafil? Tell your doctor about all your current medicines and any you start or stop using, especially: medicines to treat erectile dysfunction or pulmonary arterial hypertension; an antibiotic or antifungal medicine; antiviral medicine to treat hepatitis C or HIV/AIDS; drugs to treat high blood pressure or a prostate disorder; or seizure medicine. This list is not complete. Other drugs may interact with tadalafil, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

What is tamoxifen? Tamoxifen blocks the actions of estrogen, a female hormone. Certain types of breast cancer require estrogen to grow. Tamoxifen is used to treat some types of breast cancer in men and women. Tamoxifen is also used to lower a woman's chance of developing breast cancer if she has a high risk (such as a family history of breast cancer). Warnings Taking tamoxifen may increase your risk of uterine cancer, liver cancer, stroke, or a blood clot in the lung, which can be fatal. Do not use tamoxifen if you are pregnant. It could harm the unborn baby. Use a barrier form of birth control (such as a condom or diaphragm with spermicide) while you are using this medication and for at least 2 months after your treatment ends. You should not use tamoxifen if you are allergic to it, if you have a history of blood clots in your veins or your lungs, or if you are taking a blood thinner such as warfarin (Coumadin). Before using this medicine, tell your doctor if you have liver disease, high triglycerides (a type of fat in the blood), a history of cataract, or a history of stroke or blood clot. Also tell your doctor if you if you are receiving chemotherapy or radiation treatment. If you are taking tamoxifen to reduce your risk of breast cancer, you may need to take your first dose while you are having a menstrual period. You may also need to have a pregnancy test before you start taking this medicine, to make sure you are not pregnant. Follow your doctor's instructions. To make sure this medication is not causing harmful effects, your doctor may want you to have mammograms and to perform routine breast self-exams on a regular basis. Your liver function may also need to be tested. Visit your doctor regularly. Before taking this medicine You should not use tamoxifen if you are allergic to it. Tamoxifen may harm an unborn baby. You may need a pregnancy test to make sure you are not pregnant. Use birth control while using tamoxifen and for at least 2 months after your last dose. Tell your doctor if you become pregnant. To prevent pregnancy while using tamoxifen, use a barrier form of birth control: condom, diaphragm, cervical cap, or contraceptive sponge. Avoid using hormonal birth control, including birth control pills, injections, implants, skin patches, and vaginal rings. You should not use tamoxifen to reduce your risk of breast cancer if you also take warfarin (Coumadin, Jantoven). To make sure tamoxifen is safe for you, tell your doctor if you have: a stroke or blood clot; liver disease; high cholesterol or triglycerides (a type of fat in the blood); cataracts; chemotherapy; or if you also use anastrozole or letrozole. Taking tamoxifen may increase your risk of uterine cancer, liver cancer, stroke, or a blood clot in the lung, which can be fatal. Talk with your doctor about your own risks. Do not breastfeed while using tamoxifen, and for at least 3 months after your last dose. This medicine is not approved for use by anyone younger than 18 years old. How should I take tamoxifen? Take tamoxifen exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Measure liquid medicine with the supplied syringe or a dose-measuring device (not a kitchen spoon). Take with or without food. You may need to keep using this medicine for 5 to 10 years. Have regular physical exams and mammograms, and self-examine your breasts for lumps on a monthly basis while using tamoxifen. This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using tamoxifen. Store at room temperature away from moisture, heat, and light. Do not refrigerate or freeze. Throw away any leftover liquid medicine 3 months after you first opened the bottle. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking tamoxifen? Follow your doctor's instructions about any restrictions on food, beverages, or activity. Tamoxifen side effects Get emergency medical help if you have signs of an allergic reaction to tamoxifen: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Tamoxifen can increase your risk of stroke or blood clots. Call your doctor at once if you have: signs of a stroke - sudden numbness or weakness, severe headache, slurred speech, problems with vision or balance; signs of a blood clot in the lung - chest pain, sudden cough or shortness of breath, dizziness, coughing up blood; or signs of a blood clot deep in the body - pain, swelling, or warmth in one leg. Also call your doctor at once if you have: unusual vaginal bleeding or discharge; blurred vision, eye pain or redness, seeing halos around lights; changes in your menstrual periods; pain or pressure in your pelvic area; a new breast lump; liver problems - nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or high blood calcium - confusion, tiredness, nausea, vomiting, loss of appetite, constipation, increased thirst or urination, weight loss. Common tamoxifen side effects may include: vaginal bleeding or discharge; hot flashes; swelling, weight gain; nausea; or mood changes. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Tamoxifen dosing information Usual Adult Dose for Breast Cancer: Metastatic breast cancer in women and men: 20 to 40 mg orally daily for 5 years; doses greater than 20 mg should be given in divided doses (morning and evening) DCIS following breast surgery and radiation: 20 mg orally daily for 5 years To reduce the incidence of breast cancer in women at high risk for breast cancer: 20 mg orally daily for 5 years Comments: -There are no data to support the use of this drug other than for 5 years. Uses: -Metastatic For metastatic breast cancer in women and men. In premenopausal women with metastatic breast cancer, this drug is an alternative to oophorectomy or ovarian irradiation. Patients whose tumors are estrogen receptor positive are more likely to benefit. -Ductal Carcinoma in Situ (DCIS): In women with DCIS, following breast surgery and radiation, to reduce the risk of invasive breast cancer. -Reduction in Breast Cancer Incidence in High Risk Women: To reduce the incidence of breast cancer in women at high risk. "High risk" is defined as women at least 35 years of age with a 5-year predicted risk of breast cancer greater than or equal to 1.67%, as calculated by the Gail Model. Usual Adult Dose for Breast Cancer -- Adjuvant: 20 mg orally once daily or 10 mg orally 2 times daily Duration of therapy: Up to 5 years Comments: -There are no data to support the use of this drug other than for 5 years. Use: For the treatment of node-positive breast cancer in postmenopausal women following total mastectomy or segmental mastectomy, axillary dissection, and breast irradiation Usual Pediatric Dose for McCune-Albright Syndrome: Girls 2 to 10 years with McCune-Albright Syndrome and precocious puberty: 20 mg orally once daily Duration of therapy: Up to 12 months Use: McCune-Albright Syndrome; precocious puberty Usual Pediatric Dose for Precocious Puberty: Girls 2 to 10 years with McCune-Albright Syndrome and precocious puberty: 20 mg orally once daily Duration of therapy: Up to 12 months Use: McCune-Albright Syndrome; precocious puberty   What other drugs will affect tamoxifen? Many drugs can interact with tamoxifen, and some drugs should not be used at the same time. Tell your doctor about all other medicines you use. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.

What is tamsulosin? Tamsulosin (Flomax) is an alpha-blocker that relaxes the muscles in the prostate and bladder neck, making it easier to urinate. Tamsulosin is used to improve urination in men with benign prostatic hyperplasia (enlarged prostate). Tamsulosin is not FDA approved for use in women or children. Warnings You should not use this medication if you are allergic to tamsulosin. Do not take tamsulosin with other similar medicines such as alfuzosin (Uroxatral), doxazosin (Cardura), prazosin (Minipress), silodosin (Rapaflo), or terazosin (Hytrin). Tamsulosin may cause dizziness or fainting, especially when you first start taking it or when you start taking it again. Be careful if you drive or do anything that requires you to be alert. Avoid standing for long periods of time or becoming overheated during exercise and in hot weather. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. If you stop taking this medicine for any reason, call your doctor before you start taking it again. You may need a dose adjustment. Tamsulosin can affect your pupils during cataract surgery. Tell your eye surgeon ahead of time that you are using this medication. Do not stop using tamsulosin before surgery unless your surgeon tells you to. There are many other drugs that can interact with this medicine. Tell your doctor about all medications you use. Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use. Before taking this medicine You should not use tamsulosin if you are allergic to it. Do not take tamsulosin together with similar medicines such as alfuzosin (Uroxatral), doxazosin (Cardura), prazosin (Minipress), silodosin (Rapaflo), or terazosin (Hytrin). To make sure tamsulosin is safe for you, tell your doctor if you have: liver or kidney disease; a history of prostate cancer; low blood pressure; or an allergy to sulfa drugs. Tamsulosin can affect your pupils during cataract surgery. Tell your eye surgeon ahead of time that you are using this medicine. Do not stop using tamsulosin before surgery unless your surgeon tells you to. Although this medicine is not for use in women, tamsulosin is not expected to harm an unborn baby. If you are a woman using this medication, tell your doctor if you are pregnant or breast-feeding. This medicine is not approved for use by anyone younger than 18 years old. How should I take tamsulosin? Take tamsulosin exactly as it was prescribed for you. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended. Tamsulosin is usually taken once a day, approximately 30 minutes after a meal. Try to take this medication at the same time each day. Do not crush, chew, or open a capsule. Swallow the capsule whole. Tamsulosin lowers blood pressure and may cause dizziness or fainting, especially when you first start taking it, or when you start taking it again. Call your doctor if you have severe dizziness or feel like you might pass out. Some things can cause your blood pressure to get too low. This includes vomiting, diarrhea, heavy sweating, heart disease, dialysis, a low-salt diet, or taking diuretics (water pills). Tell your doctor if you have a prolonged illness that causes diarrhea or vomiting. Your blood pressure will need to be checked often. You will also need to be checked for prostate cancer before and during treatment with tamsulosin. You may feel very dizzy when you first wake up. Be careful when standing or sitting up from a lying position. If you stop taking tamsulosin for any reason, call your doctor before you start taking it again. You may need a dose adjustment. Store at room temperature away from moisture and heat. Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions. Dosing information Usual Adult Dose for Benign Prostatic Hyperplasia: Initial Dose: 0.4 mg orally once a day Maximum Dose: 0.8 mg orally once a day Comments: -If use is discontinued or interrupted for several days at either the 0.4 mg or 0.8 mg dose, treatment should be initiated again with the 0.4 mg once a day dose. Use: Treatment of the signs and symptoms of benign prostatic hyperplasia (BPH)   What happens if I miss a dose? Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. If you miss your doses for several days in a row, contact your doctor before restarting the medication. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What to avoid Tamsulosin may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall. Dizziness or severe drowsiness can cause falls, accidents, or severe injuries. To prevent dizziness, avoid standing for long periods of time or becoming overheated during exercise and in hot weather. Drinking alcohol can increase certain side effects of tamsulosin. Tamsulosin side effects Get emergency medical help if you have signs of an allergic reaction to tamsulosin: hives, rash, itching; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using this medicine and call your doctor at once if you have: a light-headed feeling, like you might pass out; penis erection that is painful or lasts 4 hours or longer; or severe skin reaction - fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling. Common tamsulosin side effects may include: low blood pressure; dizziness, drowsiness, weakness; nausea, diarrhea; headache, chest pain; abnormal ejaculation, decreased amount of semen; back pain; blurred vision; tooth problems; fever, chills, body aches, flu symptoms; runny or stuffy nose, sinus pain, sore throat, cough; sleep problems (insomnia); or decreased interest in sex. This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect tamsulosin? Tell your doctor about all medicines you use, and those you start or stop using during your treatment with, especially: blood pressure medicine. This list is not complete. Other drugs may interact with tamsulosin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

What is tazarotene topical? Tazarotene is a compound similar to vitamin A. It helps the skin to renew itself more quickly and may improve the appearance and texture of skin. Tazarotene topical is available in a cream, gel, lotion, or foam. The Avage brand of tazarotene cream is used to reduce the appearance of fine wrinkles on the face, mottled light and dark skin patches on the face, and benign facial lentigines (non-cancerous freckles) in adults and adolescents who are at least 17 years old. The Fabior and Tazorac brands of tazarotene topical are used to treat acne vulgaris in adults and adolescents who are at least 12 years old. The Arazlo brand of tazarotene topical is used to treat acne vulgaris in adults and adolescents who are at least 9 years old. Tazorac is also used to treat plaque psoriasis (raised, silvery flaking of the skin) in adults. Warnings Tazarotene can cause birth defects. Do not use if you are pregnant. Use effective birth control to prevent pregnancy. Stop using tazarotene and tell your doctor right away if you become pregnant, if you stop using birth control, or if you miss a menstrual period. You may get sunburned more easily. Avoid sun, sunlamps, and tanning beds. Use sunscreen and wear clothing and eyewear that protects you from the sun. Some weather conditions may irritate the skin. Your skin may look worse before it looks better. Tazarotene may cause harm if swallowed. If tazarotene cream is swallowed, call a doctor or poison control center right away. Before taking this medicine You should not use tazarotene topical if you are allergic to it, or if you are pregnant or may become pregnant. You must have a negative pregnancy test within 2 weeks before starting this treatment. To make sure tazarotene is safe for you, tell your doctor if you have ever had: eczema, sunburn, or another skin condition; skin cancer; lentigo maligna (a type of skin cancer); an allergic reaction to a skin product; or if you work outdoors. Do not use tazarotene if you are pregnant. It could harm the unborn baby or cause birth defects. Use effective birth control to prevent pregnancy while you are using this medicine. Stop using tazarotene and tell your doctor right away if you become pregnant, if you stop using birth control, or if you miss a menstrual period. It may not be safe to breastfeed while using tazarotene. Ask your doctor about any risk. Avage should not be used on anyone younger than 17 years old. Fabior or Tazorac should not be used to treat acne in a child younger than 12 years old. Fabior should not be used to treat psoriasis in anyone under 18 years old. How should I use tazarotene topical? Tazarotene is usually applied once daily in the evening or at bedtime. Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. Do not take by mouth. Topical medicine is for use only on the skin. Do not use tazarotene topical on open wounds or on sunburned, windburned, dry, chapped, or irritated skin. If this medicine gets in your eyes, nose, mouth, rectum, or vagina, rinse with water. Also avoid using this medicine in wounds or on areas of eczema. Wait until these conditions have fully healed before using tazarotene. Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions. Women who use tazarotene topical should start the medication during a menstrual period. Avoid applying the medication to unaffected areas. If medication accidentally gets on areas that do not need treatment, wash it off. Shake the Fabior foam well just before each use. Your skin may be more sensitive to weather extremes such as cold and wind during treatment with tazarotene. Protect your skin with clothing and use a moisturizing cream or lotion as needed. Store at room temperature, away from moisture and heat. Do not freeze. Fabior foam is flammable. Do not use near high heat or open flame. The canister may explode if it gets too hot. Do not puncture or burn an empty foam canister. Store the bottle in an upright position. Tazarotene dosing information Usual Adult Dose of Tazarotene for Plaque Psoriasis: Initial dose: Apply a thin film of 0.05% gel or cream once a day in the evening to cover only the psoriatic lesions -Increase to 0.1% if tolerated and medically indicated Comments: -Apply to dry skin; if a bath or shower is taken prior to application, allow time for skin to dry before applying; if emollients are used, they should be applied at least 1 hour prior. -Avoid applying gel or cream on unaffected skin as it may be more susceptible to irritation. -The safety of gel use on more than 20% body surface area has not been established and is not recommended. Uses: -For the topical treatment of plaque psoriasis Usual Adult Dose of Tazarotene for Acne: Apply a thin layer of 0.1% gel/cream/foam once a day in the evening to cover acne lesions Comments: -Cleanse the face gently and dry before application. -Use sunscreen and wear protective clothing while using this drug. Use: For the topical treatment of acne vulgaris Usual Adult Dose of Tazarotene for Skin Pigmentation Disorder: Apply pea-sized amount once a day at bedtime to lightly cover entire face, including the eyelids, if desired Comments: -Remove makeup and after washing face and allow skin to completely dry before applying; emollients/moisturizers may be applied before this cream, however, allow to absorb and completely dry before applying this cream; facial moisturizers may be used as frequently as desired. -This cream does not eliminate or prevent wrinkles or restore more youthful skin. -This cream does not reverse photoaging or repair sun damaged skin; it does not mitigate coarse or deep wrinkling, tactile roughness, telangiectasia, skin laxity, keratinocytic atypia, melanocytic atypia, or dermal elastosis. -The safety and effectiveness for the prevention and treatment of actinic keratoses, skin neoplasms, or lentigo maligna have not been established. Use: As an adjunctive agent for use in the mitigation (palliation) of facial fine wrinkling, facial, mottled hyper and hypopigmentation and benign facial lentigines in patients who use comprehensive skin care and sunlight avoidance programs. Usual Pediatric Dose for Acne: Age: 12 years or older: Apply a thin layer of 0.1% gel/cream/foam once a day in the evening to cover acne lesions Comments: -Cleanse the face gently and dry before application. -Use sunscreen and wear protective clothing while using this drug. Use: For the topical treatment of acne vulgaris Usual Pediatric Dose for Plaque Psoriasis: Age: 12 years or older: Initial dose: Apply a thin film of 0.05% gel or cream once a day in the evening to cover only the psoriatic lesions -Increase to 0.1% if tolerated and medically indicated Comments: -Apply to dry skin; if a bath or shower is taken prior to application, allow time for skin to dry before applying; if emollients are used, they should be applied at least 1 hour prior. -Avoid applying gel or cream on unaffected skin as it may be more susceptible to irritation. -The safety of gel use on more than 20% body surface area has not been established and is not recommended. Uses: -For the topical treatment of plaque psoriasis   What happens if I miss a dose? Apply the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not apply two doses at one time. What happens if I overdose? An overdose of tazarotene may cause severe skin discomfort. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medicine. What should I avoid while using tazarotene? Avoid applying the medication to unaffected areas. If medication accidentally gets on areas that do not need treatment, wash it off. Avoid using other skin medications on the areas you treat with tazarotene topical unless your doctor tells you to. Avoid exposure to sunlight or tanning beds. tazarotene can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors. Avoid using skin products that can cause irritation, such as harsh soaps, shampoos, hair coloring or permanent chemicals, hair removers or waxes, or skin products with alcohol, spices, astringents, or lime. Rinse with water if tazarotene gets in your eyes. Tazarotene topical side effects Get emergency medical help if you have signs of an allergic reaction to tazarotene: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using tazarotene and call your doctor at once if you have: severe skin irritation (pain, dryness, flaking, peeling, burning, stinging, itching) after applying the medicine; blistering or peeling skin; severe redness or discomfort; or swelling, warmth, oozing, or other signs of skin infection. Common tazarotene side effects may include: dry, scaly, or peeling skin; skin pain, redness or burning; or itching or other irritation of treated skin. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect tazarotene topical? If you also use a benzoyl peroxide acne medication, do not use it at the same time you use tazarotene topical. Apply one medication only in the morning and the other only in the evening. Tell your doctor about all your other medicines, especially: an antibiotic or other medicine that can make your skin more sensitive to sunlight. This list is not complete. Other drugs may interact with tazarotene, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is telmisartan? Telmisartan is an angiotensin II receptor blocker (sometimes called an ARB) that is used to treat high blood pressure (hypertension). Lowering blood pressure may lower your risk of a stroke or heart attack. Telmisartan is also used to reduce the risk of stroke, heart attack, or death from heart problems in people who are at least 55 years old with risk factors for serious heart disorders. Telmisartan may also be used for purposes not listed in this medication guide. Warnings Do not use if you are pregnant. Stop using telmisartan and tell your doctor right away if you become pregnant. If you have diabetes, do not take telmisartan with any medicine that contains aliskiren (a blood pressure medicine). Before taking this medicine You should not use telmisartan if you are allergic to it. If you have diabetes, do not take telmisartan with any medicine that contains aliskiren (a blood pressure medicine). You may also need to avoid taking telmisartan with aliskiren if you have kidney disease. Tell your doctor if you have ever had: a heart condition other than one being treated with telmisartan; liver disease; kidney disease (or if you are on dialysis); or if you are on a low-salt diet. Do not use if you are pregnant. Stop using the medicine and tell your doctor right away if you become pregnant. Telmisartan can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. If you plan to get pregnant, ask your doctor for a safer medicine to use before and during pregnancy. Having high blood pressure during pregnancy may cause complications in the mother and the baby. You should not breastfeed while using telmisartan. How should I take telmisartan? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Take telmisartan at the same time each day, with or without food. Call your doctor if you are sick with vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking telmisartan. It may take 2 to 4 weeks before your blood pressure is under control. Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life. Treatment may also include diet, exercise, lowering cholesterol, not smoking, and controlling diabetes. Your blood pressure will need to be checked often. Your liver or kidney function may also need to be checked. Store at room temperature away from moisture and heat. Keep the tablets in their original package or container, along with any packet or canister of moisture-absorbing preservative. Keep this medicine in its original packaging until you're ready to take a tablet. Tear or cut one tablet blister from the package, peel back the paper liner, and push the tablet through the foil. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking telmisartan? Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Do not use potassium supplements or salt substitutes, unless your doctor has told you to. Telmisartan side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Also call your doctor at once if you have: a light-headed feeling, like you might pass out; little or no urination; swelling in your feet or ankles, rapid weight gain; unusual pain or tightness in your lower body; a skin ulcer; or high potassium level--nausea, weakness, tingly feeling, chest pain, irregular heartbeats, loss of movement. Common side effects may include: stuffy nose, sinus pain; back pain; or diarrhea. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Telmisartan dosing information Usual Adult Dose for Hypertension: Initial dose: 40 mg orally once a day Maintenance dose: 40 to 80 mg orally once a day Comments: Most of the antihypertensive effect is present within 2 weeks; maximum blood pressure reduction at a given dose is generally observed within 4 weeks of starting that dose. Usual Adult Dose for Cardiovascular Risk Reduction: 80 mg orally once a day Comments: -It is unknown whether doses lower than 80 mg are effective in reducing the risk of cardiovascular morbidity and mortality. -When initiating this drug for cardiovascular risk reduction, monitoring of blood pressure is recommended, and if appropriate, adjustment of other medications that lower blood pressure. Use: Reduction of risk of myocardial infarction, stroke, or death from cardiovascular causes in patients 55 years or older at high risk of developing major cardiovascular events who are unable to take angiotensin-converting enzyme (ACE) inhibitors. High risk for cardiovascular events can be evidenced by a history of coronary artery disease, peripheral arterial disease, stroke, transient ischemic attack, or high-risk diabetes (insulin-dependent or non-insulin dependent) with evidence of end-organ damage.   What other drugs will affect telmisartan? Tell your doctor about all your other medicines, especially: digoxin; lithium; a diuretic or "water pill" or other blood pressure medicine; or NSAIDs (nonsteroidal anti-inflammatory drugs)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others; This list is not complete. Other drugs may affect telmisartan, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here,  

What is hydrochlorothiazide and telmisartan? Hydrochlorothiazide is a diuretic (water pill). Telmisartan is an angiotensin II receptor blocker (sometimes called an ARB blocker). Hydrochlorothiazide and telmisartan is a combination medicine is used to treat high blood pressure (hypertension). Lowering blood pressure may lower your risk of a stroke or heart attack. Hydrochlorothiazide and telmisartan may also be used for purposes not listed in this medication guide. Warnings Do not use if you are pregnant. Stop using the medicine and tell your doctor right away if you become pregnant. You should not use hydrochlorothiazide and telmisartan if you are unable to urinate. If you have diabetes, do not use hydrochlorothiazide and telmisartan together with any medication that contains aliskiren (a blood pressure medicine). Before taking this medicine You should not use this medicine if you are allergic to hydrochlorothiazide or telmisartan, if you are unable to urinate. If you have diabetes, do not use hydrochlorothiazide and telmisartan together with any medication that contains aliskiren (a blood pressure medicine). You may also need to avoid taking hydrochlorothiazide and telmisartan with aliskiren if you have kidney disease. Tell your doctor if you have ever had: kidney disease; liver disease; glaucoma; low or high levels of magnesium or potassium in your blood; asthma or allergies; lupus; diabetes; or an allergy to penicillin or sulfa drugs. Do not use if you are pregnant. Stop using the medicine and tell your doctor right away if you become pregnant. Hydrochlorothiazide and telmisartan can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. You should not breastfeed while using this medicine. How should I take hydrochlorothiazide and telmisartan? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. You may take hydrochlorothiazide and telmisartan with or without food. Your blood pressure will need to be checked often. Call your doctor if you are sick with vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking hydrochlorothiazide and telmisartan. This can lead to very low blood pressure, a serious electrolyte imbalance, or kidney failure. If you need surgery or medical tests, tell the surgeon ahead of time that you are using this medicine. It may take up to 4 weeks for this medication to control your blood pressure. Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life. Store at room temperature away from moisture and heat. Keep each tablet in its blister pack until you are ready to take it. Gently push the tablet through the foil to remove it. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include fast or slow heart rate, feeling light-headed, or fainting. What should I avoid while taking hydrochlorothiazide and telmisartan? Hydrochlorothiazide may increase your risk of skin cancer. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors. Your doctor may want you to have skin examinations on a regular basis. Do not use potassium supplements or salt substitutes, unless your doctor has told you to. Drinking alcohol can further lower your blood pressure and may cause side effects. Avoid becoming overheated or dehydrated during exercise, in hot weather, or by not drinking enough fluids. Hydrochlorothiazide and telmisartan side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. In rare cases, hydrochlorothiazide and telmisartan can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, or dark colored urine. Also call your doctor at once if you have: eye pain, vision problems; a light-headed feeling, like you might pass out; jaundice (yellowing of the skin or eyes); swelling in your hands or feet, unusual weight gain; easy bruising, unusual bleeding; or signs of an electrolyte imbalance--dry mouth, increased thirst, drowsiness, confusion, feeling restless, vomiting, muscle pain or weakness, lack of energy, fast heartbeats, little or no urine, or a seizure. Common side effects may include: dizziness, feeling tired; nausea, diarrhea; back pain; or cold or flu symptoms. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Hydrochlorothiazide and telmisartan dosing information Usual Adult Dose for Hypertension: Hydrochlorothiazide 12.5 to 25 mg-Telmisartan 80 mg orally once a day Maximum dose: Hydrochlorothiazide 25 mg-Telmisartan 160 mg orally once a day Comments: -This drug may be substituted for the individual titrated components. -If blood pressure remains uncontrolled by hydrochlorothiazide 25 mg orally once a day monotherapy, may switch to hydrochlorothiazide 12.5 to 25 mg-telmisartan 80 mg orally once a day. Reassess after 2 to 4 weeks; may increase up to hydrochlorothiazide 25 mg-telmisartan 160 mg orally once a day. -If blood pressure is controlled by hydrochlorothiazide 25 mg orally once a day monotherapy, but hypokalemia occurs, may switch to hydrochlorothiazide 12.5 mg-telmisartan 80 mg orally once a day. -If blood pressure remains uncontrolled by telmisartan 80 mg orally once a day monotherapy, may switch to hydrochlorothiazide 12.5 mg-telmisartan 80 mg orally once a day; may titrate up to hydrochlorothiazide 25 mg-telmisartan 160 mg orally once a day, if necessary. Use: Treatment of hypertension; not indicated for initial therapy.   What other drugs will affect hydrochlorothiazide and telmisartan? If you also take cholestyramine or colestipol, avoid taking these medications within 4 hours before or 4 hours after you take hydrochlorothiazide and telmisartan. Tell your doctor about all your other medicines, especially: any other heart or blood pressure medications; digoxin; lithium; a diuretic or "water pill"; insulin or oral diabetes medicine; opioid pain medicine; a sleeping pill; steroid medicine or adrenocorticotrophic hormone (ACTH); a barbiturate such as butabarbital, phenobarbital, or secobarbital; or NSAIDs (nonsteroidal anti-inflammatory drugs)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others. This list is not complete. Other drugs may affect hydrochlorothiazide and telmisartan, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is temazepam? Temazepam is a benzodiazepine (ben-zoe-dye-AZE-eh-peen). It affects chemicals in the brain that may be unbalanced in people with sleep problems (insomnia). Temazepam is used short term to treat insomnia (trouble falling or staying asleep). Temazepam works by slowing down the central nervous system (brain), causing drowsiness which helps patients fall asleep. Warnings Temazepam can slow or stop your breathing, especially if you have recently used an opioid medication, alcohol, or other drugs that can slow your breathing. Never take this medicine if you do not have at least 7 to 8 hours to sleep before being active again. Do not use temazepam if you are pregnant. It can cause birth defects or life-threatening withdrawal symptoms in a newborn. Use effective birth control to prevent pregnancy while taking this medicine. Some people using this medicine have engaged in activity such as driving, eating, or making phone calls and later having no memory of the activity. If this happens to you, stop taking temazepam and talk with your doctor about another treatment for your sleep disorder. Temazepam may be habit-forming and should be used only by the person it was prescribed for. This medicine should never be shared with another person, especially someone who has a history of drug abuse or addiction. MISUSE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it. Temazepam may cause a severe allergic reaction. Stop taking this medicine and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Take this medication only when you are getting ready for several hours of sleep. You may fall asleep very quickly after taking the medicine. Before taking this medicine You should not use temazepam if you are allergic to it. Do not use temazepam if you are pregnant or may become pregnant. This medicine could harm the unborn baby. To make sure temazepam is safe for you, tell your doctor if you have ever had: lung disease or breathing problems; depression, mental illness, suicidal thoughts; alcoholism or drug addiction; or liver or kidney disease. Ask a doctor if it is safe to breastfeed while using this medicine. Valtoco is not approved for use by anyone younger than 18 years old. How should I take temazepam? Take temazepam exactly as prescribed by your doctor. Follow the directions on your prescription label and read all medication guides or instruction sheets. Never use temazepam in larger amounts, or for longer than prescribed. Tell your doctor if you feel an increased urge to use more of this medicine. Never share this medicine with another person, especially someone with a history of drug abuse or addiction. MISUSE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it. Selling or giving away this medicine is against the law. Take this medicine only when you are getting ready for several hours of sleep. You may fall asleep very quickly after taking the medicine. Call your doctor if your insomnia does not improve after taking temazepam for 7 to 10 nights, or if you have any mood or behavior changes. Insomnia can be a symptom of depression, mental illness, or certain medical conditions. Temazepam should be used for only a short time. Do not take this medicine for longer than 2 weeks without your doctor's advice. Do not stop using this medicine without asking your doctor. You may have life-threatening withdrawal symptoms if you stop using the medicine suddenly. Store at room temperature away from moisture and heat. Keep your medicine in a place where no one can use it improperly. Dosing information Usual Adult Dose for Insomnia: 7.5 to 30 mg orally once a day at bedtime Comments: -In transient insomnia, a 7.5 mg dose may be sufficient to improve sleep latency. -In elderly or debilitated patients, therapy should be initiated at 7.5 mg until individual responses are determined. Use: Short-term treatment of insomnia (generally 7 to 10 days)   What happens if I miss a dose? Temazepam is used when needed. If you are on a dosing schedule, skip any missed dose. Take temazepam only when you have time for several hours of sleep. Do not use two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of temazepam can be fatal if you take it with alcohol, opioid medicine, or other drugs that cause drowsiness or slow your breathing. Overdose symptoms may include extreme drowsiness, confusion, or coma. What should I avoid while taking temazepam? Do not drink alcohol. Dangerous side effects or death could occur. You may still feel sleepy the morning after taking temazepam. Wait until you are fully awake before you drive, operate machinery, or do anything that requires you to be awake and alert. Your reactions may be impaired. Temazepam side effects Temazepam may cause a severe allergic reaction. Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; nausea, vomiting; swelling of your face, lips, tongue, or throat. Temazepam can slow or stop your breathing, especially if you have recently used an opioid medication or alcohol. A person caring for you should seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up. Call your doctor at once if you have: confusion, agitation, hallucinations; depressed mood; or thoughts of suicide or hurting yourself. Some people using temazepam have engaged in activity such as driving, eating, walking, making phone calls, or having sex and later having no memory of the activity. Tell your doctor if this happens to you. Drowsiness or dizziness may last longer in older adults. Use caution to avoid falling or accidental injury. Common temazepam side effects may include: drowsiness, tiredness; dizziness; headache; nausea; or feeling nervous. After you stop using temazepam, get medical help right away if you have symptoms such as: unusual muscle movements, being more active or talkative, sudden and severe changes in mood or behavior, confusion, hallucinations, seizures, suicidal thoughts or actions. Some withdrawal symptoms may last up to 12 months or longer after stopping this medicine suddenly. Tell your doctor if you have ongoing anxiety, depression, problems with memory or thinking, trouble sleeping, ringing in your ears, a burning or prickly feeling, or a crawling sensation under your skin. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect temazepam? Taking temazepam with other drugs that make you sleepy or slow your breathing can cause dangerous side effects or death. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures. Other drugs may interact with temazepam, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

What is tenofovir? Tenofovir is an antiviral medicine that is used to treat HIV, the virus that can cause acquired immunodeficiency syndrome (AIDS). Tenofovir is not a cure for HIV or AIDS. Tenofovir is also used to treat chronic hepatitis B. Tenofovir is for use in adults and children at least 2 years old and weighing at least 22 pounds (10 kilograms). Tenofovir may also be used for purposes not listed in this medication guide. Warnings If you've had hepatitis B, it may come back or get worse after you stop using tenofovir. You may need liver function tests for several months. Do not change your dose or stop using a medicine without your doctor's advice. Before taking this medicine You should not take tenofovir if you are allergic to it. Do not take tenofovir together with adefovir (Hepsera), or with combination medicines that contain tenofovir (Atripla, Biktarvy, Cimduo, Complera, Descovy, Genvoya, Odefsey, Stribild, Symfi, or Truvada). Tell your doctor if you have ever had: liver disease (especially hepatitis B if you also have HIV); HIV (if you are taking tenofovir to treat hepatitis B); kidney disease; or low bone mineral density. You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. Ask your doctor about your risk. To prevent HIV in a newborn baby, use all medications to control your infection during pregnancy. Your name may be listed on an antiviral pregnancy registry. Women with HIV should not breastfeed. The virus can pass to your baby in your breast milk. How should I take tenofovir? Before you start treatment with tenofovir, your doctor may perform tests to make sure you do not have HIV (if you are being treated for hepatitis B) or hepatitis B (if you are being treated for HIV). Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. Take tenofovir at the same time each day. Some forms of tenofovir should be taken with food. Carefully follow all instructions on your medicine label. Tenofovir oral powder should be mixed with soft food such as applesauce, yogurt, or baby food. Do not mix the oral powder with liquid. Swallow the tablet whole and do not crush, chew, or break it. Tell your doctor if you or your the child taking tenofovir has trouble swallowing a tablet. Doses are based on weight in children. Your child's dose needs may change if the child gains or loses weight. You will need medical tests. Use all HIV medications as directed. Do not change your dose or stop using a medicine without your doctor's advice. Remain under the care of a doctor. Store tightly closed at room temperature, away from moisture and heat. If you've had hepatitis B, it may come back or get worse after you stop using tenofovir. You may need liver function tests while using this medicine and for several months after you stop.   What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. Get your prescription refilled before you run out of medicine completely. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking tenofovir? Drinking alcohol may increase your risk of liver damage. Using tenofovir will not prevent your disease from spreading. Do not have unprotected sex or share razors or toothbrushes. Ask your doctor how to prevent HIV transmission during sex. Sharing drug or medicine needles is never safe. Tenofovir side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Mild symptoms of lactic acidosis may worsen over time, and this condition can be fatal. Get emergency medical help if you have: unusual muscle pain, trouble breathing, stomach pain, vomiting, fast/slow or irregular heartbeats, dizziness, feeling cold, or feeling very weak or tired. Call your doctor at once if you have: sore throat, flu symptoms, easy bruising or unusual bleeding; kidney problems--little or no urination, painful or difficult urination, swelling in your feet or ankles, feeling tired or short of breath; or liver problems--swelling around your midsection, upper stomach pain, unusual tiredness, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes). Tenofovir can affect your immune system (even weeks or months after you've used this medicine). Tell your doctor if you have: signs of a new infection--fever, night sweats, swollen glands, cold sores, cough, wheezing, diarrhea, weight loss; trouble speaking or swallowing, problems with balance or eye movement, weakness or prickly feeling; or swelling in your neck or throat (enlarged thyroid), menstrual changes, impotence. Common side effects may include: stomach pain, nausea, vomiting, diarrhea; fever, pain; weakness, dizziness; headache; depressed mood; itching, rash; or sleep problems (insomnia). This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect tenofovir? Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective. Tenofovir can harm your kidneys, especially if you also use certain medicines for infections, cancer, osteoporosis, organ transplant rejection, high blood pressure, or pain or arthritis (including Advil, Motrin, and Aleve). Many drugs can affect tenofovir. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all other medicines you use.

What is terazosin? Terazosin is in a group of drugs called alpha-adrenergic blockers. Terazosin relaxes your veins and arteries so that blood can more easily pass through them. It also relaxes the muscles in the prostate and bladder neck, making it easier to urinate. Terazosin is used to treat hypertension (high blood pressure), or to improve urination in men with benign prostatic hyperplasia (enlarged prostate). Terazosin may also be used for other purposes not listed in this medication guide. Warnings Terazosin may cause dizziness or fainting, especially when you first start taking it or when you start taking it again. You may wish to take this medication only at bedtime if it causes you to feel light-headed. Be careful if you drive or do anything that requires you to be alert. Avoid standing for long periods of time or becoming overheated during exercise and in hot weather. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. You should not use this medication if you are allergic to terazosin. If you stop taking terazosin for any reason, call your doctor before you start taking it again. You may need a dose adjustment. Terazosin can affect your pupils during cataract surgery. Tell your eye surgeon ahead of time that you are using terazosin. Do not stop using terazosin before surgery unless your surgeon tells you to. Tell your doctor about all other medications you use, especially other blood pressure medications including diuretics (water pills). Before taking this medicine You should not use this medication if you are allergic to terazosin. If you have a history of prostate cancer, you may need a dose adjustment or special tests to safely take terazosin. Terazosin can affect your pupils during cataract surgery. Tell your eye surgeon ahead of time that you are using this medication. Do not stop using terazosin before surgery unless your surgeon tells you to. FDA pregnancy category C. It is not known whether terazosin will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. It is not known whether terazosin passes into breast milk or if it could harm a nursing baby. Do not use terazosin without telling your doctor if you are breast-feeding a baby. Terazosin pregnancy and breastfeeding warnings (more detail) How should I take terazosin? Take terazosin exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Your doctor may occasionally change your terazosin dose to make sure you get the best results. Terazosin lowers blood pressure and may cause dizziness or fainting, especially when you first start taking it, or when you start taking it again. You may wish to take this medication only at bedtime if it causes you to feel light-headed. Call your doctor if you have severe dizziness or feel like you might pass out. You may feel very dizzy when you first wake up. Be careful when standing or sitting up from a lying position. If you stop taking terazosin for any reason, call your doctor before you start taking it again. You may need a dose adjustment. Your blood pressure or prostate will need to be checked often. Visit your doctor regularly. If you are being treated for high blood pressure, keep using terazosin even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life. Some things can cause your blood pressure to get too low. This includes vomiting, diarrhea, heavy sweating, heart disease, dialysis, a low-salt diet, or taking diuretics (water pills). Tell your doctor if you have a prolonged illness that causes diarrhea or vomiting. Store terazosin at room temperature away from moisture, heat, and light. What happens if I miss a dose? Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. If you miss your doses for several days in a row, contact your doctor before restarting the medication. You may need a lower dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include extreme dizziness or fainting. What should I avoid? Terazosin may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. To prevent dizziness, avoid standing for long periods of time or becoming overheated during exercise and in hot weather. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall. Drinking alcohol can increase certain side effects of terazosin. Terazosin side effects Get emergency medical help if you have any of these signs of an allergic reaction to terazosin: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects: fast or pounding heartbeats or fluttering in your chest; feeling like you might pass out; swelling in your hands, ankles, or feet; or penis erection that is painful or lasts 4 hours or longer. Less serious terazosin side effects may include: mild dizziness; weakness, drowsiness; blurred vision; nausea; or headache. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Terazosin side effects (more detail) Dosing information Usual Adult Dose for Hypertension: Initial dose: 1 mg orally once a day at bedtime Maintenance dose: 1-5 mg orally once a day. Maximum dose: 20 mg per day. Usual Adult Dose for Benign Prostatic Hyperplasia: Initial dose: 1 mg orally once a day at bedtime. Maintenance dose: Increased in a stepwise fashion to 2 mg, 5 mg, or 10 mg once a day to achieve desired improvement of symptoms. Detailed Terazosin dosage information What other drugs will affect terazosin? Tell your doctor about all other medications you use, especially: sildenafil (Viagra, Revatio); tadalafil (Cialis); vardenafil (Levitra); verapamil (Calan, Covera, Isoptin, Verelan); or other blood pressure medications, including diuretics (water pills). This list is not complete and other drugs may interact with terazosin. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

What is testosterone? Testosterone is a naturally occurring sex hormone that is produced in a man's testicles. Small amounts of testosterone are also produced in a woman's ovaries and adrenal system. Testosterone injection is used in men and boys to treat conditions caused by a lack of this hormone, such as delayed puberty or growth. It is only recommended for males with a known medical condition, such as a genetic disorder, problem with certain brain structures (called the hypothalamus and pituitary) or previous chemotherapy. Testosterone injection is also used in women to treat certain types of breast cancer that have spread to other parts of the body. Testosterone should not be used to enhance athletic performance or to treat normal male aging. Testosterone injection is also used "off-label" for the treatment of gender dysphoria. Injections are typically administered weekly by the user in a home setting. Warnings Do not use this medicine if you are pregnant or may become pregnant. You should not receive testosterone if you have prostate cancer, male breast cancer, a serious heart condition, or severe liver or kidney disease. Misuse of testosterone can cause dangerous or irreversible effects. Testosterone injections should be given only by a healthcare professional. Testosterone can lead to serious problems with the heart, brain, liver, endocrine, and mental health systems. Stopping testosterone may also lead to unpleasant withdrawal symptoms. Testosterone injections have also been linked to a condition called pulmonary oil microembolism (POME), or a blood clot in the lung that can be fatal. Seek medical help immediately for symptoms including chest pain, dizziness, trouble breathing, urge to cough, throat tightening and fainting. Before taking this medicine You should not receive testosterone if you are allergic to it, or if you have: prostate cancer; male breast cancer; a serious heart condition; severe liver disease; severe kidney disease; or if you are pregnant or may become pregnant. To make sure testosterone is safe for you, tell your doctor if you have: heart disease or coronary artery disease; a history of heart attack, stroke, or blood clot; diabetes; enlarged prostate; high cholesterol or triglycerides (a type of fat in the blood); breast cancer (in men, or in women who have hypercalcemia); liver or kidney disease; high calcium levels; if you are bedridden or otherwise debilitated; or if you take a blood thinner (warfarin, Coumadin, Jantoven). This medicine can harm an unborn baby. Do not use testosterone if you are pregnant or may become pregnant. Tell your doctor right away if you become pregnant during treatment. Use effective birth control while you are receiving this medicine. It is not known whether testosterone passes into breast milk or if it could harm a nursing baby. You should not breastfeed while using this medicine. How is testosterone injection given? Testosterone is injected into a muscle. The injection is usually given every 2 to 4 weeks. Testosterone injections should be given only by a healthcare professional. Misuse can lead to serious side effects or death. The length of treatment will depend on the condition being treated. Testosterone will not enhance athletic performance and should not be used for that purpose. While receiving this medicine, you will need frequent blood tests. Testosterone can affect bone growth in boys who are treated for delayed puberty. Bone development may need to be checked with x-rays every 6 months during treatment.   What happens if I miss a dose? Call your doctor for instructions if you miss an appointment for your testosterone injection. What happens if I overdose? Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur. What should I avoid while receiving testosterone injection? Follow your doctor's instructions about any restrictions on food, beverages, or activity. Testosterone side effects Get emergency medical help if you have any signs of an allergic reaction to testosterone: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Get emergency medical help if you have any signs of a blood clot in the lung after using testosterone. These symptoms include chest pain, dizziness, trouble breathing, urge to cough, throat tightening and fainting. Misuse of testosterone can cause dangerous or irreversible effects, such as enlarged breasts, small testicles, infertility, high blood pressure, heart attack, stroke, liver disease, bone growth problems, addiction, and mental effects such as aggression and violence. Call your doctor at once if you have: chest pain or pressure, pain spreading to your jaw or shoulder; swelling in your ankles or feet, rapid weight gain; chest pain, sudden cough, wheezing, rapid breathing, coughing up blood; pain, swelling, warmth, or redness in one or both legs; nausea or vomiting; changes in skin color; increased or ongoing erection of the penis; impotence, ejaculation problems, decreased amounts of semen, decrease in testicle size; painful or difficult urination; shortness of breath (even with mild exertion); stomach pain, constipation, increased thirst or urination, muscle pain or weakness, joint pain, confusion, and feeling tired or restless; or upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes). Women receiving testosterone may develop male characteristics, which could be irreversible if treatment is continued. Call your doctor at once if you notice any of these signs of excess testosterone: acne; changes in menstrual periods; male-pattern hair growth (such as on the chin or chest); hoarse or deepened voice; or enlarged clitoris. Common testosterone side effects (in men or women) may include: breast swelling; headache, anxiety; increased facial or body hair growth, male-pattern baldness; increased or decreased interest in sex; numbness or tingly feeling; or pain or swelling where the medicine was injected. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect testosterone? Certain drugs may interact with testosterone, including; Blood thinners (including warfarin, Coumadin, Jantoven) Anti-inflammatory drugs, such as oxyphenbutazone Other prescription and over-the-counter medicines, vitamins, and herbal products may also react with testosterone. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

What is testosterone? Testosterone is a naturally occurring sex hormone that is produced in a man's testicles. Small amounts of testosterone are also produced in a woman's ovaries and adrenal system. Testosterone injection is used in men and boys to treat conditions caused by a lack of this hormone, such as delayed puberty or growth. It is only recommended for males with a known medical condition, such as a genetic disorder, problem with certain brain structures (called the hypothalamus and pituitary) or previous chemotherapy. Testosterone injection is also used in women to treat certain types of breast cancer that have spread to other parts of the body. Testosterone should not be used to enhance athletic performance or to treat normal male aging. Testosterone injection is also used "off-label" for the treatment of gender dysphoria. Injections are typically administered weekly by the user in a home setting. Warnings Do not use this medicine if you are pregnant or may become pregnant. You should not receive testosterone if you have prostate cancer, male breast cancer, a serious heart condition, or severe liver or kidney disease. Misuse of testosterone can cause dangerous or irreversible effects. Testosterone injections should be given only by a healthcare professional. Testosterone can lead to serious problems with the heart, brain, liver, endocrine, and mental health systems. Stopping testosterone may also lead to unpleasant withdrawal symptoms. Testosterone injections have also been linked to a condition called pulmonary oil microembolism (POME), or a blood clot in the lung that can be fatal. Seek medical help immediately for symptoms including chest pain, dizziness, trouble breathing, urge to cough, throat tightening and fainting. Before taking this medicine You should not receive testosterone if you are allergic to it, or if you have: prostate cancer; male breast cancer; a serious heart condition; severe liver disease; severe kidney disease; or if you are pregnant or may become pregnant. To make sure testosterone is safe for you, tell your doctor if you have: heart disease or coronary artery disease; a history of heart attack, stroke, or blood clot; diabetes; enlarged prostate; high cholesterol or triglycerides (a type of fat in the blood); breast cancer (in men, or in women who have hypercalcemia); liver or kidney disease; high calcium levels; if you are bedridden or otherwise debilitated; or if you take a blood thinner (warfarin, Coumadin, Jantoven). This medicine can harm an unborn baby. Do not use testosterone if you are pregnant or may become pregnant. Tell your doctor right away if you become pregnant during treatment. Use effective birth control while you are receiving this medicine. It is not known whether testosterone passes into breast milk or if it could harm a nursing baby. You should not breastfeed while using this medicine. How is testosterone injection given? Testosterone is injected into a muscle. The injection is usually given every 2 to 4 weeks. Testosterone injections should be given only by a healthcare professional. Misuse can lead to serious side effects or death. The length of treatment will depend on the condition being treated. Testosterone will not enhance athletic performance and should not be used for that purpose. While receiving this medicine, you will need frequent blood tests. Testosterone can affect bone growth in boys who are treated for delayed puberty. Bone development may need to be checked with x-rays every 6 months during treatment.   What happens if I miss a dose? Call your doctor for instructions if you miss an appointment for your testosterone injection. What happens if I overdose? Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur. What should I avoid while receiving testosterone injection? Follow your doctor's instructions about any restrictions on food, beverages, or activity. Testosterone side effects Get emergency medical help if you have any signs of an allergic reaction to testosterone: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Get emergency medical help if you have any signs of a blood clot in the lung after using testosterone. These symptoms include chest pain, dizziness, trouble breathing, urge to cough, throat tightening and fainting. Misuse of testosterone can cause dangerous or irreversible effects, such as enlarged breasts, small testicles, infertility, high blood pressure, heart attack, stroke, liver disease, bone growth problems, addiction, and mental effects such as aggression and violence. Call your doctor at once if you have: chest pain or pressure, pain spreading to your jaw or shoulder; swelling in your ankles or feet, rapid weight gain; chest pain, sudden cough, wheezing, rapid breathing, coughing up blood; pain, swelling, warmth, or redness in one or both legs; nausea or vomiting; changes in skin color; increased or ongoing erection of the penis; impotence, ejaculation problems, decreased amounts of semen, decrease in testicle size; painful or difficult urination; shortness of breath (even with mild exertion); stomach pain, constipation, increased thirst or urination, muscle pain or weakness, joint pain, confusion, and feeling tired or restless; or upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes). Women receiving testosterone may develop male characteristics, which could be irreversible if treatment is continued. Call your doctor at once if you notice any of these signs of excess testosterone: acne; changes in menstrual periods; male-pattern hair growth (such as on the chin or chest); hoarse or deepened voice; or enlarged clitoris. Common testosterone side effects (in men or women) may include: breast swelling; headache, anxiety; increased facial or body hair growth, male-pattern baldness; increased or decreased interest in sex; numbness or tingly feeling; or pain or swelling where the medicine was injected. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect testosterone? Certain drugs may interact with testosterone, including; Blood thinners (including warfarin, Coumadin, Jantoven) Anti-inflammatory drugs, such as oxyphenbutazone Other prescription and over-the-counter medicines, vitamins, and herbal products may also react with testosterone. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

What is testosterone? Testosterone is a naturally occurring sex hormone that is produced in a man's testicles. Small amounts of testosterone are also produced in a woman's ovaries and adrenal system. Testosterone injection is used in men and boys to treat conditions caused by a lack of this hormone, such as delayed puberty or growth. It is only recommended for males with a known medical condition, such as a genetic disorder, problem with certain brain structures (called the hypothalamus and pituitary) or previous chemotherapy. Testosterone injection is also used in women to treat certain types of breast cancer that have spread to other parts of the body. Testosterone should not be used to enhance athletic performance or to treat normal male aging. Testosterone injection is also used "off-label" for the treatment of gender dysphoria. Injections are typically administered weekly by the user in a home setting. Warnings Do not use this medicine if you are pregnant or may become pregnant. You should not receive testosterone if you have prostate cancer, male breast cancer, a serious heart condition, or severe liver or kidney disease. Misuse of testosterone can cause dangerous or irreversible effects. Testosterone injections should be given only by a healthcare professional. Testosterone can lead to serious problems with the heart, brain, liver, endocrine, and mental health systems. Stopping testosterone may also lead to unpleasant withdrawal symptoms. Testosterone injections have also been linked to a condition called pulmonary oil microembolism (POME), or a blood clot in the lung that can be fatal. Seek medical help immediately for symptoms including chest pain, dizziness, trouble breathing, urge to cough, throat tightening and fainting. Before taking this medicine You should not receive testosterone if you are allergic to it, or if you have: prostate cancer; male breast cancer; a serious heart condition; severe liver disease; severe kidney disease; or if you are pregnant or may become pregnant. To make sure testosterone is safe for you, tell your doctor if you have: heart disease or coronary artery disease; a history of heart attack, stroke, or blood clot; diabetes; enlarged prostate; high cholesterol or triglycerides (a type of fat in the blood); breast cancer (in men, or in women who have hypercalcemia); liver or kidney disease; high calcium levels; if you are bedridden or otherwise debilitated; or if you take a blood thinner (warfarin, Coumadin, Jantoven). This medicine can harm an unborn baby. Do not use testosterone if you are pregnant or may become pregnant. Tell your doctor right away if you become pregnant during treatment. Use effective birth control while you are receiving this medicine. It is not known whether testosterone passes into breast milk or if it could harm a nursing baby. You should not breastfeed while using this medicine. How is testosterone injection given? Testosterone is injected into a muscle. The injection is usually given every 2 to 4 weeks. Testosterone injections should be given only by a healthcare professional. Misuse can lead to serious side effects or death. The length of treatment will depend on the condition being treated. Testosterone will not enhance athletic performance and should not be used for that purpose. While receiving this medicine, you will need frequent blood tests. Testosterone can affect bone growth in boys who are treated for delayed puberty. Bone development may need to be checked with x-rays every 6 months during treatment.   What happens if I miss a dose? Call your doctor for instructions if you miss an appointment for your testosterone injection. What happens if I overdose? Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur. What should I avoid while receiving testosterone injection? Follow your doctor's instructions about any restrictions on food, beverages, or activity. Testosterone side effects Get emergency medical help if you have any signs of an allergic reaction to testosterone: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Get emergency medical help if you have any signs of a blood clot in the lung after using testosterone. These symptoms include chest pain, dizziness, trouble breathing, urge to cough, throat tightening and fainting. Misuse of testosterone can cause dangerous or irreversible effects, such as enlarged breasts, small testicles, infertility, high blood pressure, heart attack, stroke, liver disease, bone growth problems, addiction, and mental effects such as aggression and violence. Call your doctor at once if you have: chest pain or pressure, pain spreading to your jaw or shoulder; swelling in your ankles or feet, rapid weight gain; chest pain, sudden cough, wheezing, rapid breathing, coughing up blood; pain, swelling, warmth, or redness in one or both legs; nausea or vomiting; changes in skin color; increased or ongoing erection of the penis; impotence, ejaculation problems, decreased amounts of semen, decrease in testicle size; painful or difficult urination; shortness of breath (even with mild exertion); stomach pain, constipation, increased thirst or urination, muscle pain or weakness, joint pain, confusion, and feeling tired or restless; or upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes). Women receiving testosterone may develop male characteristics, which could be irreversible if treatment is continued. Call your doctor at once if you notice any of these signs of excess testosterone: acne; changes in menstrual periods; male-pattern hair growth (such as on the chin or chest); hoarse or deepened voice; or enlarged clitoris. Common testosterone side effects (in men or women) may include: breast swelling; headache, anxiety; increased facial or body hair growth, male-pattern baldness; increased or decreased interest in sex; numbness or tingly feeling; or pain or swelling where the medicine was injected. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect testosterone? Certain drugs may interact with testosterone, including; Blood thinners (including warfarin, Coumadin, Jantoven) Anti-inflammatory drugs, such as oxyphenbutazone Other prescription and over-the-counter medicines, vitamins, and herbal products may also react with testosterone. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

What is testosterone? Testosterone is a naturally occurring sex hormone that is produced in a man's testicles. Small amounts of testosterone are also produced in a woman's ovaries and adrenal system. Testosterone injection is used in men and boys to treat conditions caused by a lack of this hormone, such as delayed puberty or growth. It is only recommended for males with a known medical condition, such as a genetic disorder, problem with certain brain structures (called the hypothalamus and pituitary) or previous chemotherapy. Testosterone injection is also used in women to treat certain types of breast cancer that have spread to other parts of the body. Testosterone should not be used to enhance athletic performance or to treat normal male aging. Testosterone injection is also used "off-label" for the treatment of gender dysphoria. Injections are typically administered weekly by the user in a home setting. Warnings Do not use this medicine if you are pregnant or may become pregnant. You should not receive testosterone if you have prostate cancer, male breast cancer, a serious heart condition, or severe liver or kidney disease. Misuse of testosterone can cause dangerous or irreversible effects. Testosterone injections should be given only by a healthcare professional. Testosterone can lead to serious problems with the heart, brain, liver, endocrine, and mental health systems. Stopping testosterone may also lead to unpleasant withdrawal symptoms. Testosterone injections have also been linked to a condition called pulmonary oil microembolism (POME), or a blood clot in the lung that can be fatal. Seek medical help immediately for symptoms including chest pain, dizziness, trouble breathing, urge to cough, throat tightening and fainting. Before taking this medicine You should not receive testosterone if you are allergic to it, or if you have: prostate cancer; male breast cancer; a serious heart condition; severe liver disease; severe kidney disease; or if you are pregnant or may become pregnant. To make sure testosterone is safe for you, tell your doctor if you have: heart disease or coronary artery disease; a history of heart attack, stroke, or blood clot; diabetes; enlarged prostate; high cholesterol or triglycerides (a type of fat in the blood); breast cancer (in men, or in women who have hypercalcemia); liver or kidney disease; high calcium levels; if you are bedridden or otherwise debilitated; or if you take a blood thinner (warfarin, Coumadin, Jantoven). This medicine can harm an unborn baby. Do not use testosterone if you are pregnant or may become pregnant. Tell your doctor right away if you become pregnant during treatment. Use effective birth control while you are receiving this medicine. It is not known whether testosterone passes into breast milk or if it could harm a nursing baby. You should not breastfeed while using this medicine. How is testosterone injection given? Testosterone is injected into a muscle. The injection is usually given every 2 to 4 weeks. Testosterone injections should be given only by a healthcare professional. Misuse can lead to serious side effects or death. The length of treatment will depend on the condition being treated. Testosterone will not enhance athletic performance and should not be used for that purpose. While receiving this medicine, you will need frequent blood tests. Testosterone can affect bone growth in boys who are treated for delayed puberty. Bone development may need to be checked with x-rays every 6 months during treatment.   What happens if I miss a dose? Call your doctor for instructions if you miss an appointment for your testosterone injection. What happens if I overdose? Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur. What should I avoid while receiving testosterone injection? Follow your doctor's instructions about any restrictions on food, beverages, or activity. Testosterone side effects Get emergency medical help if you have any signs of an allergic reaction to testosterone: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Get emergency medical help if you have any signs of a blood clot in the lung after using testosterone. These symptoms include chest pain, dizziness, trouble breathing, urge to cough, throat tightening and fainting. Misuse of testosterone can cause dangerous or irreversible effects, such as enlarged breasts, small testicles, infertility, high blood pressure, heart attack, stroke, liver disease, bone growth problems, addiction, and mental effects such as aggression and violence. Call your doctor at once if you have: chest pain or pressure, pain spreading to your jaw or shoulder; swelling in your ankles or feet, rapid weight gain; chest pain, sudden cough, wheezing, rapid breathing, coughing up blood; pain, swelling, warmth, or redness in one or both legs; nausea or vomiting; changes in skin color; increased or ongoing erection of the penis; impotence, ejaculation problems, decreased amounts of semen, decrease in testicle size; painful or difficult urination; shortness of breath (even with mild exertion); stomach pain, constipation, increased thirst or urination, muscle pain or weakness, joint pain, confusion, and feeling tired or restless; or upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes). Women receiving testosterone may develop male characteristics, which could be irreversible if treatment is continued. Call your doctor at once if you notice any of these signs of excess testosterone: acne; changes in menstrual periods; male-pattern hair growth (such as on the chin or chest); hoarse or deepened voice; or enlarged clitoris. Common testosterone side effects (in men or women) may include: breast swelling; headache, anxiety; increased facial or body hair growth, male-pattern baldness; increased or decreased interest in sex; numbness or tingly feeling; or pain or swelling where the medicine was injected. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect testosterone? Certain drugs may interact with testosterone, including; Blood thinners (including warfarin, Coumadin, Jantoven) Anti-inflammatory drugs, such as oxyphenbutazone Other prescription and over-the-counter medicines, vitamins, and herbal products may also react with testosterone. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.