What is olanzapine? Olanzapine is an antipsychotic medication that is used to treat psychotic conditions such as schizophrenia and bipolar disorder (manic depression) in adults and children at least 13 years old. Olanzapine is also used together with fluoxetine (Prozac) to treat episodes of depression in adults and children at least 10 years old who have bipolar I disorder. Olanzapine may also be used for purposes not listed in this medication guide. Warnings Olanzapine is not approved for use in older adults with dementia-related psychosis. Before taking this medicine You should not take olanzapine if you are allergic to it. Olanzapine may increase the risk of death in older adults with dementia-related psychosis and is not approved for this use. Tell your doctor if you have ever had: liver disease; heart disease, high or low blood pressure; high cholesterol or triglycerides; a stroke, including "mini-stroke"; breast cancer; a seizure; Alzheimer's disease; diabetes or high blood sugar; an enlarged prostate; bowel problems; or narrow-angle glaucoma. Taking antipsychotic medicine in the last 3 months of pregnancy may cause breathing problems, feeding problems, or withdrawal symptoms in the newborn. If you get pregnant, tell your doctor right away. Do not stop taking olanzapine without your doctor's advice. Olanzapine can pass into breast milk. If you are breastfeeding, tell your doctor if you notice severe drowsiness, irritability, feeding problems, tremors, or unusual muscle movements in the nursing baby. The olanzapine orally disintegrating tablet (Zyprexa Zydis) may contain phenylalanine. Tell your doctor if you have phenylketonuria (PKU). How should I take olanzapine? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Olanzapine can be taken with or without food. Remove an orally disintegrating tablet (Zyprexa Zydis) from the package only when you are ready to take the medicine. Place the tablet in your mouth and allow it to dissolve, without chewing. Swallow several times as the tablet dissolves. Olanzapine can cause high blood sugar (hyperglycemia). If you are diabetic, check your blood sugar levels on a regular basis. You may gain weight or have high cholesterol and triglycerides (types of fat) while taking olanzapine, especially if you are a teenager. You may need frequent blood tests. Call your doctor if your symptoms do not improve, or if they get worse while using olanzapine. Do not stop using olanzapine suddenly, even if you feel fine. Stopping suddenly may cause serious side effects. Olanzapine is sometimes used together with other antipsychotic medications or antidepressants. Use all medications as directed and read all medication guides you receive. Do not change your dose or dosing schedule without your doctor's advice. Medication may be only part of a complete program of treatment that also includes counseling and other psychological support programs. Follow your doctor's instructions. Store at room temperature away from moisture, heat, and light.   What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include drowsiness, agitation, aggression, slurred speech, confusion, increased heart rate, jerky or uncontrolled muscle movements, trouble breathing, or fainting. What should I avoid while taking olanzapine? Avoid driving or hazardous activity until you know how olanzapine will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Avoid drinking alcohol. Dangerous side effects could occur. Avoid becoming overheated or dehydrated. Drink plenty of fluids, especially in hot weather and during exercise. It is easier to become dangerously overheated and dehydrated while you are taking olanzapine. Olanzapine side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes. High doses or long-term use of olanzapine can cause a serious movement disorder that may not be reversible. The longer you use olanzapine, the more likely you are to develop this disorder, especially if you are a woman or an older adult. Call your doctor at once if you have: uncontrolled muscle movements in your face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement); trouble speaking or swallowing; swelling in your hands or feet; confusion, unusual thoughts or behavior, hallucinations, or thoughts about hurting yourself; low white blood cell counts--fever, chills, mouth sores, skin sores, sore throat, cough, trouble breathing, feeling light-headed; or signs of dehydration--feeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin; liver problems--upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); high blood sugar--increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, weight loss; or severe nervous system reaction--very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out. Common side effects may include: weight gain (more likely in teenagers), increased appetite; headache, dizziness, drowsiness, feeling tired or restless; problems with speech or memory; tremors or shaking, numbness or tingly feeling; changes in personality; dry mouth, or increased salivation; stomach pain, constipation; or pain in your arms or legs. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.  

What is olmesartan? Olmesartan is an angiotensin II receptor blocker (sometimes called an ARB). Olmesartan is used to treat high blood pressure (hypertension) in adults and children at least 6 years old. It is sometimes given together with other blood pressure medications. Olmesartan may also be used for purposes not listed in this medication guide. Warnings Do not use if you are pregnant. Stop using olmesartan and tell your doctor right away if you become pregnant. If you have diabetes, do not take olmesartan with any medication that contains aliskiren (a blood pressure medicine). Before taking this medicine You should not take olmesartan if you are allergic to it. If you have diabetes, do not use olmesartan together with any medication that contains aliskiren (a blood pressure medicine). You may also need to avoid taking olmesartan with aliskiren if you have kidney disease. Tell your doctor if you have ever had: a heart condition other than one being treated with olmesartan; kidney disease; or if you are on a low salt diet. Do not use if you are pregnant. Stop using the medicine and tell your doctor right away if you become pregnant. Olmesartan can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. If you plan to get pregnant, ask your doctor for a safer medicine to use before and during pregnancy. Having high blood pressure during pregnancy may cause complications in the mother and the baby. You should not breastfeed while using olmesartan. How should I take olmesartan? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. You may take olmesartan with or without food. For a child who cannot swallow a tablet whole, a pharmacist can mix the medicine into a liquid. Shake the liquid before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon). Olmesartan doses are based on weight in children and/or teenagers. Your child's dose needs may change if the child gains or loses weight. Call your doctor if you are sick with vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking olmesartan. It may take up to 2 weeks before your blood pressure is under control. Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life. Treatment may also include diet, exercise, lowering cholesterol, not smoking, and controlling diabetes. Your blood pressure will need to be checked often. Your kidney function may also need to be checked. Store tablets at room temperature away from moisture and heat. Store the liquid in a refrigerator. Throw away any liquid leftover after 4 weeks. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include fast heartbeats or fainting. What should I avoid while taking olmesartan? Do not use potassium supplements or salt substitutes, unless your doctor has told you to. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Olmesartan side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: a light-headed feeling, like you might pass out; little or no urination; severe diarrhea and weight loss; or high potassium level--nausea, weakness, tingly feeling, chest pain, irregular heartbeats, loss of movement. Common side effects may include: dizziness. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Olmesartan dosing information Usual Adult Dose for Hypertension: 20 mg orally once a day; may increase dose to 40 mg in two weeks if further blood pressure reduction is needed. Maximum dose: 40 mg orally once a day Comments: -For patients with possible intravascular volume depletion (e.g., patients treated with diuretics, especially those with impaired renal function), initiate this drug under close supervision and give consideration to a lower starting dose. -Twice daily dosing offers no additional benefit over the same total dose give once daily. Usual Pediatric Dose for Hypertension: 6 to 16 years: -20 to less than 35 kg: 10 mg orally once a day; may increase dose to 20 mg in two weeks if further blood pressure reduction is needed -35 kg or more: 20 mg orally once a day; may increase dose to 40 mg in two weeks if further blood pressure reduction is needed Comments: -For children who cannot swallow tablets, the same dose can be given using an extemporaneous suspension.   What other drugs will affect olmesartan? If you take colesevelam, take your olmesartan dose 4 hours before you take colesevelam. Tell your doctor about all your other medicines, especially: lithium; a diuretic (water pill) or other medicines that lower blood pressure; or NSAIDs (nonsteroidal anti-inflammatory drugs)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others. This list is not complete. Other drugs may affect olmesartan, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is hydrochlorothiazide and olmesartan? Hydrochlorothiazide is a diuretic (water pill). Olmesartan is an angiotensin II receptor blocker (sometimes called an ARB blocker). Hydrochlorothiazide and olmesartan is a combination medicine used to treat high blood pressure (hypertension). Lowering blood pressure may lower your risk of a stroke or heart attack. Hydrochlorothiazide and olmesartan is usually given after other blood pressure medicines did not work or have stopped working. Hydrochlorothiazide and olmesartan may also be used for purposes not listed in this medication guide. Warnings You should not use hydrochlorothiazide and olmesartan if you are unable to urinate. Do not use if you are pregnant. Use effective birth control, and tell your doctor if you become pregnant during treatment. If you have diabetes, do not use hydrochlorothiazide and olmesartan together with any medication that contains aliskiren (a blood pressure medicine). Before taking this medicine You should not use this medicine if you are allergic to hydrochlorothiazide or olmesartan, or if you are unable to urinate. If you have diabetes, do not use hydrochlorothiazide and olmesartan together with any medication that contains aliskiren (a blood pressure medicine). You may also need to avoid taking hydrochlorothiazide and olmesartan with aliskiren if you have kidney disease. Tell your doctor if you have ever had: kidney disease; liver disease; congestive heart failure; glaucoma; low or high levels of potassium in your blood; asthma or allergies; high cholesterol or triglyceride levels; gout; lupus; diabetes; or an allergy to penicillin or sulfa drugs. Do not use if you are pregnant. Stop using the medicine and tell your doctor right away if you become pregnant. Olmesartan can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. You should not breastfeed while using this medicine. How should I take hydrochlorothiazide and olmesartan? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Your blood pressure will need to be checked often. Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking this medication, which can lead to severely low blood pressure or a serious electrolyte imbalance. If you need surgery or medical tests, tell the surgeon ahead of time that you are using hydrochlorothiazide and olmesartan. It may take up to 4 weeks for this medication to control your blood pressure. Keep using hydrochlorothiazide and olmesartan as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life. Store at room temperature away from moisture and heat. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include fast or slow heart rate, feeling light-headed, or fainting. What should I avoid while taking hydrochlorothiazide and olmesartan? Hydrochlorothiazide may increase your risk of skin cancer. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors. Your doctor may want you to have skin examinations on a regular basis. Do not use potassium supplements or salt substitutes, unless your doctor has told you to. Drinking alcohol can further lower your blood pressure and may cause side effects. Avoid driving or hazardous activity until you know how hydrochlorothiazide and olmesartan will affect you. Your reactions could be impaired. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Hydrochlorothiazide and olmesartan side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. In rare cases, this medicine can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, or dark colored urine. Also call your doctor at once if you have: a light-headed feeling, like you might pass out; eye pain, vision problems; an unusual skin rash; easy bruising, unusual bleeding; jaundice (yellowing of the skin or eyes); kidney problems--little or no urination, painful or difficult urination, swelling in your feet or ankles, feeling tired or short of breath; low levels of sodium in the body--headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady; high potassium--slow or unusual heart rate, weakness, loss of movement; or low potassium--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling. Common side effects include: nausea; dizziness; cold symptoms such as stuffy nose, sneezing, sore throat; or high levels of uric acid in your blood. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Hydrochlorothiazide and olmesartan dosing information Usual Adult Dose for Hypertension: Hydrochlorothiazide 12.5 to 25 mg-Olmesartan 20 to 40 mg orally once a day Comments: -If blood pressure is not controlled by olmesartan alone, hydrochlorothiazide may be added starting with a dose of 12.5 mg once a day; if blood pressure is not controlled by hydrochlorothiazide alone, olmesartan may be added starting with a dose of 20 mg once a day. -If large doses of hydrochlorothiazide have been used as monotherapy and volume depletion or hyponatremia is present, use caution when adding olmesartan as marked decreases in blood pressure may occur. Consider reducing the dose of hydrochlorothiazide to 12.5 mg before adding olmesartan. -May be titrated every 2 to 4 weeks.   What other drugs will affect hydrochlorothiazide and olmesartan? If you also take cholestyramine or colestipol, take your hydrochlorothiazide and olmesartan dose 4 hours before or 4 hours after you take the other medicine. Tell your doctor about all your other medicines, especially: steroids; any other blood pressure medications; insulin or oral diabetes medicine; lithium; or NSAIDs (nonsteroidal anti-inflammatory drugs)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others. This list is not complete. Other drugs may affect hydrochlorothiazide and olmesartan, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is olopatadine ophthalmic? Olopatadine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of itching or watery eyes. Olopatadine ophthalmic (for the eye) is used to treat eye itching caused by allergies. Olopatadine ophthalmic may also be used for purposes not listed in this medication guide. Warnings Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use. Before taking this medicine You should not use olopatadine ophthalmic if you are allergic to it. Ask a doctor or pharmacist if olopatadine ophthalmic is safe to use if you have any type of eye infection. Tell your doctor if you are pregnant or breastfeeding. Olopatadine ophthalmic is not approved for use by anyone younger than 2 years old. How should I use olopatadine ophthalmic? Use exactly as directed on the label, or as prescribed by your doctor. Do not use while wearing soft contact lenses. A preservative in this medicine could permanently stain the lenses. Use the medicine at least 15 minutes before inserting your contact lenses. Wash your hands before using eye medication. To apply the eye drops: Tilt your head back slightly and pull down your lower eyelid to create a small pocket. Hold the dropper above the eye and squeeze a drop into this pocket. Close your eyes for 1 or 2 minutes. Wait at least 10 minutes before using any other eye drops your doctor has prescribed. Use only the number of drops recommended on the medicine label. Do not touch the tip of the eye dropper or place it directly on your eye. A contaminated dropper can infect your eye, which could lead to serious vision problems. Do not use the eye drops if the liquid looks cloudy or has changed colors. Store at room temperature away from moisture and heat. Do not freeze. Keep the bottle tightly closed when not in use. What happens if I miss a dose? Use the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time. What happens if I overdose? An overdose of olopatadine ophthalmic is not expected to be dangerous. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medication. What should I avoid while using olopatadine ophthalmic? Avoid wearing contact lenses while your eyes are red or irritated. olopatadine ophthalmic will not treat eye irritation caused by wearing contacts. Olopatadine ophthalmic side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using this medicine and call your doctor at once if you have: eye pain or changes in vision; eye itching that gets worse or lasts longer than 72 hours; severe burning, stinging, or irritation after using this medicine; or eye swelling, redness, severe discomfort, crusting or drainage (may be signs of infection). Less serious side effects may be more likely, and you may have none at all. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Olopatadine ophthalmic dosing information Usual Adult Dose for Seasonal Allergic Conjunctivitis: 0.1% solution: 1 drop in each affected eye twice per day at an interval of 6 to 8 hours 0.2%/0.7% solution: 1 drop in each affected eye once a day Use: Treatment of the signs and symptoms of allergic conjunctivitis Usual Pediatric Dose for Seasonal Allergic Conjunctivitis: 2 years or older: 0.2%/0.7% solution: 1 drop in each affected eye once a day 3 years or older: 0.1% solution: 1 drop in each affected eye twice per day at an interval of 6 to 8 hours Use: Treatment of the signs and symptoms of allergic conjunctivitis   What other drugs will affect olopatadine ophthalmic? Medicine used in the eyes is not likely to be affected by other drugs you use. But many drugs can interact with each other. Tell each of your healthcare providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.

What is olopatadine nasal? Olopatadine nasal (for the nose) is used to treat seasonal allergy symptoms such as congestion, sneezing, and runny nose. Olopatadine nasal is for use in adults and children at least 6 years old. Olopatadine nasal may also be used for purposes not listed in this medication guide. Warnings Use only as directed. Tell your doctor if you use other medicines or have other medical conditions or allergies. Before taking this medicine You should not use olopatadine if you are allergic to olopatadine. Tell your doctor if you have other conditions that affect the inside of your nose. Tell your doctor if you are pregnant or breastfeeding. Not approved for use by anyone younger than 6 years old. How should I use olopatadine nasal? Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. Before your first use, shake the nasal spray well and prime it with 5 sprays into the air, until a fine mist appears. Spray away from your face. Prime again with 2 sprays whenever the medicine has not been used in longer than 7 days. Gently blow your nose before using the nasal spray. Carefully follow all Instructions for Use provided with this medicine. Call your doctor if your symptoms do not improve, or if they get worse. Store at room temperature away from moisture and heat. Throw away the bottle after 240 sprays have been used, even if there is still medicine left inside. If used daily, one bottle contains enough medicine for 30 days for an adult dose or 60 days for a child's dose. What happens if I miss a dose? Use the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include feeling agitated or restless and then drowsy. What should I avoid while taking olopatadine nasal? Avoid driving or hazardous activity until you know how olopatadine will affect you. Your reactions could be impaired. Drinking alcohol with this medicine can cause side effects. Avoid getting this medication in your eyes. Olopatadine nasal side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using olopatadine and call your doctor at once if you have: nosebleed; painful sores inside your nose; fever; or pain or burning when you urinate. Common side effects may include: runny or stuffy nose, nosebleeds; cough, throat pain or irritation; a bitter taste in your mouth; drowsiness; headache; fever; rash; or painful urination. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Olopatadine dosing information Usual Adult Dose for Allergic Rhinitis: 2 sprays in each nostril twice a day Use: For the relief of symptoms of seasonal allergic rhinitis Usual Pediatric Dose for Allergic Rhinitis: 6 to 11 years: 1 spray in each nostril twice a day 12 years or older: 2 sprays in each nostril twice a day Use: For the relief of symptoms of seasonal allergic rhinitis   What other drugs will affect olopatadine nasal? Using olopatadine with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures. Other drugs may affect olopatadine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

What is omega-3 polyunsaturated fatty acids? Omega-3 polyunsaturated fatty acids are used together with diet and exercise to help lower triglyceride levels in the blood. It is not known if omega-3 polyunsaturated fatty acids will prevent a heart attack or stroke. Talk to your doctor about your risk factors. Omega-3 polyunsaturated fatty acids may also be used for purposes not listed in this medication guide. Warnings Follow all directions on the label and package. Use exactly as directed. Before taking this medicine You should not use omega-3 polyunsaturated fatty acids if you are allergic to omega-3 polyunsaturated fatty acids or soybeans. Ask a doctor or pharmacist if this medicine is safe to use if you have ever had: an allergy to fish or shellfish; diabetes; liver disease; a heart rhythm disorder; a pancreas disorder; or underactive thyroid. Tell your doctor if you are pregnant or breastfeeding. Not approved for use by anyone younger than 18 years old. How should I take omega-3 polyunsaturated fatty acids? Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. Swallow the capsule whole and do not crush, chew, break, or open it. Take with food. You may need frequent blood tests. You may need to follow a special diet. Follow all instructions of your doctor or dietitian. Learn about the foods you should eat or avoid. Tell your doctor if you have a planned surgery. Store at room temperature away from moisture and heat. Do not freeze. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking omega-3 polyunsaturated fatty acids? Avoid eating foods high in fat or cholesterol, or omega-3 polyunsaturated fatty acids will not be as effective. Avoid drinking alcohol. It can increase triglycerides and may make your condition worse. Omega-3 polyunsaturated fatty acids side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: chest pain; or uneven heartbeats. Common side effects may include: loss of appetite; diarrhea, constipation, upset stomach, belching; back pain; or dry mouth, altered sense of taste. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Omega-3 polyunsaturated fatty acids side effects (more detail) Omega-3 polyunsaturated fatty acids dosing information Usual Adult Dose for Hypertriglyceridemia: 1 gram prescription only products: 4 grams orally daily; may be given as a single dose or 2 divided doses. Comments: -Assess triglyceride levels carefully before starting therapy and identify other possible causes (e.g. diabetes, hypothyroidism, medications) and manage appropriately. -Patients should be on a lipid lowering diet prior to using this medication, and continue the diet during use of this medication. -Capsules should be swallowed whole; do not break, crush, chew or dissolve capsules. -In clinical trials, the medication was administered with meals.   What other drugs will affect omega-3 polyunsaturated fatty acids? Tell your doctor about all your other medicines, especially: a blood thinner--warfarin, Coumadin, Jantoven. This list is not complete. Other drugs may affect omega-3 polyunsaturated fatty acids, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is omeprazole? Omeprazole is a proton pump inhibitor that decreases the amount of acid produced in the stomach. Omeprazole is used to treat symptoms of gastroesophageal reflux disease (GERD) and other conditions caused by excess stomach acid. It is also used to promote healing of erosive esophagitis (damage to your esophagus caused by stomach acid). Omeprazole may also be given together with antibiotics to treat gastric ulcer caused by infection with Helicobacter pylori (H. pylori). Over-the-counter (OTC) omeprazole is used in adults to help control heartburn that occurs 2 or more days per week. The OTC brand must be taken as a course on a regular basis for 14 days in a row. Warnings Omeprazole can cause kidney problems. Tell your doctor if you are urinating less than usual, or if you have blood in your urine. Diarrhea may be a sign of a new infection. Call your doctor if you have diarrhea that is watery or has blood in it. Omeprazole is not to used for the immediate relief of heartburn symptoms. Omeprazole may cause new or worsening symptoms of lupus. Tell your doctor if you have joint pain and a skin rash on your cheeks or arms that worsens in sunlight. You may be more likely to have a broken bone while taking this medicine long term or more than once per day. Before taking this medicine Heartburn can mimic early symptoms of a heart attack. Get emergency medical help if you have chest pain that spreads to your jaw or shoulder and you feel sweaty or light-headed. You should not use omeprazole if you are allergic to it, or if: you are also allergic to medicines like omeprazole, such as esomeprazole, lansoprazole, pantoprazole, rabeprazole, Nexium, Prevacid, Protonix, and others; you had breathing problems, kidney problems, or a severe allergic reaction after taking omeprazole in the past; or you also take HIV medication that contains rilpivirine (such as Complera, Edurant, Odefsey, Juluca). Ask a doctor or pharmacist if this medicine is safe to use if you have: trouble or pain with swallowing; bloody or black stools, vomit that looks like blood or coffee grounds; heartburn that has lasted for over 3 months; frequent chest pain, heartburn with wheezing; unexplained weight loss; nausea or vomiting, stomach pain; liver disease; low levels of magnesium in your blood; or osteoporosis or low bone mineral density (osteopenia). You may be more likely to have a broken bone in your hip, wrist, or spine while taking a proton pump inhibitor long-term or more than once per day. Talk with your doctor about ways to keep your bones healthy. Ask a doctor before using this medicine if you are pregnant or breastfeeding. Do not give this medicine to a child without medical advice. How should I take omeprazole? Take omeprazole exactly as directed on the label, or as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Use Prilosec OTC (over-the-counter) exactly as directed on the label, or as prescribed by your doctor. Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions. Shake the oral suspension (liquid) before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon). If you cannot swallow a capsule whole, open it and sprinkle the medicine into a spoonful of applesauce. Swallow the mixture right away without chewing. Do not save it for later use. You must dissolve omeprazole powder in a small amount of water. This mixture can either be swallowed or given through a nasogastric (NG) feeding tube using a catheter-tipped syringe. Use this medicine for the full prescribed length of time, even if your symptoms quickly improve. OTC omeprazole should be taken for only 14 days in a row. It may take 1 to 4 days before your symptoms improve. Allow at least 4 months to pass before you start a new 14-day course of treatment. Call your doctor if your symptoms do not improve, or if they get worse. Some conditions are treated with a combination of omeprazole and antibiotics. Use all medications as directed. This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using this medicine. Store at room temperature away from moisture and heat.   What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What to avoid Omeprazole can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor before using anti-diarrhea medicine. Omeprazole side effects help if you have signs of an allergic reaction to omeprazole: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using this medicine and call your doctor at once if you have: severe stomach pain, diarrhea that is watery or bloody; new or unusual pain in your wrist, thigh, hip, or back; seizure (convulsions); kidney problems - fever, rash, nausea, loss of appetite, joint pain, urinating less than usual, blood in your urine, weight gain; low magnesium - dizziness, irregular heartbeats, feeling jittery, muscle cramps, muscle spasms, cough or choking feeling; or new or worsening symptoms of lupus - joint pain, and a skin rash on your cheeks or arms that worsens in sunlight. Taking omeprazole long-term may cause you to develop stomach growths called fundic gland polyps. Talk with your doctor about this risk. If you use this medicine for longer than 3 years, you could develop a vitamin B-12 deficiency. Talk to your doctor about how to manage this condition if you develop it. Common omeprazole side effects may include: cold symptoms such as stuffy nose, sneezing, sore throat (especially in children); fever (especially in children); stomach pain, gas; nausea, vomiting, diarrhea; or headache. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect omeprazole? Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective. Tell your doctor about all your current medicines. Many drugs can affect omeprazole, especially: digoxin; clopidogrel; methotrexate; St. John's wort; a diuretic or "water pill"; or an antibiotic - amoxicillin, clarithromycin, rifampin. This list is not complete and many Other drugs may interact with omeprazole. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is ondansetron? Ondansetron blocks the actions of chemicals in the body that can trigger nausea and vomiting. Ondansetron is used to prevent nausea and vomiting that may be caused by surgery, cancer chemotherapy, or radiation treatment. Ondansetron may be used for purposes not listed in this medication guide. Warnings You should not use ondansetron if you are also using apomorphine (Apokyn). You should not use ondansetron if you are allergic to it or to similar medicines such as dolasetron (Anzemet), granisetron (Kytril), or palonosetron (Aloxi). Before taking ondansetron, tell your doctor if you have liver disease, or a personal or family history of Long QT syndrome. Ondansetron orally disintegrating tablets may contain phenylalanine. Tell your doctor if you have phenylketonuria (PKU). Serious side effects of ondansetron include blurred vision or temporary vision loss (lasting from only a few minutes to several hours), slow heart rate, trouble breathing, anxiety, agitation, shivering, feeling like you might pass out, and urinating less than usual or not at all. Stop taking this medicine and call your doctor at once if you have any of these side effects. Ondansetron may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Before taking ondansetron You should not use ondansetron if: you are also using apomorphine (Apokyn); or you are allergic to ondansetron or similar medicines (dolasetron, granisetron, palonosetron). To make sure ondansetron is safe for you, tell your doctor if you have: liver disease; an electrolyte imbalance (such as low levels of potassium or magnesium in your blood); congestive heart failure, slow heartbeats; a personal or family history of long QT syndrome; or a blockage in your digestive tract (stomach or intestines). Ondansetron is not expected to harm an unborn baby. Tell your doctor if you are pregnant. It is not known whether ondansetron passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby. Ondansetron is not approved for use by anyone younger than 4 years old. Ondansetron orally disintegrating tablets may contain phenylalanine. Tell your doctor if you have phenylketonuria (PKU). How should I take ondansetron? Take ondansetron exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. Ondansetron can be taken with or without food. The first dose is usually taken before the start of your surgery, chemotherapy, or radiation treatment. Follow your doctor's dosing instructions very carefully. Take the ondansetron regular tablet with a full glass of water. To take the orally disintegrating tablet (Zofran ODT): Keep the tablet in its blister pack until you are ready to take it. Open the package and peel back the foil. Do not push a tablet through the foil or you may damage the tablet. Use dry hands to remove the tablet and place it in your mouth. Do not swallow the tablet whole. Allow it to dissolve in your mouth without chewing. Swallow several times as the tablet dissolves. To use ondansetron oral soluble film (strip) (Zuplenz): Keep the strip in the foil pouch until you are ready to use the medicine. Using dry hands, remove the strip and place it on your tongue. It will begin to dissolve right away. Do not swallow the strip whole. Allow it to dissolve in your mouth without chewing. Swallow several times after the strip dissolves. If desired, you may drink liquid to help swallow the dissolved strip. Wash your hands after using Zuplenz. Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one. Store at room temperature away from moisture, heat, and light. Store liquid medicine in an upright position. What happens if I miss a dose? Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include sudden loss of vision, severe constipation, feeling light-headed, or fainting. What to avoid Ondansetron may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Ondansetron side effects Get emergency medical help if you have signs of an allergic reaction to ondansetron: rash, hives; fever, chills, difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: severe constipation, stomach pain, or bloating; headache with chest pain and severe dizziness, fainting, fast or pounding heartbeats; fast or pounding heartbeats; jaundice (yellowing of the skin or eyes); blurred vision or temporary vision loss (lasting from only a few minutes to several hours); high levels of serotonin in the body--agitation, hallucinations, fever, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, fainting. Common ondansetron side effects may include: diarrhea or constipation; headache; drowsiness; or tired feeling. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Dosing information Usual Adult Dose of Ondansetron for Nausea/Vomiting -- Chemotherapy Induced: Oral: Highly Emetogenic Cancer Chemotherapy (HEC): -Recommended dose: 24 mg orally 30 minutes before the start of single-day HEC (including cisplatin doses of 50 mg/m2 or greater) Moderately Emetogenic Cancer Chemotherapy (MEC): -Recommended dose: 8 mg orally twice a day, with the first dose administered 30 minutes before the start of chemotherapy and the subsequent dose 8 hours later; then 8 mg orally 2 times a day (every 12 hours) for 1 to 2 days after the completion of chemotherapy Parenteral: -Recommended dose: 0.15 mg/kg IV, with the first dose (infused over 15 minutes) 30 minutes before the start of emetogenic chemotherapy and subsequent doses given 4 and 8 hours after the first dose. -Maximum dose: 16 mg per dose Comments: -Multi-day, single-dose administration of 24 mg orally for HEC has not been studied. -The injection formulation should be diluted prior to IV administration. Uses: -Prevention of nausea and vomiting associated with HEC or MEC -Prevention of nausea and vomiting associated with initial and repeat courses of emetogenic chemotherapy Usual Adult Dose of Ondansetron for Nausea/Vomiting: Oral: Highly Emetogenic Cancer Chemotherapy (HEC): -Recommended dose: 24 mg orally 30 minutes before the start of single-day HEC (including cisplatin doses of 50 mg/m2 or greater) Moderately Emetogenic Cancer Chemotherapy (MEC): -Recommended dose: 8 mg orally twice a day, with the first dose administered 30 minutes before the start of chemotherapy and the subsequent dose 8 hours later; then 8 mg orally 2 times a day (every 12 hours) for 1 to 2 days after the completion of chemotherapy Parenteral: -Recommended dose: 0.15 mg/kg IV, with the first dose (infused over 15 minutes) 30 minutes before the start of emetogenic chemotherapy and subsequent doses given 4 and 8 hours after the first dose. -Maximum dose: 16 mg per dose Comments: -Multi-day, single-dose administration of 24 mg orally for HEC has not been studied. -The injection formulation should be diluted prior to IV administration. Uses: -Prevention of nausea and vomiting associated with HEC or MEC -Prevention of nausea and vomiting associated with initial and repeat courses of emetogenic chemotherapy Usual Adult Dose of Ondansetron for Nausea/Vomiting -- Postoperative: Oral: -Recommended dose: 16 mg orally 1 hour before the induction of anesthesia Parenteral: -Recommended dose: 4 mg IV (undiluted) immediately before induction of anesthesia or postoperatively (nausea and/or vomiting within 2 hours after surgery) -Alternative route: 4 mg IM (undiluted) Comment: -Administration of a second dose does not provide additional control of nausea and vomiting. Use: -Prevention of postoperative nausea and vomiting Usual Adult Dose for Nausea/Vomiting--Radiation Induced: Recommended dose: 8 mg orally 3 times a day -Total Body Irradiation: 8 mg orally 1 to 2 hours before each fraction of radiotherapy administered each day -Single High-dose Fraction Radiotherapy to the Abdomen: 8 mg orally 1 to 2 hours before radiotherapy, with subsequent doses every 8 hours after the first dose for 1 to 2 days after the completion of radiotherapy -Daily Fractionated Radiotherapy to the Abdomen: 8 mg orally 1 to 2 hours before radiotherapy, with subsequent doses every 8 hours after the first dose for each day radiotherapy is given Use: -Prevention of nausea and vomiting associated with radiotherapy, either as total body irradiation, single high-dose fraction, or daily fractions to the abdomen Usual Pediatric Dose for Nausea/Vomiting -- Postoperative: Parenteral: 1 month to 12 years: Less than 40 kg: -Recommended dose: 0.1 mg/kg IV over 2 to 5 minutes immediately prior to/following anesthesia induction or postoperatively (nausea and/or vomiting occurring shortly after surgery) 40 kg and greater: -Recommended dose: 4 mg IV over 2 to 5 minutes immediately prior to/following anesthesia induction or postoperatively (nausea and/or vomiting occurring shortly after surgery) Use: -Prevention of postoperative nausea and vomiting Usual Pediatric Dose for Nausea/Vomiting -- Chemotherapy Induced: Oral: 4 to 11 years: -Recommended dose: 4 mg orally 3 times a day, with the first dose administered 30 minutes before the start of chemotherapy, and subsequent doses 4 and 8 hours after the first dose; then 4 mg orally 3 times a day (every 8 hours) for 1 to 2 days after the completion of chemotherapy 12 years and older: -Recommended dose: 8 mg orally twice a day, with the first dose administered 30 minutes before the start of chemotherapy and the subsequent dose 8 hours later; then 8 mg orally 2 times a day (every 12 hours) for 1 to 2 days after the completion of chemotherapy Parenteral: 6 months to 18 years: -Recommended dose: 0.15 mg/kg IV, with the first dose (infused over 15 minutes) 30 minutes before the start of emetogenic chemotherapy, and subsequent doses given 4 and 8 hours after the first dose -Maximum dose: 16 mg (per dose) Comments: -The injection formulation should be diluted in 50 mL prior to IV administration. -This drug should be used to prevent nausea and vomiting associated with moderately to highly emetogenic chemotherapy. Uses: -Prevention of nausea and vomiting associated with moderately emetogenic cancer chemotherapy -Prevention of nausea and vomiting associated with initial and repeat courses of emetogenic chemotherapy   What other drugs will affect ondansetron? Ondansetron can cause a serious heart problem, especially if you use certain medicines at the same time, including antibiotics, antidepressants, heart rhythm medicine, antipsychotic medicines, and medicines to treat cancer, malaria, HIV or AIDS. Tell your doctor about all medicines you use, and those you start or stop using during your treatment with ondansetron. Taking ondansetron while you are using certain other medicines can cause high levels of serotonin to build up in your body, a condition called "serotonin syndrome," which can be fatal. Tell your doctor if you also use: medicine to treat depression; medicine to treat a psychiatric disorder; a narcotic (opioid) medication; or medicine to prevent nausea and vomiting. This list is not complete and many other drugs can interact with ondansetron. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.

What is ondansetron? Ondansetron blocks the actions of chemicals in the body that can trigger nausea and vomiting. Ondansetron is used to prevent nausea and vomiting that may be caused by surgery, cancer chemotherapy, or radiation treatment. Ondansetron may be used for purposes not listed in this medication guide. Warnings You should not use ondansetron if you are also using apomorphine (Apokyn). You should not use ondansetron if you are allergic to it or to similar medicines such as dolasetron (Anzemet), granisetron (Kytril), or palonosetron (Aloxi). Before taking ondansetron, tell your doctor if you have liver disease, or a personal or family history of Long QT syndrome. Ondansetron orally disintegrating tablets may contain phenylalanine. Tell your doctor if you have phenylketonuria (PKU). Serious side effects of ondansetron include blurred vision or temporary vision loss (lasting from only a few minutes to several hours), slow heart rate, trouble breathing, anxiety, agitation, shivering, feeling like you might pass out, and urinating less than usual or not at all. Stop taking this medicine and call your doctor at once if you have any of these side effects. Ondansetron may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Before taking ondansetron You should not use ondansetron if: you are also using apomorphine (Apokyn); or you are allergic to ondansetron or similar medicines (dolasetron, granisetron, palonosetron). To make sure ondansetron is safe for you, tell your doctor if you have: liver disease; an electrolyte imbalance (such as low levels of potassium or magnesium in your blood); congestive heart failure, slow heartbeats; a personal or family history of long QT syndrome; or a blockage in your digestive tract (stomach or intestines). Ondansetron is not expected to harm an unborn baby. Tell your doctor if you are pregnant. It is not known whether ondansetron passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby. Ondansetron is not approved for use by anyone younger than 4 years old. Ondansetron orally disintegrating tablets may contain phenylalanine. Tell your doctor if you have phenylketonuria (PKU). How should I take ondansetron? Take ondansetron exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. Ondansetron can be taken with or without food. The first dose is usually taken before the start of your surgery, chemotherapy, or radiation treatment. Follow your doctor's dosing instructions very carefully. Take the ondansetron regular tablet with a full glass of water. To take the orally disintegrating tablet (Zofran ODT): Keep the tablet in its blister pack until you are ready to take it. Open the package and peel back the foil. Do not push a tablet through the foil or you may damage the tablet. Use dry hands to remove the tablet and place it in your mouth. Do not swallow the tablet whole. Allow it to dissolve in your mouth without chewing. Swallow several times as the tablet dissolves. To use ondansetron oral soluble film (strip) (Zuplenz): Keep the strip in the foil pouch until you are ready to use the medicine. Using dry hands, remove the strip and place it on your tongue. It will begin to dissolve right away. Do not swallow the strip whole. Allow it to dissolve in your mouth without chewing. Swallow several times after the strip dissolves. If desired, you may drink liquid to help swallow the dissolved strip. Wash your hands after using Zuplenz. Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one. Store at room temperature away from moisture, heat, and light. Store liquid medicine in an upright position. What happens if I miss a dose? Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include sudden loss of vision, severe constipation, feeling light-headed, or fainting. What to avoid Ondansetron may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Ondansetron side effects Get emergency medical help if you have signs of an allergic reaction to ondansetron: rash, hives; fever, chills, difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: severe constipation, stomach pain, or bloating; headache with chest pain and severe dizziness, fainting, fast or pounding heartbeats; fast or pounding heartbeats; jaundice (yellowing of the skin or eyes); blurred vision or temporary vision loss (lasting from only a few minutes to several hours); high levels of serotonin in the body--agitation, hallucinations, fever, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, fainting. Common ondansetron side effects may include: diarrhea or constipation; headache; drowsiness; or tired feeling. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Dosing information Usual Adult Dose of Ondansetron for Nausea/Vomiting -- Chemotherapy Induced: Oral: Highly Emetogenic Cancer Chemotherapy (HEC): -Recommended dose: 24 mg orally 30 minutes before the start of single-day HEC (including cisplatin doses of 50 mg/m2 or greater) Moderately Emetogenic Cancer Chemotherapy (MEC): -Recommended dose: 8 mg orally twice a day, with the first dose administered 30 minutes before the start of chemotherapy and the subsequent dose 8 hours later; then 8 mg orally 2 times a day (every 12 hours) for 1 to 2 days after the completion of chemotherapy Parenteral: -Recommended dose: 0.15 mg/kg IV, with the first dose (infused over 15 minutes) 30 minutes before the start of emetogenic chemotherapy and subsequent doses given 4 and 8 hours after the first dose. -Maximum dose: 16 mg per dose Comments: -Multi-day, single-dose administration of 24 mg orally for HEC has not been studied. -The injection formulation should be diluted prior to IV administration. Uses: -Prevention of nausea and vomiting associated with HEC or MEC -Prevention of nausea and vomiting associated with initial and repeat courses of emetogenic chemotherapy Usual Adult Dose of Ondansetron for Nausea/Vomiting: Oral: Highly Emetogenic Cancer Chemotherapy (HEC): -Recommended dose: 24 mg orally 30 minutes before the start of single-day HEC (including cisplatin doses of 50 mg/m2 or greater) Moderately Emetogenic Cancer Chemotherapy (MEC): -Recommended dose: 8 mg orally twice a day, with the first dose administered 30 minutes before the start of chemotherapy and the subsequent dose 8 hours later; then 8 mg orally 2 times a day (every 12 hours) for 1 to 2 days after the completion of chemotherapy Parenteral: -Recommended dose: 0.15 mg/kg IV, with the first dose (infused over 15 minutes) 30 minutes before the start of emetogenic chemotherapy and subsequent doses given 4 and 8 hours after the first dose. -Maximum dose: 16 mg per dose Comments: -Multi-day, single-dose administration of 24 mg orally for HEC has not been studied. -The injection formulation should be diluted prior to IV administration. Uses: -Prevention of nausea and vomiting associated with HEC or MEC -Prevention of nausea and vomiting associated with initial and repeat courses of emetogenic chemotherapy Usual Adult Dose of Ondansetron for Nausea/Vomiting -- Postoperative: Oral: -Recommended dose: 16 mg orally 1 hour before the induction of anesthesia Parenteral: -Recommended dose: 4 mg IV (undiluted) immediately before induction of anesthesia or postoperatively (nausea and/or vomiting within 2 hours after surgery) -Alternative route: 4 mg IM (undiluted) Comment: -Administration of a second dose does not provide additional control of nausea and vomiting. Use: -Prevention of postoperative nausea and vomiting Usual Adult Dose for Nausea/Vomiting--Radiation Induced: Recommended dose: 8 mg orally 3 times a day -Total Body Irradiation: 8 mg orally 1 to 2 hours before each fraction of radiotherapy administered each day -Single High-dose Fraction Radiotherapy to the Abdomen: 8 mg orally 1 to 2 hours before radiotherapy, with subsequent doses every 8 hours after the first dose for 1 to 2 days after the completion of radiotherapy -Daily Fractionated Radiotherapy to the Abdomen: 8 mg orally 1 to 2 hours before radiotherapy, with subsequent doses every 8 hours after the first dose for each day radiotherapy is given Use: -Prevention of nausea and vomiting associated with radiotherapy, either as total body irradiation, single high-dose fraction, or daily fractions to the abdomen Usual Pediatric Dose for Nausea/Vomiting -- Postoperative: Parenteral: 1 month to 12 years: Less than 40 kg: -Recommended dose: 0.1 mg/kg IV over 2 to 5 minutes immediately prior to/following anesthesia induction or postoperatively (nausea and/or vomiting occurring shortly after surgery) 40 kg and greater: -Recommended dose: 4 mg IV over 2 to 5 minutes immediately prior to/following anesthesia induction or postoperatively (nausea and/or vomiting occurring shortly after surgery) Use: -Prevention of postoperative nausea and vomiting Usual Pediatric Dose for Nausea/Vomiting -- Chemotherapy Induced: Oral: 4 to 11 years: -Recommended dose: 4 mg orally 3 times a day, with the first dose administered 30 minutes before the start of chemotherapy, and subsequent doses 4 and 8 hours after the first dose; then 4 mg orally 3 times a day (every 8 hours) for 1 to 2 days after the completion of chemotherapy 12 years and older: -Recommended dose: 8 mg orally twice a day, with the first dose administered 30 minutes before the start of chemotherapy and the subsequent dose 8 hours later; then 8 mg orally 2 times a day (every 12 hours) for 1 to 2 days after the completion of chemotherapy Parenteral: 6 months to 18 years: -Recommended dose: 0.15 mg/kg IV, with the first dose (infused over 15 minutes) 30 minutes before the start of emetogenic chemotherapy, and subsequent doses given 4 and 8 hours after the first dose -Maximum dose: 16 mg (per dose) Comments: -The injection formulation should be diluted in 50 mL prior to IV administration. -This drug should be used to prevent nausea and vomiting associated with moderately to highly emetogenic chemotherapy. Uses: -Prevention of nausea and vomiting associated with moderately emetogenic cancer chemotherapy -Prevention of nausea and vomiting associated with initial and repeat courses of emetogenic chemotherapy   What other drugs will affect ondansetron? Ondansetron can cause a serious heart problem, especially if you use certain medicines at the same time, including antibiotics, antidepressants, heart rhythm medicine, antipsychotic medicines, and medicines to treat cancer, malaria, HIV or AIDS. Tell your doctor about all medicines you use, and those you start or stop using during your treatment with ondansetron. Taking ondansetron while you are using certain other medicines can cause high levels of serotonin to build up in your body, a condition called "serotonin syndrome," which can be fatal. Tell your doctor if you also use: medicine to treat depression; medicine to treat a psychiatric disorder; a narcotic (opioid) medication; or medicine to prevent nausea and vomiting. This list is not complete and many other drugs can interact with ondansetron. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.

What is oxandrolone? Oxandrolone is a man-made steroid, similar to the naturally occurring steroid testosterone. Oxandrolone is an "anabolic" steroid that promotes the growth of muscle tissue. Oxandrolone is used to help you regain weight lost after surgery, severe trauma, or chronic infections. Oxandrolone is also used in people who cannot gain or maintain a healthy weight for unknown medical reasons. Oxandrolone is also used to decrease muscle loss caused by using steroid medicines, and to reduce bone pain in people with osteoporosis. Oxandrolone may also be used for purposes not listed in this medication guide. Warnings You should not use oxandrolone if you have prostate cancer, advanced kidney disease, high levels of calcium in your blood, breast cancer, or if you are pregnant. Some people using anabolic steroid medicine have developed life-threatening side effects on the liver, spleen, and blood vessels. These conditions can occur without warning or symptoms and can lead to liver failure, internal bleeding, cancer, stroke, heart attack, or death. Talk with your doctor about the risks and benefits of using oxandrolone. Before taking this medicine You should not use oxandrolone if you are allergic to it, or if you have prostate cancer; advanced kidney disease; high levels of calcium in your blood (hypercalcemia); breast cancer (in men or in women who have hypercalcemia); or if you are pregnant. Some people using anabolic steroid medicine have developed cysts or tumors of the liver or spleen. These conditions can occur without warning or symptoms and can lead to liver failure, internal bleeding, cancer, or death. Using anabolic steroid medicine may also cause cholesterol (lipid) changes within your blood, which can increase fatty buildup inside your arteries (also called atherosclerosis). This condition can lead to stroke or heart attack. Talk with your doctor about the risks and benefits of using oxandrolone. To make sure oxandrolone is safe for you, tell your doctor if you have: liver disease; a history of heart disease; high cholesterol or triglycerides (a type of fat in the blood); diabetes; a thyroid disorder; chronic obstructive pulmonary disease (COPD); a history of stroke or blood clots; if you take a blood thinner (warfarin, Coumadin, Jantoven); or if you use other steroid medicines (prednisone, methylprednisolone, and others). This medicine can harm an unborn baby or cause birth defects. Do not use if you are pregnant. Use effective birth control and tell your doctor right away if you become pregnant during treatment. It is not known whether oxandrolone passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine. Older men may have an increased risk of developing an enlarged prostate or prostate cancer while taking this medicine. Talk with your doctor about your individual risk. How should I take oxandrolone? Oxandrolone is usually given for only a few weeks. Follow all directions on your prescription label. Do not take oxandrolone in larger or smaller amounts or for longer than recommended. Oxandrolone will not enhance athletic performance and should not be used for that purpose. Oxandrolone may be habit-forming. Never share oxandrolone with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it. If a child is taking this medicine, tell your doctor if the child has any changes in weight. Oxandrolone doses are based on weight in children. While using oxandrolone, you will need frequent blood tests. Your kidney function may also need to be checked with urine tests. Oxandrolone can cause bone overgrowth in children, especially young children. Bone development may need to be checked with x-rays every 6 months during treatment. Store at room temperature away from moisture and heat. Keep track of the amount of medicine used from each new bottle. Oxandrolone is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription. What happens if I miss a dose? Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking oxandrolone? Follow your doctor's instructions about any restrictions on food, beverages, or activity. Oxandrolone side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: new or worsening acne; shortness of breath (even with mild exertion), swelling in your ankles or feet, rapid weight gain; increased or ongoing erection of the penis; unusual penis growth before puberty; impotence, ejaculation problems, decreased amounts of semen, decrease in testicle size; painful or difficult urination; liver problems--nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or high levels of calcium in your blood--vomiting, stomach pain, constipation, increased thirst or urination, muscle pain or weakness, joint pain, confusion, and feeling tired or restless. Women receiving oxandrolone may develop male characteristics, which could be irreversible if testosterone treatment is continued. Stop taking oxandrolone and call your doctor at once if you notice any of these signs of excess testosterone: acne; changes in menstrual periods; male-pattern hair growth (such as on the chin or chest); hoarse or deepened voice; or enlarged clitoris. Common side effects (in men or women) may include: breast swelling; feeling excited; sleep problems (insomnia); or increased or decreased interest in sex. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Oxandrolone dosing information Usual Adult Dose for Weight Loss: 2.5 mg to 20 mg orally in 2 to 4 divided doses Duration of therapy: 2 to 4 weeks, may be repeated intermittently as indicated. Uses: -Adjunctive therapy to promote weight gain after weight loss following extensive surgery, chronic infections, or severe trauma, and in some patients who without definite pathophysiologic reasons fail to gain or to maintain normal weight -To offset the protein catabolism associated with prolonged administration of corticosteroids -For the relief of the bone pain frequently accompanying osteoporosis Usual Geriatric Dose for Weight Loss: 5 mg orally twice a day Uses: -Adjunctive therapy to promote weight gain after weight loss following extensive surgery, chronic infections, or severe trauma, and in some patients who without definite pathophysiologic reasons fail to gain or to maintain normal weight -To offset the protein catabolism associated with prolonged administration of corticosteroids -For the relief of the bone pain frequently accompanying osteoporosis Usual Pediatric Dose for Weight Loss: Less than or equal to 0.1 mg per kg body weight, may be repeated intermittently as indicated. Uses: -Adjunctive therapy to promote weight gain after weight loss following extensive surgery, chronic infections, or severe trauma, and in some patients who without definite pathophysiologic reasons fail to gain or to maintain normal weight -To offset the protein catabolism associated with prolonged administration of corticosteroids -For the relief of the bone pain frequently accompanying osteoporosis   What other drugs will affect oxandrolone? Other drugs may interact with oxandrolone, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

What is oxcarbazepine? Oxcarbazepine is an anticonvulsant. It works by decreasing nerve impulses that cause seizures and pain. Oxcarbazepine is used either alone or with other medicines to treat partial seizures. The Trileptal brand of oxcarbazepine is used as a single medicine in adults and children who are at least 4 years old. Trileptal is used with other medicines in adults and children who are at least 2 years old. The Oxtellar XR brand of oxcarbazepine is used with other medicines in adults and children who are at least 6 years old. Oxcarbazepine may also be used for purposes not listed in this medication guide. Warnings Seek medical treatment if you have symptoms of a serious drug reaction: skin rash, fever, swollen glands, flu-like symptoms, unusual bruising or bleeding, or yellowing of your skin or eyes. Call your doctor right away if you have symptoms of low sodium levels in your body, such as nausea, confusion, severe weakness, muscle pain, or increased seizures. Some people have thoughts about suicide while taking seizure medicine. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor. Do not stop using oxcarbazepine suddenly. Before taking this medicine You should not take oxcarbazepine if you are allergic to oxcarbazepine or eslicarbazepine. Tell your doctor if you have ever had: liver disease; kidney disease; mood problems or suicidal thoughts; or an allergy to carbamazepine (Carbatrol, Tegretol). Some people have thoughts about suicide while taking oxcarbazepine. Your doctor will need to check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms. Do not start or stop taking oxcarbazepine during pregnancy without your doctor's advice. Having a seizure during pregnancy could harm both mother and baby. Tell your doctor right away if you become pregnant while taking oxcarbazepine for seizures. If you are pregnant, your name may be listed on a pregnancy registry to track the effects of oxcarbazepine on the baby. Oxcarbazepine can make birth control pills less effective. Ask your doctor about using a non-hormonal birth control (condom, diaphragm with spermicide) to prevent pregnancy. You should not breast-feed while you are taking oxcarbazepine. Do not give this medicine to a child without medical advice. There are specific age restrictions for the use of oxcarbazepine in children, depending on the dose form and whether it is used alone or with other medicines. How should I take oxcarbazepine? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Shake the oral suspension (liquid) before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon). Give the liquid directly from the oral syringe, or mix the medicine with a small glass of water. After using the syringe, rinse it with water and allow it to air dry. Take the oxcarbazepine extended-release tablet on an empty stomach, at least 1 hour before or 2 hours after a meal. You may take the oxcarbazepine oral liquid or regular tablet with or without food. Swallow the extended-release tablet whole and do not crush, chew, or break it. You may need frequent blood tests. Do not stop using oxcarbazepine suddenly, even if you feel fine. Stopping suddenly may cause increased seizures. Follow your doctor's instructions about tapering your dose. In case of emergency, wear or carry medical identification to let others know you use oxcarbazepine. Seizures are often treated with a combination of drugs. Use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor's advice. Store at room temperature away from moisture and heat. Throw away any unused liquid 7 weeks after opening the bottle.   What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking oxcarbazepine? Do not drink alcohol. Drinking alcohol can increase certain side effects, and may increase the risk of seizures. Avoid becoming overheated or dehydrated during exercise, in hot weather, or by not drinking enough fluids. Follow your doctor's instructions about the type and amount of liquids you should drink. Avoid driving or hazardous activity until you know how oxcarbazepine will affect you. Your reactions could be impaired. Oxcarbazepine side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, flu-like symptoms, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes. Oxcarbazepine can reduce the sodium in your body to dangerously low levels, which can cause a life-threatening electrolyte imbalance. Call your doctor right away if you have nausea, lack of energy, confusion, feeling tired or irritable, severe weakness, muscle pain, or increased seizures. Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, depression, anxiety, or if you feel agitated, hostile, restless, hyperactive (mentally or physically), or have thoughts about suicide or hurting yourself. Common side effects may include: dizziness, drowsiness, tiredness; balance or coordination problems; nausea, vomiting; tremors or shaking; double vision; or rash. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect oxcarbazepine? Using oxcarbazepine with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures. Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective. Many drugs can affect oxcarbazepine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

What is oxybutynin? Oxybutynin reduces muscle spasms of the bladder and urinary tract. Oxybutynin is used to treat symptoms of overactive bladder, such as frequent or urgent urination, incontinence (urine leakage), and increased night-time urination. Oxybutynin is also used in children at least 6 years old with overactive bladder related to a neurologic condition such as spina bifida. Warnings You should not use oxybutynin if you have untreated or uncontrolled narrow-angle glaucoma, a blockage in your digestive tract (stomach or intestines), or if you are unable to urinate. Before using oxybutynin, tell your doctor if you have glaucoma, liver or kidney disease, an enlarged prostate, myasthenia gravis, ulcerative colitis, a blockage in your stomach or intestines, or a stomach disorder such as gastroesophageal reflux disease (GERD) or slow digestion. Avoid becoming overheated or dehydrated during exercise and in hot weather. Oxybutynin can decrease perspiration and you may be more prone to heat stroke. This medication may cause blurred vision and may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly. There are many other medicines that can interact with oxybutynin. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you. Stop using this medication and call your doctor if you have serious side effects such as hot and dry skin, extreme thirst, severe stomach pain or constipation, pain or burning when you urinate, or if you stop urinating. Before taking this medicine You should not use oxybutynin if you are allergic to it, or if you have: untreated or uncontrolled narrow-angle glaucoma; a blockage in your digestive tract (stomach or intestines); or if you are unable to urinate. To make sure you can safely take oxybutynin, tell your doctor if you have ever had: glaucoma; trouble urinating; ulcerative colitis; Parkinson's disease; dementia; a nerve disorder that affects your heart rate, blood pressure, or digestion; myasthenia gravis; or a stomach disorder such as gastroesophageal reflux disease (GERD) or slow digestion. Tell your doctor if you are pregnant or breastfeeding. How should I take oxybutynin? Take oxybutynin exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Take this medicine with a full glass of water, at the same time each day. You may take oxybutynin with or without food. Swallow the extended-release tablet whole and do not crush, chew, or break it. Measure liquid medicine with the supplied measuring device (not a kitchen spoon). Some tablets are made with a shell that is not absorbed or melted in the body. Part of this shell may appear in your stool. This is normal and will not make the medicine less effective. Store at room temperature away from moisture and heat.   What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while using oxybutynin? Avoid driving or hazardous activity until you know how oxybutynin will affect you. Your reactions could be impaired. Avoid becoming overheated or dehydrated during exercise and in hot weather. Oxybutynin can decrease sweating and you may be more prone to heat stroke. Drinking alcohol with this medicine can increase side effects. Oxybutynin side effects Get emergency medical help if you have signs of an allergic reaction to oxybutynin: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using this medicine and call your doctor at once if you have: severe stomach pain or constipation; blurred vision, tunnel vision, eye pain, or seeing halos around lights; little or no urination; painful or difficult urination; or dehydration - dizziness, confusion, feeling very thirsty, less urination or sweating. Common oxybutynin side effects may include: dizziness, drowsiness; headache; dry mouth; or diarrhea, constipation. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect oxybutynin? Using oxybutynin with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures. Tell your doctor about all your other medicines, especially: antibiotic, antifungal, or antiviral medicine; bronchodilator asthma medication; cold or allergy medicine (Benadryl and others); medicine to treat overactive bladder; medicine to treat dementia; medicine to treat Parkinson's disease; or medicine to treat stomach problems, motion sickness, or irritable bowel syndrome. This list is not complete. Other drugs may interact with oxybutynin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.  

What is oxybutynin? Oxybutynin reduces muscle spasms of the bladder and urinary tract. Oxybutynin is used to treat symptoms of overactive bladder, such as frequent or urgent urination, incontinence (urine leakage), and increased night-time urination. Oxybutynin is also used in children at least 6 years old with overactive bladder related to a neurologic condition such as spina bifida. Warnings You should not use oxybutynin if you have untreated or uncontrolled narrow-angle glaucoma, a blockage in your digestive tract (stomach or intestines), or if you are unable to urinate. Before using oxybutynin, tell your doctor if you have glaucoma, liver or kidney disease, an enlarged prostate, myasthenia gravis, ulcerative colitis, a blockage in your stomach or intestines, or a stomach disorder such as gastroesophageal reflux disease (GERD) or slow digestion. Avoid becoming overheated or dehydrated during exercise and in hot weather. Oxybutynin can decrease perspiration and you may be more prone to heat stroke. This medication may cause blurred vision and may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly. There are many other medicines that can interact with oxybutynin. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you. Stop using this medication and call your doctor if you have serious side effects such as hot and dry skin, extreme thirst, severe stomach pain or constipation, pain or burning when you urinate, or if you stop urinating. Before taking this medicine You should not use oxybutynin if you are allergic to it, or if you have: untreated or uncontrolled narrow-angle glaucoma; a blockage in your digestive tract (stomach or intestines); or if you are unable to urinate. To make sure you can safely take oxybutynin, tell your doctor if you have ever had: glaucoma; trouble urinating; ulcerative colitis; Parkinson's disease; dementia; a nerve disorder that affects your heart rate, blood pressure, or digestion; myasthenia gravis; or a stomach disorder such as gastroesophageal reflux disease (GERD) or slow digestion. Tell your doctor if you are pregnant or breastfeeding. How should I take oxybutynin? Take oxybutynin exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Take this medicine with a full glass of water, at the same time each day. You may take oxybutynin with or without food. Swallow the extended-release tablet whole and do not crush, chew, or break it. Measure liquid medicine with the supplied measuring device (not a kitchen spoon). Some tablets are made with a shell that is not absorbed or melted in the body. Part of this shell may appear in your stool. This is normal and will not make the medicine less effective. Store at room temperature away from moisture and heat.   What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while using oxybutynin? Avoid driving or hazardous activity until you know how oxybutynin will affect you. Your reactions could be impaired. Avoid becoming overheated or dehydrated during exercise and in hot weather. Oxybutynin can decrease sweating and you may be more prone to heat stroke. Drinking alcohol with this medicine can increase side effects. Oxybutynin side effects Get emergency medical help if you have signs of an allergic reaction to oxybutynin: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using this medicine and call your doctor at once if you have: severe stomach pain or constipation; blurred vision, tunnel vision, eye pain, or seeing halos around lights; little or no urination; painful or difficult urination; or dehydration - dizziness, confusion, feeling very thirsty, less urination or sweating. Common oxybutynin side effects may include: dizziness, drowsiness; headache; dry mouth; or diarrhea, constipation. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect oxybutynin? Using oxybutynin with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures. Tell your doctor about all your other medicines, especially: antibiotic, antifungal, or antiviral medicine; bronchodilator asthma medication; cold or allergy medicine (Benadryl and others); medicine to treat overactive bladder; medicine to treat dementia; medicine to treat Parkinson's disease; or medicine to treat stomach problems, motion sickness, or irritable bowel syndrome. This list is not complete. Other drugs may interact with oxybutynin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.  

What is Pacerone? Pacerone affects the rhythm of your heartbeats. Pacerone is used to help keep the heart beating normally in people with life-threatening heart rhythm disorders of the ventricles (the lower chambers of the heart that allow blood to flow out of the heart). This medicine is used to treat ventricular tachycardia or ventricular fibrillation. Pacerone is for use only in treating life-threatening heart rhythm disorders. Pacerone may also be used for purposes not listed in this medication guide. Warnings Pacerone is for use only in treating life-threatening heart rhythm disorders. You should not take Pacerone if you are allergic to Pacerone or iodine, or if you have heart block, a history of slow heartbeats that have caused you to faint, or if your heart cannot pump blood properly. Pacerone can cause dangerous side effects on your heart, liver, lungs, or vision. Call your doctor or get medical help at once if you have: chest pain, fast or pounding heartbeats, trouble breathing, vision problems, upper stomach pain, vomiting, dark urine, jaundice (yellowing of the skin or eyes), or if you cough up blood. Before taking this medicine You should not use this medicine if you are allergic to Pacerone or iodine, or if you have: a serious heart condition called "AV block" (2nd or 3rd degree), unless you have a pacemaker; a history of slow heartbeats that have caused you to faint; or if your heart cannot pump blood properly. Pacerone can cause dangerous side effects on your heart, liver, lungs, or thyroid. Tell your doctor if you have ever had: asthma or another lung disorder; liver disease; a thyroid disorder; vision problems; high or low blood pressure; an electrolyte imbalance (such as low levels of potassium or magnesium in your blood); or if you have a pacemaker or defibrillator implanted in your chest. Taking Pacerone during pregnancy may harm an unborn baby, or cause thyroid problems or abnormal heartbeats in the baby after it is born. This medicine may also affect the child's growth or development (speech, movement, academic skills) later in life. Tell your doctor if you are pregnant or if you become pregnant. You should not breast-feed while taking Pacerone, and for several months after stopping. This medicine takes a long time to clear from your body. Talk to your doctor about the best way to feed your baby during this time. How should I take Pacerone? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. You will receive your first few doses in a hospital setting, where your heart rhythm can be monitored. If you have been taking another heart rhythm medicine, you may need to gradually stop taking it when you start using Pacerone. Follow your doctor's dosing instructions very carefully. You may take Pacerone with or without food, but take it the same way each time. It may take up to 3 weeks before your heart rhythm improves. Keep using the medicine as directed even if you feel well. Pacerone can have long lasting effects on your body. You may need frequent medical tests while using Pacerone and for several months after your last dose. If you need surgery (including laser eye surgery), tell the surgeon ahead of time that you are using Pacerone. This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using Pacerone. Store at room temperature away from moisture, heat, and light.   What happens if I miss a dose? Skip the missed dose and use your next dose at the regular time. Do not use two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of Pacerone can be fatal. Overdose symptoms may include weakness, slow heart rate, feeling light-headed, or loss of consciousness. What should I avoid while taking amiodarone? Avoid driving or hazardous activity until you know how Pacerone will affect you. Your reactions could be impaired. Grapefruit may interact with Pacerone and lead to unwanted side effects. Avoid the use of grapefruit products. Avoid taking an herbal supplement containing St. John's wort. Pacerone could make you sunburn more easily. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors. Pacerone side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Pacerone takes a long time to completely clear from your body. You may continue to have side effects from this medicine after you stop using it. Call your doctor at once if you have any of these side effects, even if they occur up to several months after you stop using Pacerone: wheezing, cough, chest pain, cough with bloody mucus, fever; a new or a worsening irregular heartbeat pattern (fast, slow, or pounding heartbeats); a light-headed feeling, like you might pass out; blurred vision, seeing halos around lights (your eyes may be more sensitive to light); liver problems--nausea, vomiting, stomach pain (upper right side), tiredness, dark urine, jaundice (yellowing of the skin or eyes); nerve problems--loss of coordination, muscle weakness, uncontrolled muscle movement, or a prickly feeling in your hands or lower legs; signs of overactive thyroid--weight loss, thinning hair, feeling hot, increased sweating, tremors, feeling nervous or irritable, irregular menstrual periods, swelling in your neck (goiter); or signs of underactive thyroid--weight gain, tiredness, depression, trouble concentrating, feeling cold. Common side effects may include: nausea, vomiting, loss of appetite; or constipation. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect Pacerone? Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective. Pacerone takes a long time to completely clear from your body. Drug interactions are possible for up to several months after you stop using this medicine. Talk to your doctor before taking any medication during this time. Keep track of how long it has been since your last dose of amiodarone. Many drugs can affect Pacerone. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

What is Panretin? Panretin (for the skin) is used in adults to treat skin lesions caused by AIDS-related Kaposi's sarcoma. Panretin may also be used for purposes not listed in this medication guide. Warnings Use only as directed. Tell your doctor if you use other medicines or have other medical conditions or allergies. Before taking this medicine You should not use Panretin if you are allergic to alitretinoin, isotretinoin, or tretinoin (Retin-A). May harm an unborn baby. Do not use if you are pregnant. Use effective birth control while using Panretin. Tell your doctor if you become pregnant. Do not breastfeed. How should I use Panretin? Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. Do not take by mouth. Topical medicine is for use only on the skin. Wash your hands before and after using this medicine, unless you are treating skin areas on your hands. Panretin is usually applied 2 to 4 times per day at evenly spaced intervals. Apply only to affected skin lesions, avoiding healthy skin around the lesions. Allow the gel to dry for 3 to 5 minutes before covering treated skin with clothing. Do not cover the treated skin area with a bandage unless your doctor tells you to. Do not bathe, shower, or swim within 20 minutes before or 3 hours after applying the medicine. Alitretinoin gel is flammable. Do not use near high heat or open flame. Do not smoke until the gel has completely dried on your skin. It may take up to 14 weeks or longer before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve. Store at room temperature away from moisture and heat. Keep the medicine away from open flame or high heat.   What happens if I miss a dose? Apply the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not apply two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medicine. What should I avoid while using Panretin? Avoid getting Panretin in your eyes, nose, mouth, lips, rectum, tip of the penis or vagina. If this does happen, rinse with water. Do not use insect repellents or other products that contain DEET (N,N-diethyl-m-toluamide) while using Panretin. Avoid using other medications on the areas you treat with Panretin. You may use mineral oil to help prevent dryness and itching. Do not apply mineral oil within 2 hours before or 2 hours after using this medicine. Panretin could make you sunburn more easily. Avoid sunlight or tanning beds. Wear protective clothing when you are outdoors. Panretin side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: severe burning, pain, or irritation after using this medicine; blistering, drainage, oozing; or severe redness or swelling. Serious side effects may be more likely if you also have T-cell lymphoma. Common side effects may include: rash, itching, redness, or other skin irritation; skin peeling or flaking; scabs or crusting; or pain or burning of treated skin. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect Panretin? Medicine used on the skin is not likely to be affected by other drugs you use, but many drugs can interact. Tell your doctor about all your current medicines, including prescription and over-the-counter medicines, vitamins, and herbal products.

What is pantoprazole? Pantoprazole is a proton pump inhibitor that decreases the amount of acid produced in the stomach. Pantoprazole is used to treat erosive esophagitis (damage to the esophagus from stomach acid caused by gastroesophageal reflux disease, or GERD) in adults and children who are at least 5 years old. Pantoprazole is usually given for up to 8 weeks at a time while your esophagus heals. Pantoprazole is also used to treat Zollinger-Ellison syndrome and other conditions involving excess stomach acid. Warnings Pantoprazole is not for the immediate relief of heartburn symptoms. Heartburn is often confused with the first symptoms of a heart attack. Seek emergency medical attention if you have chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, and a general ill feeling. Long-term treatment with pantoprazole may also make it harder for your body to absorb vitamin B-12, resulting in a deficiency of this vitamin. Talk with your doctor if you need long-term pantoprazole treatment and you have concerns about vitamin B-12 deficiency. Pantoprazole can cause kidney problems. Tell your doctor if you are urinating less than usual, or if you have blood in your urine. Diarrhea may be a sign of a new infection. Call your doctor if you have diarrhea that is watery or has blood in it. Pantoprazole may cause new or worsening symptoms of lupus. Tell your doctor if you have joint pain and a skin rash on your cheeks or arms that worsens in sunlight. You may be more likely to have a broken bone while taking this medicine long term or more than once per day. Before taking this medicine Heartburn can mimic early symptoms of a heart attack. Get emergency medical help if you have chest pain that spreads to your jaw or shoulder and you feel anxious or light-headed. You should not use this medicine if: you also take medicine that contains rilpivirine (Edurant, Complera, Juluca, Odefsey); if you had breathing problems, kidney problems, or a severe allergic reaction after taking pantoprazole in the past; or you are allergic to pantoprazole or similar medicines (lansoprazole, omeprazole, Nexium, Prevacid, Prilosec, and others). Tell your doctor if you have ever had: low levels of magnesium in your blood; lupus; or osteoporosis or low bone mineral density. You may be more likely to have a broken bone while using pantoprazole long-term or more than once per day. Talk with your doctor about ways to keep your bones healthy, especially if you are an adult over 50. It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. You should not breast-feed while using this medicine. Pantoprazole is not approved for use by anyone younger than 5 years old. How should I use pantoprazole? Take pantoprazole exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. Use the lowest dose for the shortest amount of time needed to treat your condition. Pantoprazole is taken by mouth (oral) or given as an infusion into a vein (injection). A healthcare provider may teach you how to properly use the injection by yourself. Pantoprazole tablets are taken by mouth, with or without food. The oral granules should be taken 30 minutes before a meal. Do not crush, chew, or break the tablet. Swallow it whole. The oral granules should be mixed with applesauce or apple juice and given either by mouth or through a nasogastric (NG) tube. Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you have any questions. Use this medicine for the full prescribed length of time, even if your symptoms quickly improve. Call your doctor if your symptoms do not improve or if they get worse while you are using this medicine. Pantoprazole can cause false results with certain medical tests. Tell the doctor or laboratory staff that you are using this medicine. Pantoprazole may also affect a drug-screening urine test and you may have false results. Tell the laboratory staff that you use this medicine. Store this medicine at room temperature away from moisture, heat, and light. Dosing information Usual Adult Dose for Erosive Esophagitis: Treatment of Erosive Esophagitis: 40 mg orally once a day for up to 8 weeks; however an additional 8 weeks may be considered for patients who have not healed after the initial treatment. Safety and efficacy beyond 16 weeks of therapy have not been established. Maintenance of Healing of Erosive Esophagitis: 40 mg orally once a day. Controlled studies have been limited to 12 months of pantoprazole therapy. Usual Adult Dose for Gastroesophageal Reflux Disease: Parenteral: 40 mg once a day for 7 to 10 days, administered via intravenous infusion over a period of 15 minutes. Intravenous therapy should be discontinued as soon as the patient is able to resume oral therapy. Oral: 40 mg orally once a day, for short-term administration (up to 8 weeks); however an additional 8 weeks may be considered for patients who have not healed after the initial treatment. Safety and efficacy beyond 16 weeks of therapy have not been established. Usual Adult Dose for Duodenal Ulcer: Study (n=54) 40 mg orally once a day, dose was increased every 12 weeks by 40 mg increments to a maximum of 120 mg per day, for 28 weeks. Data have revealed that monotherapy with daily doses of 40 mg have been associated with complete duodenal ulcer healing in up to 87% and 94% of patients after 4 weeks and 8 weeks respectively. Usual Adult Dose for Gastric Ulcer: 40 mg orally once a day. Data have revealed that monotherapy with daily doses of 40 mg have been associated with complete gastric ulcer healing in up to 87% and 97% of patients after 4 weeks and 8 weeks respectively. Usual Adult Dose for Helicobacter pylori Infection: Study (n=242) - Triple therapy: 40 mg orally twice daily for 7 days, commonly in conjunction with clarithromycin and either amoxicillin or metronidazole to eradicate Helicobacter pylori, followed with 40 mg pantoprazole orally once daily until day 28. Triple therapy has resulted in eradication rates of greater than 95%. The QUADRATE Study (n=405) - Quadruple therapy: 40 mg orally twice daily for 7 days, concomitantly with bismuth subcitrate and tetracycline, both four times daily, and metronidazole 200 mg three times daily and 400 mg at bedtime. Helicobacter Pylori eradication was achieved in 82% of patients. Usual Adult Dose for Zollinger-Ellison Syndrome: Parenteral: 80 mg every 12 hours, administered by 15-minute infusion. Daily doses higher than 240 mg administered in equally divided doses by 15-minute infusion, or administered for more than 6 days have not been studied. Oral: 40 mg twice daily, to a maximum of 240 mg per day. Some patients have received treatment with pantoprazole for more than 2 years. Usual Adult Dose for Stress Ulcer Prophylaxis: Study (n=21) - Stress Ulcer bleeding prophylaxis in the Critical Care Setting: 80 mg twice daily, as a bolus infusion over a period of 15 minutes, to a maximum daily dose of 240 mg, divided into three equal doses. Study (n=20 ) - Peptic Ulcer rebleeding prophylaxis after hemostasis in the Critical Care Setting: 80 mg IV bolus, followed by continuous infusion of 8 mg/hr for 3 days, after which therapy may be continued with an oral PPI. Usual Adult Dose for Peptic Ulcer: Study (n=21) - Stress Ulcer bleeding prophylaxis in the Critical Care Setting: 80 mg twice daily, as a bolus infusion over a period of 15 minutes, to a maximum daily dose of 240 mg, divided into three equal doses. Study (n=20 ) - Peptic Ulcer rebleeding prophylaxis after hemostasis in the Critical Care Setting: 80 mg IV bolus, followed by continuous infusion of 8 mg/hr for 3 days, after which therapy may be continued with an oral PPI.   What happens if I miss a dose? Use the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while using pantoprazole? This medicine can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to. Pantoprazole side effects Get emergency medical help if you have signs of an allergic reaction to pantoprazole: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: severe stomach pain, diarrhea that is watery or bloody; sudden pain or trouble moving your hip, wrist, or back; bruising or swelling where intravenous pantoprazole was injected; kidney problems - fever, rash, nausea, loss of appetite, joint pain, urinating less than usual, blood in your urine, weight gain; low magnesium - dizziness, fast or irregular heart rate, tremors (shaking) or jerking muscle movements, feeling jittery, muscle cramps, muscle spasms in your hands and feet, cough or choking feeling; or new or worsening symptoms of lupus - joint pain, and a skin rash on your cheeks or arms that worsens in sunlight. Taking pantoprazole long-term may cause you to develop stomach growths called fundic gland polyps. Talk with your doctor about this risk. If you use pantoprazole for longer than 3 years, you could develop a vitamin B-12 deficiency. Talk to your doctor about how to manage this condition if you develop it. Common pantoprazole side effects may include: headache, dizziness; stomach pain, gas, nausea, vomiting, diarrhea; joint pain; or fever, rash, or cold symptoms (most common in children). This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect pantoprazole? Tell your doctor about all your other medicines. Some may interact with pantoprazole, especially: digoxin; methotrexate; or a diuretic or "water pill." This list is not complete. Other drugs may affect pantoprazole, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

What is paroxetine? Paroxetine is an antidepressant that belongs to group of drugs called selective serotonin reuptake inhibitors (SSRIs). Paroxetine affects chemicals in the brain that may be unbalanced in people with depression, anxiety, or other disorders. Paroxetine is used to treat depression, including major depressive disorder. Paroxetine is also used to treat panic disorder, obsessive-compulsive disorder (OCD), anxiety disorders, post-traumatic stress disorder (PTSD), and premenstrual dysphoric disorder (PMDD)>. The Brisdelle brand of paroxetine is used to treat hot flashes related to menopause. Brisdelle is not for treating any other conditions. Warnings You should not use paroxetine if you are also taking pimozide or thioridazine. Do not use paroxetine within 14 days before or 14 days after you have used an MAO inhibitor, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine. Some young people have thoughts about suicide when first taking an antidepressant. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor Seek medical attention right away if you have symptoms such as: agitation, hallucinations, muscle stiffness, twitching, loss of coordination, dizziness, warmth or tingly feeling, nausea, vomiting, diarrhea, fever, sweating, tremors, racing heartbeats, or a seizure (convulsions). Do not stop using paroxetine without first asking your doctor. Before taking this medicine You should not use this medicine if you are allergic to paroxetine, or if you are also taking pimozide or thioridazine. Do not use an MAO inhibitor within 14 days before or 14 days after you take paroxetine. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine. After you stop taking paroxetine you must wait at least 14 days before you start taking an MAO inhibitor. To make sure paroxetine is safe for you, tell your doctor if you have: heart disease, high blood pressure, or a stroke; liver or kidney disease; a bleeding or blood clotting disorder; seizures or epilepsy; bipolar disorder (manic depression), drug addiction, or suicidal thoughts; sexual problems; narrow-angle glaucoma; or low levels of sodium in your blood. Be sure your doctor knows if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. These medicines may interact with paroxetine and cause a serious condition called serotonin syndrome. Some young people have thoughts about suicide when first taking an antidepressant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms. Taking an SSRI antidepressant during pregnancy may cause serious lung problems or other complications in the baby. However, you may have a relapse of depression if you stop taking your antidepressant. Tell your doctor right away if you become pregnant. Do not start or stop taking this medicine without your doctor's advice. Do not use Brisdelle if you are pregnant. You should not breastfeed while using this medicine. Paroxetine is not approved for use by anyone younger than 18 years old. How should I take paroxetine? Take paroxetine exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Swallow the extended-release tablet whole and do not crush, chew, or break it. Shake the oral suspension (liquid) before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon). It may take up to 4 weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve. Tell your doctor if you have any changes in sexual function, such as loss of interest in sex, trouble having an orgasm, or (in men) problems with erections or ejaculation. Some sexual problems can be treated. Do not stop using paroxetine suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using paroxetine. Follow your doctor's instructions about tapering your dose. Store at room temperature away from moisture, heat, and light. Detailed Paroxetine dosage information What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of paroxetine can be fatal. What to avoid Avoid driving or hazardous activity until you know how paroxetine will affect you. Your reactions could be impaired. Ask your doctor before taking a nonsteroidal anti-inflammatory drug (NSAID) such as aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib (Celebrex), diclofenac, indomethacin, meloxicam, and others. Using an NSAID with paroxetine may cause you to bruise or bleed easily. Drinking alcohol with this medicine can cause side effects. Paroxetine side effects Get emergency medical help if you have signs of an allergic reaction to paroxetine (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling). Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself. Call your doctor at once if you have: racing thoughts, decreased need for sleep, unusual risk-taking behavior, feelings of extreme happiness or sadness, being more talkative than usual; blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights; unusual bone pain or tenderness, swelling or bruising; changes in weight or appetite; easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), coughing up blood; severe nervous system reaction - very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, fainting; or low levels of sodium in the body - headache, confusion, slurred speech, severe weakness, loss of coordination, feeling unsteady. Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea. Common paroxetine side effects may include: vision changes; weakness, drowsiness, dizziness, tiredness; sweating, anxiety, shaking; sleep problems (insomnia); loss of appetite, nausea, vomiting, diarrhea, constipation; dry mouth, yawning; infection; headache; or decreased sex drive, impotence, abnormal ejaculation, or difficulty having an orgasm. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Paroxetine side effects (more detail) What other drugs will affect paroxetine? Using paroxetine with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures. Tell your doctor about all your other medicines, especially: cimetidine (Tagamet), digoxin, St. John's wort, tamoxifen, theophylline, tryptophan (sometimes called L-tryptophan), warfarin (Coumadin, Jantoven); a diuretic or "water pill"; heart rhythm medicine; HIV or AIDS medications; certain medicines to treat narcolepsy or ADHD - amphetamine, atomoxetine, dextroamphetamine, Adderall, Dexedrine, Evekeo, Vyvanse, and others; narcotic pain medicine - fentanyl, tramadol; medicine to treat anxiety, mood disorders, thought disorders, or mental illness - such as buspirone, lithium, other antidepressants, or antipsychotics; migraine headache medicine - sumatriptan, rizatriptan, zolmitriptan, and others; or seizure medicine - phenobarbital, phenytoin. This list is not complete. Other drugs may interact with paroxetine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

What is paroxetine? Paroxetine is an antidepressant that belongs to group of drugs called selective serotonin reuptake inhibitors (SSRIs). Paroxetine affects chemicals in the brain that may be unbalanced in people with depression, anxiety, or other disorders. Paroxetine is used to treat depression, including major depressive disorder. Paroxetine is also used to treat panic disorder, obsessive-compulsive disorder (OCD), anxiety disorders, post-traumatic stress disorder (PTSD), and premenstrual dysphoric disorder (PMDD)>. The Brisdelle brand of paroxetine is used to treat hot flashes related to menopause. Brisdelle is not for treating any other conditions. Warnings You should not use paroxetine if you are also taking pimozide or thioridazine. Do not use paroxetine within 14 days before or 14 days after you have used an MAO inhibitor, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine. Some young people have thoughts about suicide when first taking an antidepressant. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor Seek medical attention right away if you have symptoms such as: agitation, hallucinations, muscle stiffness, twitching, loss of coordination, dizziness, warmth or tingly feeling, nausea, vomiting, diarrhea, fever, sweating, tremors, racing heartbeats, or a seizure (convulsions). Do not stop using paroxetine without first asking your doctor. Before taking this medicine You should not use this medicine if you are allergic to paroxetine, or if you are also taking pimozide or thioridazine. Do not use an MAO inhibitor within 14 days before or 14 days after you take paroxetine. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine. After you stop taking paroxetine you must wait at least 14 days before you start taking an MAO inhibitor. To make sure paroxetine is safe for you, tell your doctor if you have: heart disease, high blood pressure, or a stroke; liver or kidney disease; a bleeding or blood clotting disorder; seizures or epilepsy; bipolar disorder (manic depression), drug addiction, or suicidal thoughts; sexual problems; narrow-angle glaucoma; or low levels of sodium in your blood. Be sure your doctor knows if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. These medicines may interact with paroxetine and cause a serious condition called serotonin syndrome. Some young people have thoughts about suicide when first taking an antidepressant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms. Taking an SSRI antidepressant during pregnancy may cause serious lung problems or other complications in the baby. However, you may have a relapse of depression if you stop taking your antidepressant. Tell your doctor right away if you become pregnant. Do not start or stop taking this medicine without your doctor's advice. Do not use Brisdelle if you are pregnant. You should not breastfeed while using this medicine. Paroxetine is not approved for use by anyone younger than 18 years old. How should I take paroxetine? Take paroxetine exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Swallow the extended-release tablet whole and do not crush, chew, or break it. Shake the oral suspension (liquid) before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon). It may take up to 4 weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve. Tell your doctor if you have any changes in sexual function, such as loss of interest in sex, trouble having an orgasm, or (in men) problems with erections or ejaculation. Some sexual problems can be treated. Do not stop using paroxetine suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using paroxetine. Follow your doctor's instructions about tapering your dose. Store at room temperature away from moisture, heat, and light.   What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of paroxetine can be fatal. What to avoid Avoid driving or hazardous activity until you know how paroxetine will affect you. Your reactions could be impaired. Ask your doctor before taking a nonsteroidal anti-inflammatory drug (NSAID) such as aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib (Celebrex), diclofenac, indomethacin, meloxicam, and others. Using an NSAID with paroxetine may cause you to bruise or bleed easily. Drinking alcohol with this medicine can cause side effects. Paroxetine side effects Get emergency medical help if you have signs of an allergic reaction to paroxetine (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling). Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself. Call your doctor at once if you have: racing thoughts, decreased need for sleep, unusual risk-taking behavior, feelings of extreme happiness or sadness, being more talkative than usual; blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights; unusual bone pain or tenderness, swelling or bruising; changes in weight or appetite; easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), coughing up blood; severe nervous system reaction - very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, fainting; or low levels of sodium in the body - headache, confusion, slurred speech, severe weakness, loss of coordination, feeling unsteady. Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea. Common paroxetine side effects may include: vision changes; weakness, drowsiness, dizziness, tiredness; sweating, anxiety, shaking; sleep problems (insomnia); loss of appetite, nausea, vomiting, diarrhea, constipation; dry mouth, yawning; infection; headache; or decreased sex drive, impotence, abnormal ejaculation, or difficulty having an orgasm. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect paroxetine? Using paroxetine with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures. Tell your doctor about all your other medicines, especially: cimetidine (Tagamet), digoxin, St. John's wort, tamoxifen, theophylline, tryptophan (sometimes called L-tryptophan), warfarin (Coumadin, Jantoven); a diuretic or "water pill"; heart rhythm medicine; HIV or AIDS medications; certain medicines to treat narcolepsy or ADHD - amphetamine, atomoxetine, dextroamphetamine, Adderall, Dexedrine, Evekeo, Vyvanse, and others; narcotic pain medicine - fentanyl, tramadol; medicine to treat anxiety, mood disorders, thought disorders, or mental illness - such as buspirone, lithium, other antidepressants, or antipsychotics; migraine headache medicine - sumatriptan, rizatriptan, zolmitriptan, and others; or seizure medicine - phenobarbital, phenytoin. This list is not complete. Other drugs may interact with paroxetine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

What is pentoxifylline? Pentoxifylline causes changes in your blood that help improve blood flow. This also helps your blood carry oxygen to your tissues and organs. Pentoxifylline is used to improve blood flow and reduce certain symptoms of a condition called intermittent claudication (IN-ter-MIT-ent KLOD-ih-KAY-tion). Pentoxifylline is not a cure for this condition. Pentoxifylline may also be used for purposes not listed in this medication guide. Warnings You should not use pentoxifylline if you have recently had any type of bleeding in your brain or the retina of your eye. Before taking this medicine You should not use this medicine if you are allergic to pentoxifylline, or if you are allergic to caffeine or theophylline (Elixophyllin, Theo-24, Theo-Dur, Slo-Bid, Theochron, Theolair, Uniphyl, and others). You also should not use pentoxifylline if you have recently had any type of bleeding in your brain or the retina of your eyes. To make sure pentoxifylline is safe for you, tell your doctor if you have: coronary artery disease (hardened arteries); liver or kidney disease; heart disease; a history of bleeding in your brain or inside your eyes; history of heart attack or stroke; a stomach or intestinal ulcer; if you have recently had surgery; if you are also using theophylline; or if you use medicine to treat or prevent blod clots. It is not known whether pentoxifylline will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine. Pentoxifylline can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are using pentoxifylline. How should I take pentoxifylline? Follow all directions on your prescription label. Do not take pentoxifylline in larger or smaller amounts or for longer than recommended. Pentoxifylline is usually taken 3 times each day, with meals. Follow your doctor's instructions. While using pentoxifylline, you may need frequent blood tests. Do not crush, chew, or break an extended-release tablet. Swallow it whole. It may take up to 4 weeks before your symptoms improve. Keep using the medicine as directed and tell your doctor if your symptoms do not improve after 8 weeks of treatment. Store at room temperature away from moisture, heat, and light. What happens if I miss a dose? Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include severe drowsiness, agitation, fever, flushing (warmth, redness, or tingly feeling), fainting, or seizure. What should I avoid while taking pentoxifylline? Follow your doctor's instructions about any restrictions on food, beverages, or activity. Pentoxifylline side effects Stop taking pentoxifylline and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: chest pain; pounding heartbeats or fluttering in your chest; red or pink urine; a light-headed feeling, like you might pass out; or signs of stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds. Common side effects may include: dizziness, headache; nausea, vomiting; diarrhea, gas; or bloating, upset stomach. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Pentoxifylline dosing information Usual Adult Dose for Intermittent Claudication: 400 mg orally 3 times a day. If adverse effects develop, reducing the dose to 400 mg twice a day is recommended.   What other drugs will affect pentoxifylline? If you also take a blood thinner such as warfarin (Coumadin, Jantoven), you may need more frequent "INR" or prothrombin time tests to measure your blood-clotting time. Other drugs may interact with pentoxifylline, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

What is perphenazine? Perphenazine is a phenothiazine (FEEN-oh-THYE-a-zeen) anti-psychotic medicine. Perphenazine is used to treat psychotic disorders such as schizophrenia. It is also used to control severe nausea and vomiting. Perphenazine may also be used for purposes not listed in this medication guide. Warnings You should not use perphenazine if you have liver disease, brain damage, bone marrow depression, a blood cell disorder, or if you are also using large amounts of alcohol or medicines that make you sleepy. Perphenazine is not approved for use in older adults with dementia-related psychosis. Call your doctor at once if you have twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs. These could be early signs of dangerous side effects. Before taking this medicine You should not use perphenazine if you are allergic to any phenothiazine (such as perphenazine, chlorpromazine, prochlorperazine, promethazine, o thioridazine), or if you have: liver disease; brain damage; bone marrow depression; a blood cell disorder (such as low platelets or low red or white blood cell counts); or if you are also using large amounts of alcohol or medicines that make you sleepy. Perphenazine may increase the risk of death in older adults with dementia-related psychosis and is not approved for this use. Tell your doctor if you have ever had: severe or untreated depression; heart disease or high blood pressure; kidney disease; severe asthma, emphysema, or other breathing problem; seizures; Parkinson's disease; breast cancer; adrenal gland tumor (pheochromocytoma); enlarged prostate or urination problems; low levels of calcium in your blood (hypocalcemia); glaucoma; or a serious side effect while using perphenazine or another phenothiazine. Tell your doctor if you will be exposed to extreme heat or cold, or to insecticide poisons while you are taking perphenazine. Tell your doctor if you are pregnant or you become pregnant. Taking antipsychotic medicine in the last 3 months of pregnancy may cause breathing problems, feeding problems, or withdrawal symptoms in the newborn. It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk. How should I take perphenazine? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. You will need frequent medical tests. If you need surgery, tell your surgeon you currently use this medicine. Do not stop using perphenazine suddenly, or you could have unpleasant symptoms such as nausea, vomiting, dizziness, or tremors. Ask your doctor how to safely stop using this medicine. Store at room temperature away from moisture, heat, and light. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of perphenazine can be fatal. What should I avoid while taking perphenazine? Avoid driving or hazardous activity until you know how perphenazine will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Avoid drinking alcohol. It can increase some of the side effects of perphenazine. Avoid exposure to sunlight or tanning beds. Perphenazine can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors. Perphenazine side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. High doses or long-term use of perphenazine can cause a serious movement disorder that may not be reversible. The longer you use perphenazine, the more likely you are to develop this disorder, especially if you are a woman or an older adult. Call your doctor at once if you have: uncontrolled muscle movements in your arms or legs, or your face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement); worsening symptoms of schizophrenia; confusion, paranoia, feeling restless or excited; seizure (convulsions); a light-headed feeling, like you might pass out; jaundice (yellowing of your skin or eyes); little or no urinating; slow heart rate, weak pulse, weak or shallow breathing; low white blood cell counts--fever, chills, mouth sores, skin sores, sore throat, cough, trouble breathing, feeling light-headed; or severe nervous system reaction--very stiff (rigid) muscles, high fever, sweating, fast or uneven heartbeats. Side effects such as dry mouth, constipation, tremors, and drowsiness may be more likely in older adults. Common side effects may include: mild dizziness or drowsiness; blurred vision, headache; sleep problems (insomnia), strange dreams; loss of appetite, vomiting, diarrhea, constipation; increased sweating or urination; dry mouth or stuffy nose; breast swelling or discharge; or mild itching or skin rash. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Perphenazine dosing information Usual Adult Dose for Psychosis: Moderately disturbed, nonhospitalized patients: -Recommended dose: 4 to 8 mg orally 3 times a day, with a dose reduction to the minimum effective dose as soon as possible -Maximum dose: 24 mg/day Hospitalized patients: -Recommended dose: 8 to 16 mg orally 2 to 4 times a day -Maximum dose: 64 mg/day Comment: -Nonhospitalized patients should be limited to a daily dose of 24 mg; maximum doses of 64 mg should be used in hospitalized patients. Use: Treatment of schizophrenia Usual Adult Dose for Nausea/Vomiting: Recommended dose: 8 to 16 mg orally, in divided doses Maximum dose: 24 mg/day, in divided doses Comment: -The dose should be reduced as early as possible. Use: Severe nausea and vomiting Usual Pediatric Dose for Psychosis: 12 years and older: Moderately disturbed, nonhospitalized patients: -Recommended dose: 4 to 8 mg orally 3 times a day, with a dose reduction to the minimum effective dose as soon as possible -Maximum dose: 24 mg/day Hospitalized patients: -Recommended dose: 8 to 16 mg orally 2 to 4 times a day -Maximum dose: 64 mg/day Comments: -Nonhospitalized patients should be limited to a daily dose of 24 mg; maximum doses of 64 mg should be used in hospitalized patients. Use: Treatment of schizophrenia Usual Pediatric Dose for Nausea/Vomiting: 12 years and older: -Recommended dose: 8 to 16 mg orally, in divided doses -Maximum dose: 24 mg/day, in divided doses Comment: -The dose should be reduced as early as possible. Use: Severe nausea and vomiting   What other drugs will affect perphenazine? Taking perphenazine with other drugs that make you sleepy or slow your breathing can cause dangerous or life-threatening side effects. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures. Many drugs can affect perphenazine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

What is phenelzine? Phenelzine is a monoamine oxidase inhibitor (MAOI) that is used to treat symptoms of atypical depression in adults when other medicines have not been effective. Phenelzine is not for treating severe depression or bipolar disorder (manic depression). Phenelzine may also be used for purposes not listed in this medication guide. Warnings Some young people have thoughts about suicide when first taking an antidepressant. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor. There are many other drugs, foods, and beverages that can cause dangerously high blood pressure if you take them together with phenelzine. Tell your doctor about all your current medicines and any you start or stop using. Avoid drinking alcohol, and learn about the foods you should avoid. Symptoms of dangerously high blood pressure include: a sudden and severe headache, nausea, vomiting, fever, cold sweat, dilated pupils, light sensitivity, fast or pounding heartbeats, neck stiffness, weakness, or problems with vision or speech. Before taking this medicine You should not use phenelzine if you are allergic to it, or if you have: pheochromocytoma (tumor of the adrenal gland). congestive heart failure; severe kidney disease; or a history of liver problems or abnormal liver function tests. A dangerous drug interaction can occur between phenelzine and certain other medicines you use within 14 days before or after taking phenelzine. Your doctor may change your treatment plan if you need to use any of these medicines, including: epinephrine or norepinephrine; bupropion, buspirone, carbamazepine, guanethidine, levodopa, meperidine, methyldopa, tryptophan; ADHD medication; diet pills, cough and cold or allergy medicines; opioid medicine; other antidepressants; another MAO inhibitor--furazolidone, isocarboxazid, linezolid, methylene blue injection, procarbazine, rasagiline, selegiline, tranylcypromine, and others; or drugs that affect serotonin levels in your body--stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. This is not a complete list and there may be other medicines you should not take while you are taking phenelzine. Tell your doctor if you have ever had: high blood pressure, heart disease; diabetes; schizophrenia; epilepsy or other seizure disorder; or if you have taken another antidepressant within the past 5 weeks. Some young people have thoughts about suicide when first taking an antidepressant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms. Tell your doctor if you are pregnant or breastfeeding. Phenelzine is not approved for use by anyone younger than 18 years old. How should I take phenelzine? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Your blood pressure will need to be checked often. You may need to stop using phenelzine for a short time before any type of surgery or medical procedure. Tell any doctor who treats you that you take phenelzine. It may take a few weeks before you receive the full benefit of taking phenelzine. Your doctor will determine how long to treat you with phenelzine. Do not stop using phenelzine suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine. Store at room temperature away from moisture and heat. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include feeling drowsy or dizzy, severe headache, neck pain or stiffness, hallucinations, shallow breathing, fast and uneven heart rate, cold sweats, feeling like you might pass out, or seizure (convulsions). What should I avoid while taking phenelzine? Do not drink alcohol. Dangerous side effects could occur. You must not eat certain foods, including: air dried, aged, smoked, or fermented meats, including sausage, pepperoni, Lebanon bologna, or salami; beer, wine, reduced-alcohol or alcohol-free beer or wine; pickled herring; aged cheeses, including blue, boursault, brie, camembert, cheddar, gruyere, mozzarella, parmesan, Romano, Roquefort, and Swiss; moldy or improperly stored meat, fish, poultry, or liver; soy sauce, miso soup, bean curd, fava beans; sauerkraut; yogurt; yeast extracts, Marmite; or excessive amounts of chocolate or caffeine. Eating these foods while you are taking phenelzine can raise your blood pressure to dangerous levels, causing life-threatening side effects. Also avoid these foods for 2 weeks after you stop taking phenelzine. Phenelzine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Phenelzine side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself. Call your doctor at once if you have: sudden and severe headache, neck pain or stiffness; pounding heartbeats or fluttering in your chest; fast or slow heartbeats; chest pain; a light-headed feeling, like you might pass out; sweating (sometimes with fever and sometimes with cold, clammy skin); nausea, vomiting; or dilated pupils (your eyes may be more sensitive to light). Common side effects may include: dizziness, feeling light-headed; drowsiness, sleep problems; headache; feeling weak or tired; tremors, muscle twitching; dry mouth, stomach discomfort, constipation; swelling, weight gain; or sexual problems. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Phenelzine dosing information Usual Adult Dose for Depression: Early phase treatment: -Initial dose: 15 mg orally 3 times a day -Dose titration: Increase to at least 60 mg per day fairly rapidly, as tolerated -Maximum dose: 90 mg/day Maintenance: -Maintenance dose may be as low as 15 mg orally once a day or 15 mg orally every other day -Duration of therapy: As long as required Comments: -This drug should rarely be the first antidepressant used; it is more suitable for patients unresponsive to more commonly used medications. -This drug is effective in depressed patients characterized as atypical, nonendogenous, or neurotic, who often have mixed anxiety and depression and phobic or hypochondriacal features. -Evidence of usefulness in severely depressed patients with endogenous features is less conclusive. -Clinical response may not be seen until at least 4 weeks at 60 mg per day dosing -After maximal benefit is achieved, reduce dose slowly over several weeks. Use: Treatment of clinically characterized atypical, nonendogenous, or neurotic depression, especially in patients who have failed first-line treatments   What other drugs will affect phenelzine? When you start or stop taking phenelzine, your doctor may need to adjust the doses of any other medicines you take on a regular basis. There are many other drugs that can cause serious medical problems if you take them together with phenelzine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide. Tell your doctor about all your current medicines and any medicine you start or stop using.

What is phentermine? Phentermine is similar to an amphetamine. It stimulates the central nervous system (nerves and brain), which increases your heart rate and blood pressure and decreases your appetite. Phentermine is used together with diet and exercise to treat obesity, especially in people with risk factors such as high blood pressure, high cholesterol, or diabetes. Phentermine may also be used for purposes not listed in this medication guide. Warnings Do not use phentermine if you are pregnant or breast-feeding a baby. You should not use phentermine if you have glaucoma, overactive thyroid, severe heart problems, uncontrolled high blood pressure, advanced coronary artery disease, extreme agitation, or a history of drug abuse. Do not use this medicine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine. A dangerous drug interaction could occur. Before taking this medicine You should not use phentermine if you are allergic to it, or if you have: a history of heart disease (coronary artery disease, heart rhythm problems, congestive heart failure, stroke); severe or uncontrolled high blood pressure; overactive thyroid; glaucoma; extreme agitation or nervousness; a history of drug abuse; or if you take other diet pills. Do not use phentermine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others. Weight loss during pregnancy can harm an unborn baby, even if you are overweight. Do not use phentermine if you are pregnant. Tell your doctor right away if you become pregnant during treatment. You should not breast-feed while using this medicine. To make sure this medicine is safe for you, tell your doctor if you have: heart disease or coronary artery disease; a heart valve disorder; high blood pressure; diabetes (your diabetes medication dose may need to be adjusted); or kidney disease. Phentermine is not approved for use by anyone younger than 16 years old. How should I take phentermine? Take phentermine exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Doses are normally taken before breakfast, or 1 to 2 hours after breakfast. Follow your doctor's dosing instructions very carefully. Never use phentermine in larger amounts, or for longer than prescribed. Taking more of this medication will not make it more effective and can cause serious, life-threatening side effects. This medicine is for short-term use only. The effects of appetite suppression may wear off after a few weeks. Phentermine may be habit-forming. Misuse can cause addiction, overdose, or death. Selling or giving away this medicine is against the law. Call your doctor at once if you think this medicine is not working as well, or if you have not lost at least 4 pounds within 4 weeks. Do not stop using this medicine suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine. Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use. Dosing information Usual Adult Dose for Obesity: 8 mg orally 3 times a day 30 minutes before meals, OR 15 to 37.5 mg orally once a day before breakfast or 1 to 2 hours after breakfast. Use: Short-term (a few weeks) adjunct in a regimen of weight reduction based on exercise, behavioral modification, and caloric restriction in the management of exogenous obesity in patients with an initial body mass index (BMI) of 30 kg/m2 or greater, or BMI of 27 kg/m2 or greater in the presence of other risk factors (e.g., controlled hypertension, diabetes, hyperlipidemia). Usual Pediatric Dose for Obesity: Age 17 Years and Older: 8 mg orally 3 times a day 30 minutes before meals, OR 15 to 37.5 mg orally once a day before breakfast or 1 to 2 hours after breakfast. Use: Short-term (a few weeks) adjunct in a regimen of weight reduction based on exercise, behavioral modification, and caloric restriction in the management of exogenous obesity in patients with an initial body mass index (BMI) of 30 kg/m2 or greater, or BMI of 27 kg/m2 or greater in the presence of other risk factors (e.g., controlled hypertension, diabetes, hyperlipidemia).   What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is late in the day. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of phentermine can be fatal. Overdose symptoms may include confusion, panic, hallucinations, extreme restlessness, nausea, vomiting, diarrhea, stomach cramps, feeling tired or depressed, irregular heartbeats, weak pulse, seizure, or slow breathing (breathing may stop). What to avoid Avoid driving or hazardous activity until you know how phentermine will affect you. Your reactions could be impaired. Drinking alcohol with this medicine can cause side effects. Phentermine side effects Get emergency medical help if you have signs of an allergic reaction to phentermine: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: feeling short of breath, even with mild exertion; chest pain, feeling like you might pass out; swelling in your ankles or feet; pounding heartbeats or fluttering in your chest; tremors, feeling restless, trouble sleeping; unusual changes in mood or behavior; or increased blood pressure - severe headache, blurred vision, pounding in your neck or ears, anxiety, nosebleed. Common phentermine side effects may include: itching; dizziness, headache; dry mouth, unpleasant taste; diarrhea, constipation, stomach pain; or increased or decreased interest in sex. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect phentermine? Taking phentermine together with other diet medications such as fenfluramine (Phen-Fen) or dexfenfluramine (Redux) can cause a rare fatal lung disorder called pulmonary hypertension. Do not take phentermine with any other diet medications without your doctor's advice. Many drugs can interact with phentermine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

What is Phenytoin Sodium, Prompt? Phenytoin Sodium, Prompt injection is an anticonvulsant medication that is used to treat a prolonged seizure (status epilepticus). Phenytoin Sodium, Prompt injection is also used to prevent seizures during a surgery. Phenytoin Sodium, Prompt injection may also be used for purposes not listed in this medication guide. Warnings A Phenytoin Sodium, Prompt injection may cause life-threatening heart problems. Phenytoin Sodium, Prompt Sodium, Prompt is usually given by injection only if you are unable to take the medicine by mouth. If possible before you receive a Phenytoin Sodium, Prompt injection, tell your caregivers if you have ever had serious heart problems, or slow heartbeats that have caused you to faint. Your heart rate, breathing, blood pressure, and other vital signs will be watched closely. Tell your caregiver if you feel weak, light-headed, or short of breath during or after an injection. Before taking this medicine If possible before you receive a Phenytoin Sodium, Prompt injection, tell your caregivers if you have ever had: a heart condition called 2nd or 3rd degree "AV block"; slow heartbeats that have caused you to faint; liver problems caused by Phenytoin Sodium, Prompt Sodium, Prompt; or if you currently take delavirdine (Rescriptor). Tell your doctor if you have ever had: liver or kidney disease; diabetes; porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system); or if you are of Asian ancestry (you may need a special blood test to determine your risk for having a skin reaction to Phenytoin Sodium, Prompt Sodium, Prompt). Tell your doctor if you are pregnant. Phenytoin Sodium, Prompt may cause harm to an unborn baby, but having a seizure during pregnancy could harm both mother and baby. The benefit of preventing seizures may outweigh any risks to the baby. If you have received a Phenytoin Sodium, Prompt injection during pregnancy, be sure to tell the doctor who delivers your baby about your Phenytoin Sodium, Prompt use. Both you and the baby may need to receive medications to prevent excessive bleeding during delivery and just after birth. If you are pregnant, your name may be listed on a pregnancy registry to track the effects of Phenytoin Sodium, Prompt on the baby. Phenytoin Sodium, Prompt can make birth control pills less effective. Ask your doctor about using a non-hormonal birth control (condom, diaphragm with spermicide) to prevent pregnancy. It may not be safe to breast-feed while using this medicine. Ask your doctor about any risk. In an emergency, you may not be able to tell caregivers if you are pregnant or breast feeding. Make sure any doctor caring for your pregnancy or your baby knows you received this medicine. How is Phenytoin Sodium, Prompt given? Phenytoin Sodium, Prompt is injected into a muscle, or given as an infusion into a vein. A healthcare provider will give you this injection if you are unable to take the medicine by mouth. Your breathing, blood pressure, oxygen levels, and other vital signs will be watched closely. Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when Phenytoin Sodium, Prompt is injected. While receiving Phenytoin Sodium, Prompt, you may need frequent blood tests. You may also need a blood test when switching from the injection form to the oral form of Phenytoin Sodium, Prompt. You should not stop using Phenytoin Sodium, Prompt suddenly, even if you feel fine. Stopping suddenly may cause increased seizures. Follow your doctor's instructions about tapering your dose. Phenytoin Sodium, Prompt can cause swelling in your gums. Pay special attention to your dental hygiene while receiving Phenytoin Sodium, Prompt Sodium, Prompt. Brush and floss your teeth regularly. What happens if I miss a dose? Because you will receive Phenytoin Sodium, Prompt Sodium, Prompts in a clinical setting, you are not likely to miss a dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of Phenytoin Sodium, Prompt can be fatal. Overdose symptoms may include twitching eye movements, slurred speech, loss of balance, tremor, muscle stiffness or weakness, nausea, vomiting, feeling light-headed, fainting, and slow or shallow breathing. What should I avoid while taking Phenytoin Sodium, Prompt? Avoid driving or hazardous activity until you know how Phenytoin Sodium, Prompt Sodium, Prompt will affect you. Your reactions could be impaired. Avoid drinking alcohol while you are taking Phenytoin Sodium, Prompt. Alcohol use can increase your blood levels of Phenytoin Sodium, Prompt and may increase side effects. Daily alcohol use can decrease your blood levels of Phenytoin Sodium, Prompt, which can increase your risk of seizures. Ask a doctor or pharmacist before using over-the-counter medicines such as cimetidine, omeprazole, St. John's wort, or vitamins and mineral supplements that contain folic acid. Phenytoin Sodium, Prompt side effects Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling). Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes. A Phenytoin Sodium, Prompt injection may cause life-threatening heart problems. Tell your caregiver if you feel weak, light-headed, or short of breath during or after an injection. Call your doctor at once if you have: a light-headed feeling, like you might pass out; confusion, unusual thoughts or behavior; fever, chills, sore throat, swollen glands; red or swollen gums, mouth sores; easy bruising, unusual bleeding; pain, swelling, bruising, or other irritation where the injection was given; purple discoloration of your skin around the IV needle, or spreading away from where the medicine was injected (may occur several days after an injection); increased thirst, increased urination; or liver problems--loss of appetite, upper stomach pain, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes). Common side effects may include: drowsiness, confusion; slurred speech; abnormal eye movement; or problems with balance or muscle movement. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   What other drugs will affect Phenytoin Sodium, Prompt? Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective. Many drugs can interact with Phenytoin Sodium, Prompt. Not all possible interactions are listed here. TELL YOUR DOCTOR ABOUT ALL OTHER MEDICINES YOU USE, and any you start or stop using during treatment with Phenytoin Sodium, Prompt. This includes prescription and over-the-counter medicines, vitamins, and herbal products.

What is pioglitazone? Pioglitazone is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. Pioglitazone is not for treating type 1 diabetes. Pioglitazone may also be used for purposes not listed in this medication guide. Warnings Pioglitazone can cause or worsen congestive heart failure. You should not use pioglitazone if you have severe or uncontrolled heart failure. Stop using this medicine and call your doctor at once if you have shortness of breath (especially when lying down), unusual tiredness, swelling, or rapid weight gain. Before taking this medicine You should not use this medicine if you are allergic to pioglitazone, or if you have: severe or uncontrolled heart failure; or diabetic ketoacidosis (call your doctor for treatment). This medication may increase your risk of developing bladder cancer. Talk with your doctor about your specific risk. Tell your doctor if you have ever had: congestive heart failure or heart disease; a heart attack or stroke; eye problems caused by diabetes; bladder cancer; or liver disease. Pioglitazone may increase your risk of serious heart problems, but not treating your diabetes can also damage your heart and other organs. Talk to your doctor about the risks and benefits of this medicine. Follow your doctor's instructions about using this medicine if you are pregnant or you become pregnant. Controlling diabetes is very important during pregnancy, and having high blood sugar may cause complications in both the mother and the baby. Pioglitazone may stimulate ovulation in a premenopausal woman and may increase the risk of unintended pregnancy. Talk to your doctor about your risk. Women may be more likely to have a broken bone while using pioglitazone. Talk with your doctor about ways to keep your bones healthy. It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk. Pioglitazone is not approved for use by anyone younger than 18 years old. How should I take pioglitazone? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Pioglitazone is usually taken once daily, with or without food. You may have low blood sugar (hypoglycemia) and feel very hungry, dizzy, irritable, confused, anxious, or shaky. To quickly treat hypoglycemia, eat or drink a fast-acting source of sugar (fruit juice, hard candy, crackers, raisins, or non-diet soda). Your doctor may prescribe a glucagon injection kit in case you have severe hypoglycemia. Be sure your family or close friends know how to give you this injection in an emergency. Blood sugar levels can be affected by stress, illness, surgery, exercise, alcohol use, or skipping meals. Ask your doctor before changing your dose or medication schedule. Pioglitazone is only part of a treatment program that may also include diet, exercise, weight control, blood sugar testing, and special medical care. Follow your doctor's instructions very closely. Store at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use. What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. You may have signs of low blood sugar, such as extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, and seizure (convulsions). What should I avoid while taking pioglitazone? Avoid drinking alcohol. It lowers blood sugar and may interfere with your diabetes treatment. Pioglitazone side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using pioglitazone and call your doctor at once if you have symptoms of liver damage: nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes). Call your doctor at once if you have: shortness of breath (especially when lying down), unusual tiredness, swelling, rapid weight gain; pink or red urine, painful or difficult urination, new or worsening urge to urinate; changes in your vision; or sudden unusual pain in your hand, arm, or foot. Some people taking pioglitazone have had bladder cancer, but it is not clear if pioglitazone was the actual cause. Common side effects may include: headache; muscle pain; or cold symptoms such as stuffy nose, sinus pain, sneezing, sore throat. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.   Pioglitazone dosing information Usual Adult Dose for Diabetes Type 2: -Patients without congestive heart failure: Initial dose: 15 mg or 30 mg orally once a day -Patients with congestive heart failure (New York Heart Association [NYHA] Class I or II): Initial dose: 15 mg orally once a day Maintenance dose: 15 mg to 45 mg orally once a day based on glycemic response as determined by HbA1c Maximum dose: 45 mg orally once a day Comments: -This drug exerts its antihyperglycemic effect only in the presence of endogenous insulin and therefore is not expected to be effective in patients with type 1 diabetes mellitus or diabetic ketoacidosis. -Patients concomitantly receiving an insulin secretagogue or insulin may need to reduce the dose of the insulin secretagogue or insulin if hypoglycemia occurs. Use: As an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus in multiple clinical settings   What other drugs will affect pioglitazone? Tell your doctor if you use insulin. Taking pioglitazone while you are using insulin may increase your risk of serious heart problems. Many drugs can affect pioglitazone. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.