ALKALINE PHOSPHATASE

"Clinical Significance
Alkaline Phosphatase - Serum alkaline phosphatase levels are of interest in the diagnosis of hepatobiliary disorders and bone disease associated with increased osteoblastic activity. Moderate elevations of alkaline phosphatase may be seen in several conditions that do not involve the liver or bone. Among these are Hodgkin's disease, congestive heart failure, ulcerative colitis, regional enteritis, and intra-abdominal bacterial infections. Elevations are also observed during the third trimester of pregnancy.

Preferred Specimen(s)
1 mL serum

Alternative Specimen(s)
Sodium heparin (green-top) tube • Lithium heparin (green-top) tube

Transport Container
Serum Separator Tube (SST®)

Transport Temperature
Room temperature

Specimen Stability
Serum and plasma
Room temperature: 7 days
Refrigerated: 7 days
Frozen: 28 days

Reject Criteria
Anticoagulants other than heparin

Setup Schedule, Minimum Volume"

Methodology
Spectrophotometry (SP)

Reference Range(s)
 Male (U/L)    Female (U/L)
0-6 Days    46-245    46-245
7-14 Days    69-306    69-306
15 Days-<1 Month    113-412    113-412
1-5 Months    104-450    104-450
6-11 Months    100-334    100-334
1-9 Years    117-311    117-311
10 Years    128-396    128-396
11 Years    125-428    100-429
12 Years    123-426    69-296
13 Years    100-417    58-258
14 Years    78-326    51-179
15 Years    65-278    45-150
16 Years    56-234    41-140
17-19 Years    46-169    36-128
20-49 Years    36-130    31-125
>49 Years    35-144    37-153